Detailed information for compound 877043

Basic information

Technical information
  • TDR Targets ID: 877043
  • Name: 6-morpholin-4-ylpyridin-3-amine
  • MW: 179.219 | Formula: C9H13N3O
  • H donors: 1 H acceptors: 1 LogP: 0.25 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(nc1)N1CCOCC1
  • InChi: 1S/C9H13N3O/c10-8-1-2-9(11-7-8)12-3-5-13-6-4-12/h1-2,7H,3-6,10H2
  • InChiKey: VVTSPTCBHTWXMD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-morpholinopyridin-3-amine
  • 6-morpholino-3-pyridinamine
  • (6-morpholino-3-pyridyl)amine
  • Oprea1_199946
  • SBB016386
  • 6-(Morpholino)pyridin-3-amine
  • EINECS 257-613-3
  • 4-(5-Amino-2-pyridyl)morpholine
  • AIDS-020469
  • AIDS020469

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.711 0.7093
Echinococcus granulosus carboxylesterase 5A 0.0071 0.1856 0.1856
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0182 0.0127
Schistosoma mansoni hypothetical protein 0.0308 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.4631 0.4601
Brugia malayi peptidase family M13 containing protein 0.0024 0.0255 0.0359
Loa Loa (eye worm) inositol-1 0.0037 0.0701 0.0648
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.1077 0.1027
Loa Loa (eye worm) hypothetical protein 0.0152 0.4631 0.4601
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0701 0.0701
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0568 0.1584
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0235 0.22
Mycobacterium tuberculosis Probable reductase 0.0109 0.3167 0.8837
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.107 0.107
Brugia malayi RNA, U transporter 1 0.0082 0.2248 0.3161
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2534 0.2534
Brugia malayi follicle stimulating hormone receptor 0.0224 0.711 1
Echinococcus multilocularis acetylcholinesterase 0.0071 0.1856 0.1856
Plasmodium falciparum glutathione reductase 0.0048 0.107 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0 0.5
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.107 1
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0098 0.2809 0.3951
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0056 0.0524
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0024 0.0255 0.0255
Echinococcus multilocularis carboxylesterase 5A 0.0071 0.1856 0.1856
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2534 0.2534
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.1077 0.1077
Mycobacterium leprae probable zinc metalloprotease 0.0098 0.2809 0.7432
Echinococcus granulosus endothelin converting enzyme 1 0.0098 0.2809 0.2809
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.3167 0.8837
Echinococcus granulosus GPCR family 2 0.0048 0.1077 0.1077
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0255 0.0255
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0685 0.0685
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.107 0.2985
Loa Loa (eye worm) hypothetical protein 0.0074 0.1987 0.1942
Loa Loa (eye worm) hypothetical protein 0.0098 0.2809 0.2769
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.3584 1
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0423 0.0423
Brugia malayi Cytochrome P450 family protein 0.0022 0.0182 0.0257
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.3167 0.8837
Brugia malayi Peptidase family M13 containing protein 0.0098 0.2809 0.3951
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0235 0.3359
Leishmania major importin beta-1 subunit, putative 0.0023 0.0235 0.22
Loa Loa (eye worm) hypothetical protein 0.0074 0.1987 0.1942
Brugia malayi Thioredoxin reductase 0.0048 0.107 0.1505
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0056 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0685 0.0685
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0701 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0056 0.0056
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.4631 0.6514
Schistosoma mansoni hypothetical protein 0.0036 0.0685 0.0685
Schistosoma mansoni importin beta-1 0.0029 0.0423 0.0423
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0056 0.08
Loa Loa (eye worm) hypothetical protein 0.0029 0.0423 0.0369
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0255 0.0255
Brugia malayi Carboxylesterase family protein 0.0071 0.1856 0.2611
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0701 0.655
Loa Loa (eye worm) peptidase family M13 containing protein 0.0073 0.1928 0.1883
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.1856 0.1856
Echinococcus multilocularis acetylcholinesterase 0.0071 0.1856 0.1856
Echinococcus granulosus acetylcholinesterase 0.0071 0.1856 0.1856
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.3167 0.8837
Loa Loa (eye worm) zinc metallopeptidase 4 0.0024 0.0255 0.02
Loa Loa (eye worm) hypothetical protein 0.0074 0.1987 0.1942
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0074 0.1987 0.1942
Schistosoma mansoni hypothetical protein 0.0104 0.2986 0.2986
Brugia malayi Carboxylesterase family protein 0.0071 0.1856 0.2611
Echinococcus multilocularis snurportin 1 0.0308 1 1
Schistosoma mansoni endothelin-converting enzyme-related 0.0024 0.0255 0.0255
Echinococcus granulosus acetylcholinesterase 0.0071 0.1856 0.1856
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.2986 0.42
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2534 0.2534
Loa Loa (eye worm) hypothetical protein 0.0104 0.2986 0.2947
Plasmodium falciparum importin beta, putative 0.0029 0.0423 0.395
Loa Loa (eye worm) acetylcholinesterase 1 0.0071 0.1856 0.1811
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.2534 0.2492
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0701 0.655
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.1077 0.1077
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0701 0.2494
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0098 0.2809 0.7839
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0056 0.08
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2534 0.2534
Schistosoma mansoni ap endonuclease 0.0018 0.0056 0.0056
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.005 0.1136 0.1136
Schistosoma mansoni hypothetical protein 0.0048 0.1077 0.1077
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0024 0.0255 0.0255
