TDR Targets

Basic information

Technical information

TDR Targets ID: 876244
Name: 3-(3-diethylaminopropyl)-2-(5-methylthiophen- 2-yl)-1,3-thiazolidin-4-one
MW: 312.494 | Formula: C15H24N2OS2
H donors: 0 H acceptors: 1 LogP: 3.05 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCCN1C(=O)CSC1c1ccc(s1)C)CC
InChi: 1S/C15H24N2OS2/c1-4-16(5-2)9-6-10-17-14(18)11-19-15(17)13-8-7-12(3)20-13/h7-8,15H,4-6,9-11H2,1-3H3
InChiKey: CENPARPLCQRLIR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(3-diethylaminopropyl)-2-(5-methyl-2-thienyl)thiazolidin-4-one
3-(3-diethylaminopropyl)-2-(5-methyl-2-thienyl)-4-thiazolidinone
Oprea1_632473

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0128	0.0724	0.0724
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0147	0.0923	0.3504
Onchocerca volvulus		0.0161	0.1065	0.1814
Echinococcus multilocularis	tissue type plasminogen activator	0.0089	0.0318	0.1158
Schistosoma mansoni	nAChR subunit	0.0147	0.0923	0.3504
Brugia malayi	Kringle domain containing protein	0.0089	0.0318	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0773	0.0773
Loa Loa (eye worm)	ACC-1 protein	0.0308	0.2598	0.2598
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0308	0.2598	0.2565
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0308	0.2598	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0308	0.2598	1
Mycobacterium leprae	cell division protein FtsZ	0.0319	0.2722	0.5
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0308	0.2598	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0161	0.1065	0.4056
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1065	0.1065
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0063	0.0044	0.0095
Onchocerca volvulus	Putative nachr subunit	0.0308	0.2598	0.5533
Echinococcus granulosus	biogenic amine 5HT receptor	0.0133	0.0773	0.2922
Onchocerca volvulus		0.0308	0.2598	0.5533
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0319	0.2722	1
Schistosoma mansoni	nAChR subunit	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1065	0.1065
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0308	0.2598	0.2565
Loa Loa (eye worm)	acetylcholine receptor protein	0.0147	0.0923	0.0923
Onchocerca volvulus		0.0308	0.2598	0.5533
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Toxoplasma gondii	kringle domain-containing protein	0.0089	0.0318	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0133	0.0773	0.2922
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0319	0.2722	0.5
Brugia malayi	Cell division protein ftsZ	0.0158	0.1034	0.0995
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0308	0.2598	1
Mycobacterium ulcerans	cell division protein FtsZ	0.0319	0.2722	1
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0147	0.0923	0.3504
Entamoeba histolytica	hypothetical protein	0.0161	0.1065	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0147	0.0923	0.0883
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0161	0.1065	0.1026
Loa Loa (eye worm)	runx1	0.0061	0.0023	0.0023
Leishmania major	hypothetical protein, conserved	0.0089	0.0318	1
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Loa Loa (eye worm)	LGC-31 protein	0.0308	0.2598	0.2598
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0147	0.0923	0.0923
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0308	0.2598	0.2565
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0308	0.2598	1
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0147	0.0923	0.0883
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0147	0.0923	0.0883
Schistosoma mansoni	nAChR subunit	0.0147	0.0923	0.3504
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1065	0.1065
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1065	0.1065
Onchocerca volvulus		0.0147	0.0923	0.1468
Echinococcus granulosus	tissue type plasminogen activator	0.0089	0.0318	0.1158
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0308	0.2598	0.2565
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Onchocerca volvulus		0.0308	0.2598	0.5533
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0308	0.2598	0.2565
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0147	0.0923	0.3504
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Schistosoma mansoni	acetylcholine receptor-related	0.0147	0.0923	0.3504
Brugia malayi	Receptor family ligand binding region containing protein	0.0128	0.0724	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Schistosoma mansoni	nAChR subunit	0.0308	0.2598	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0484	0.4438	0.4438
Echinococcus multilocularis	nAChR subunit	0.0308	0.2598	1
Schistosoma mansoni	lozenge	0.0061	0.0023	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Brugia malayi	Cation transporter family protein	0.0308	0.2598	0.2565
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0308	0.2598	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0147	0.0923	0.3504
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1065	0.1065
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0773	0.0773
Onchocerca volvulus		0.0308	0.2598	0.5533
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Schistosoma mansoni	neurotransmitter gated ion channel	0.0147	0.0923	0.3504
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0161	0.1065	0.1026
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0318	0.0318
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Echinococcus granulosus	glycine receptor subunit beta	0.0308	0.2598	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0147	0.0923	0.3504
Loa Loa (eye worm)	ACC-1 protein	0.0308	0.2598	0.2598
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0161	0.1065	0.1026
Echinococcus multilocularis	serotonin receptor	0.0133	0.0773	0.2922
