TDR Targets

Basic information

Technical information

TDR Targets ID: 876178
Name: 3-butyl-6-ethylthieno[3,2-e]pyrimidin-4-one
MW: 236.333 | Formula: C12H16N2OS
H donors: 0 H acceptors: 1 LogP: 2.99 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCCn1cnc2c(c1=O)cc(s2)CC
InChi: 1S/C12H16N2OS/c1-3-5-6-14-8-13-11-10(12(14)15)7-9(4-2)16-11/h7-8H,3-6H2,1-2H3
InChiKey: PHNRMTGQHJQPIN-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-butyl-6-ethyl-thieno[3,2-e]pyrimidin-4-one
3-butyl-6-ethyl-4-thieno[3,2-e]pyrimidinone
ZINC01892806

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0407	0.147
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0143	0.0515
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.1276	1	0.5
Echinococcus granulosus	expressed conserved protein	0.0112	0.0688	0.225
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.2079	0.2726
Plasmodium falciparum	importin beta, putative	0.0035	0.0074	0.0074
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0119	0.0746	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0124	0.0449
Schistosoma mansoni	hypothetical protein	0.0058	0.0261	0.0942
Brugia malayi	CHE-14 protein	0.0051	0.0203	0.0977
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0021	0.0057
Brugia malayi	RNA, U transporter 1	0.0099	0.0587	0.2823
Echinococcus multilocularis	sterol regulatory element binding protein	0.0051	0.0203	0.0266
Schistosoma mansoni	hypothetical protein	0.0041	0.0124	0.0449
Treponema pallidum	polypeptide deformylase (def)	0.1276	1	0.5
Echinococcus multilocularis	expressed conserved protein	0.0112	0.0688	0.0902
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0074	0.0074
Brugia malayi	TAR-binding protein	0.0076	0.0407	0.1957
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0121	0.0761	0.2748
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0487	0.3689	1
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0407	0.0533
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0021	0.0057
Trypanosoma brucei	Peptide deformylase 2	0.0487	0.3689	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.7628	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0188	0.0681
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0261	0.0942
Mycobacterium ulcerans	peptide deformylase	0.1276	1	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0277	0.133
Toxoplasma gondii	hypothetical protein	0.1276	1	1
Plasmodium falciparum	peptide deformylase	0.1276	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0273	0.0985
Echinococcus granulosus	sterol regulatory element binding protein	0.0051	0.0203	0.0664
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0407	0.147
Echinococcus granulosus	Niemann Pick C1 protein	0.0119	0.0746	0.2439
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0143	0.0187
Onchocerca volvulus		0.006	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0074	0.0266
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0021	0.1027
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.2079	0.6797
Plasmodium vivax	peptide deformylase, putative	0.1276	1	1
Echinococcus granulosus	tumor protein p63	0.0408	0.3059	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0295	0.1065
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0021	0.1027
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0074	0.0096
Echinococcus multilocularis	tumor protein p63	0.0408	0.3059	0.401
Brugia malayi	hypothetical protein	0.0043	0.0143	0.0686
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0026	0	0.5
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0487	0.3689	1
Echinococcus granulosus	Niemann Pick C1 protein	0.017	0.1154	0.3773
Entamoeba histolytica	hypothetical protein	0.0043	0.0143	0.1911
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0407	0.147
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0407	0.147
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0074	0.0074
Schistosoma mansoni	hypothetical protein	0.0049	0.0188	0.0681
Echinococcus granulosus	snurportin 1	0.0372	0.2768	0.905
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.2768	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0143	0.0466
Schistosoma mansoni	hypothetical protein	0.0372	0.2768	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.017	0.1154	0.1513
Brugia malayi	RNA binding protein	0.0076	0.0407	0.1957
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0407	0.1957
Loa Loa (eye worm)	hypothetical protein	0.006	0.0277	0.0999
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0124	0.0597
Echinococcus multilocularis	protein patched	0.0051	0.0203	0.0266
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0407	0.147
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.1276	1	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0277	0.133
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0407	0.147
Echinococcus multilocularis	snurportin 1	0.0372	0.2768	0.3629
Leishmania major	polypeptide deformylase-like protein, putative	0.0487	0.3689	1
Echinococcus granulosus	Protein patched homolog 1	0.0051	0.0203	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0286	0.2079	0.751
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0407	0.147
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0051	0.0203	0.0734
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0273	0.0985
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0407	0.147
Schistosoma mansoni	importin beta-1	0.0035	0.0074	0.0266
Echinococcus multilocularis	protein dispatched 1	0.0058	0.0261	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0203	0.0734
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0487	0.3689	1
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0203	1
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.1276	1	0.5
Entamoeba histolytica	hypothetical protein	0.0043	0.0143	0.1911
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0261	0.1255
Echinococcus multilocularis	Niemann Pick C1 protein	0.0119	0.0746	0.0978
Brugia malayi	Importin beta-1 subunit	0.0035	0.0074	0.0354
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0487	0.3689	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0074	0.0199
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0021	0.1027
Entamoeba histolytica	hypothetical protein	0.0043	0.0143	0.1911
Entamoeba histolytica	hypothetical protein	0.0028	0.0021	0.028
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0074	0.024
Trypanosoma brucei	Polypeptide deformylase 1	0.0487	0.3689	1
Brugia malayi	hypothetical protein	0.0286	0.2079	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0143	0.0515
Schistosoma mansoni	patched 1	0.0051	0.0203	0.0734
Brugia malayi	Niemann-Pick C1 protein precursor	0.0119	0.0746	0.3588
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0277	0.0999
Schistosoma mansoni	hypothetical protein	0.0049	0.0188	0.0681
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0074	0.0199
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0407	0.133
Schistosoma mansoni	hypothetical protein	0.0049	0.0188	0.0681
Entamoeba histolytica	hypothetical protein	0.0043	0.0143	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0746	0.2695

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 876178