Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0096 | 0.0186 | 0.0595 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0214 | 0.2032 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0457 | 0.5821 | 0.5821 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0457 | 0.5831 | 0.5831 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0164 | 0.1242 | 0.213 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.312 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0164 | 0.1242 | 0.3981 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0096 | 0.0186 | 0.0595 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0457 | 0.5831 | 0.5831 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0164 | 0.1242 | 0.213 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0096 | 0.0186 | 0.0318 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0284 | 0.312 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0457 | 0.5831 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0096 | 0.0186 | 0.0595 |
Trypanosoma brucei | oligopeptidase b | 0.0214 | 0.2032 | 0.3485 |
Echinococcus granulosus | prolyl endopeptidase | 0.0457 | 0.5831 | 0.5831 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.0096 | 0.0186 | 0.0318 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0271 | 0.2925 | 0.5016 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0096 | 0.0186 | 0.0186 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0164 | 0.1242 | 0.1242 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0271 | 0.2925 | 0.2925 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0457 | 0.5831 | 0.5831 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0271 | 0.2925 | 0.2925 |
Toxoplasma gondii | prolyl endopeptidase | 0.0457 | 0.5831 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0271 | 0.2925 | 0.2925 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0096 | 0.0186 | 0.0595 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0271 | 0.2925 | 0.5016 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0214 | 0.2032 | 0.3485 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0457 | 0.5821 | 0.9983 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0724 | 1 | 1 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0457 | 0.5831 | 0.5831 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.5831 | 0.5831 |
Echinococcus granulosus | cathepsin b | 0.0457 | 0.5821 | 0.5821 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.312 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.312 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0186 | 0.0186 |
Mycobacterium tuberculosis | Probable peptidase | 0.0214 | 0.2032 | 0.3405 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0214 | 0.2032 | 0.3485 |
Toxoplasma gondii | cathepsin B | 0.0164 | 0.1242 | 0.213 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0271 | 0.2925 | 0.2925 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.312 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0457 | 0.5821 | 0.5821 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0096 | 0.0186 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.1418 | 0.1418 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0096 | 0.0186 | 0.0186 |
Trypanosoma cruzi | oligopeptidase b | 0.0214 | 0.2032 | 0.3485 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.2174 | 0.3814 |
Plasmodium falciparum | peptidase, putative | 0.0096 | 0.0186 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0164 | 0.1242 | 0.3601 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0457 | 0.5821 | 0.5821 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0214 | 0.2032 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0096 | 0.0186 | 0.0318 |
Giardia lamblia | Cathepsin B precursor | 0.0164 | 0.1242 | 0.3601 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.312 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0096 | 0.0186 | 0.0318 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0457 | 0.5831 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0724 | 1 | 1 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0214 | 0.2032 | 0.3485 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0186 | 0.0186 |
Echinococcus multilocularis | cathepsin b | 0.0457 | 0.5821 | 0.5821 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0214 | 0.2032 | 0.3405 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0724 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.312 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0164 | 0.1242 | 0.3601 |
Echinococcus multilocularis | cathepsin b | 0.0457 | 0.5821 | 0.5821 |
Trypanosoma cruzi | oligopeptidase b | 0.0214 | 0.2032 | 0.3485 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0271 | 0.2925 | 0.5016 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0186 | 0.0595 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0271 | 0.2925 | 0.5016 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0457 | 0.5821 | 0.5821 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0096 | 0.0186 | 0.0595 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0096 | 0.0186 | 0.0595 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0271 | 0.2925 | 0.5016 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0284 | 0.312 | 1 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0096 | 0.0186 | 0.0186 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0096 | 0.0186 | 0.0595 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0724 | 1 | 1 |
Leishmania major | oligopeptidase b | 0.0214 | 0.2032 | 0.3485 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0284 | 0.312 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0284 | 0.312 | 0.5 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0164 | 0.1242 | 0.213 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0361 | 0.4325 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0724 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.5821 | 0.5821 |
Loa Loa (eye worm) | cathepsin B | 0.0164 | 0.1242 | 0.1242 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0096 | 0.0186 | 0.0186 |
Brugia malayi | hypothetical protein | 0.0175 | 0.1418 | 0.1418 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0457 | 0.5821 | 0.5821 |
Trypanosoma brucei | prolyl endopeptidase | 0.0457 | 0.5831 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0096 | 0.0186 | 0.0595 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0096 | 0.0186 | 0.0318 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0271 | 0.2925 | 0.5016 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0214 | 0.2032 | 0.3485 |
Plasmodium vivax | hypothetical protein, conserved | 0.0096 | 0.0186 | 1 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0214 | 0.2032 | 0.3485 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.312 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0457 | 0.5831 | 0.5831 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0096 | 0.0186 | 0.0186 |
Echinococcus granulosus | cathepsin b | 0.0457 | 0.5821 | 0.5821 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.312 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0096 | 0.0186 | 0.0186 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.