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0147	0.0923	0.0883
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0308	0.2598	1
Schistosoma mansoni	nAChR subunit	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Trypanosoma cruzi	hypothetical protein, conserved	0.0089	0.0318	0.5
Schistosoma mansoni	nAChR subunit	0.0308	0.2598	1
Onchocerca volvulus		0.0308	0.2598	0.5533
Echinococcus multilocularis	glycine receptor subunit beta	0.0308	0.2598	1
Brugia malayi	Cell division protein ftsZ	0.0153	0.0989	0.0949
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0147	0.0923	0.0923
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0161	0.1065	0.1026
Schistosoma mansoni	nAChR subunit	0.0308	0.2598	1
Echinococcus multilocularis	serotonin receptor	0.0133	0.0773	0.2922
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0308	0.2598	0.2565
Echinococcus multilocularis	nAChR subunit	0.0161	0.1065	0.4056
Schistosoma mansoni	nAChR subunit	0.0308	0.2598	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0089	0.0318	0.0318
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0063	0.0044	0.0095
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0308	0.2598	0.2565
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0308	0.2598	0.2565
Brugia malayi	hypothetical protein	0.0147	0.0923	0.0883
Onchocerca volvulus		0.0161	0.1065	0.1814
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0308	0.2598	1
Onchocerca volvulus		0.0308	0.2598	0.5533
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1065	0.1065
Brugia malayi	hypothetical protein	0.0147	0.0923	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Brugia malayi	hypothetical protein	0.0133	0.0777	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1065	0.1065
Onchocerca volvulus		0.0147	0.0923	0.1468
Brugia malayi	hypothetical protein	0.0484	0.4438	0.4414
Brugia malayi	Cation transporter family protein	0.0308	0.2598	0.2565
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0308	0.2598	0.2598
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0308	0.2598	0.2598
Schistosoma mansoni	neurotransmitter gated ion channel	0.0161	0.1065	0.4056
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0308	0.2598	0.2565
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0308	0.2598	0.2598
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0308	0.2598	0.2565
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0308	0.2598	1
Brugia malayi	hypothetical protein	0.0147	0.0923	0.0883
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0308	0.2598	0.2565
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0308	0.2598	0.2565
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0147	0.0923	0.0883
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0308	0.2598	1
Echinococcus granulosus	nAChR subunit	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Loa Loa (eye worm)	hypothetical protein	0.1017	1	1
Brugia malayi	hypothetical protein	0.0147	0.0923	0.0883
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0147	0.0923	0.3504
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0308	0.2598	0.2565
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0308	0.2598	0.2598
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0308	0.2598	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.0308	0.2598	0.2565
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0147	0.0923	0.0883
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Treponema pallidum	cell division protein FtsZ	0.0319	0.2722	0.5
Schistosoma mansoni	nAChR subunit	0.0308	0.2598	1
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0308	0.2598	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0063	0.0044	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0308	0.2598	0.2598
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0308	0.2598	1
Schistosoma mansoni	hypothetical protein	0.0089	0.0318	0.1158
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0161	0.1065	0.4056
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1065	0.1065
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0318	0.0275
Echinococcus multilocularis	Protein lozenge	0.0061	0.0023	0.0016
Echinococcus granulosus	nAChR subunit	0.0161	0.1065	0.4056
Brugia malayi	hypothetical protein	0.0147	0.0923	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0978	0.9589	0.9589
Onchocerca volvulus		0.0484	0.4438	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0308	0.2598	0.2598
Plasmodium vivax	tryptophan-rich antigen (Pv-fam-a)	0.0591	0.5551	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923
Loa Loa (eye worm)	GABA receptor subunit	0.0161	0.1065	0.1065
Onchocerca volvulus		0.0147	0.0923	0.1468
Loa Loa (eye worm)	hypothetical protein	0.0347	0.3006	0.3006
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0308	0.2598	0.2565
Plasmodium falciparum	cysteine repeat modular protein 1	0.0089	0.0318	0.5
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Echinococcus multilocularis	glycine receptor subunit beta	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0484	0.4438	0.4438
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0308	0.2598	0.2565
Echinococcus granulosus	glycine receptor subunit beta	0.0308	0.2598	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0308	0.2598	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.087	0.8467	0.8467
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Loa Loa (eye worm)	hypothetical protein	0.0308	0.2598	0.2598
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0147	0.0923	0.3504
Brugia malayi	Cation transporter family protein	0.0308	0.2598	0.2565
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0308	0.2598	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0923	0.0923

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 876244