Schistosoma mansoni inositol monophosphatase 0.0037 0.0701 0.0701
Onchocerca volvulus 0.0049 0.1106 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.1856 0.1811
Entamoeba histolytica hypothetical protein 0.0036 0.0685 0.9754
Schistosoma mansoni inositol monophosphatase 0.0037 0.0701 0.0701
Brugia malayi glutathione reductase 0.0048 0.107 0.1505
Loa Loa (eye worm) hypothetical protein 0.0098 0.2809 0.2769
Schistosoma mansoni hypothetical protein 0.0026 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0073 0.1928 0.1883
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.005 0.1136 0.1136
Schistosoma mansoni ap endonuclease 0.0018 0.0056 0.0056
Brugia malayi Importin beta-1 subunit 0.0029 0.0423 0.0594
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.3167 0.8837
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0701 0.2494
Loa Loa (eye worm) hypothetical protein 0.0074 0.1987 0.1942
Toxoplasma gondii peptidase family M13 protein 0.0098 0.2809 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0056 0.0156
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0701 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.1077 0.1077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2534 0.2534
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0056 0.0524
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0235 0.3359
Entamoeba histolytica hypothetical protein 0.0036 0.0685 0.9754
Echinococcus granulosus importin subunit beta 1 0.0029 0.0423 0.0423
Loa Loa (eye worm) carboxylesterase 0.0071 0.1856 0.1811
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0423 0.1504
Schistosoma mansoni hypothetical protein 0.0048 0.1077 0.1077
Toxoplasma gondii exonuclease III APE 0.0018 0.0056 0.02
Loa Loa (eye worm) hypothetical protein 0.0049 0.1106 0.1055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2534 0.2534
Schistosoma mansoni neprilysin-2 (M13 family) 0.005 0.1136 0.1136
Plasmodium vivax importin-beta 2, putative 0.0029 0.0423 0.395
Schistosoma mansoni hypothetical protein 0.0026 0.0314 0.0314
Entamoeba histolytica hypothetical protein 0.0023 0.0235 0.2782
Leishmania major trypanothione reductase 0.0048 0.107 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.1077 0.1516
Toxoplasma gondii thioredoxin reductase 0.0048 0.107 0.3808
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.4631 0.6514
Schistosoma mansoni hypothetical protein 0.0048 0.1077 0.1077
Loa Loa (eye worm) glutathione reductase 0.0048 0.107 0.1019
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.3167 0.8837
Schistosoma mansoni hypothetical protein 0.0026 0.0314 0.0314
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0056 0.0524
Loa Loa (eye worm) hypothetical protein 0.0073 0.1928 0.1883
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0701 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0423 0.395
Plasmodium vivax glutathione reductase, putative 0.0048 0.107 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.2809 0.2769
Schistosoma mansoni neprilysin 0.0026 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0074 0.1987 0.1942
Loa Loa (eye worm) hypothetical protein 0.0073 0.1928 0.1883
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.005 0.1136 0.1136
Trypanosoma brucei trypanothione reductase 0.0048 0.107 1
Brugia malayi Inositol-1 0.0037 0.0701 0.0986
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0056 0.0524
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.3584 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0685 0.0685
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.107 0.107
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2534 0.2534
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0056 0.02
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0056 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0701 0.655
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0701 0.0701
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0255 0.0255
Schistosoma mansoni hypothetical protein 0.0048 0.1077 0.1077
Entamoeba histolytica hypothetical protein 0.0036 0.0685 0.9754
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.3584 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.2534 0.3565
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0701 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0423 0.395
Entamoeba histolytica hypothetical protein 0.0036 0.0685 0.9754
Schistosoma mansoni hypothetical protein 0.0026 0.0314 0.0314
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0026 0.0314 0.0314
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0235 0.3359
Echinococcus multilocularis endothelin converting enzyme 1 0.0098 0.2809 0.2809
Plasmodium falciparum thioredoxin reductase 0.0048 0.107 1
Loa Loa (eye worm) peptidase family M13 containing protein 0.0073 0.1928 0.1883
Echinococcus multilocularis GPCR, family 2 0.0048 0.1077 0.1077
Schistosoma mansoni hypothetical protein 0.0026 0.0314 0.0314
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0701 0.655
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0056 0.0079
Schistosoma mansoni Nep2 peptidase (M13 family) 0.005 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0073 0.1928 0.1883
Schistosoma mansoni hypothetical protein 0.0026 0.0314 0.0314
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0056 0.0524
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0056 0.0524
Mycobacterium ulcerans zinc metalloprotease 0.0098 0.2809 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0701 1
Brugia malayi hypothetical protein 0.0036 0.0685 0.0963
Brugia malayi Latrophilin receptor protein 2 0.0048 0.1077 0.1516
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0098 0.2809 0.2809
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.3167 0.8618
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.107 0.1019
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.107 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.3584 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.1077 0.1077
Loa Loa (eye worm) hypothetical protein 0.0048 0.1077 0.1027
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0056 0.08
Loa Loa (eye worm) hypothetical protein 0.0071 0.1856 0.1811

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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