Detailed information for compound 879032

Basic information

Technical information
  • TDR Targets ID: 879032
  • Name: 4-bromo-5-[(2Z)-2-[(3-methylphenyl)methyliden e]hydrazinyl]-2H-pyridazin-3-one
  • MW: 307.146 | Formula: C12H11BrN4O
  • H donors: 2 H acceptors: 3 LogP: 2.5 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)C=NNc1cnnc(c1Br)O
  • InChi: 1S/C12H11BrN4O/c1-8-3-2-4-9(5-8)6-14-16-10-7-15-17-12(18)11(10)13/h2-7H,1H3,(H2,16,17,18)/b14-6-
  • InChiKey: ZDJQAQSAKCVDFR-NSIKDUERSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-bromo-5-[(N'Z)-N'-[(3-methylphenyl)methylene]hydrazino]-2H-pyridazin-3-one
  • 4-bromo-5-[(N'Z)-N'-(3-methylbenzylidene)hydrazino]-2H-pyridazin-3-one
  • ST5198560

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine GPCR 0.0027 0.0509 0.1047
Echinococcus multilocularis g-protein coupled receptor 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.003 0.0602 0.0997
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Schistosoma mansoni hypothetical protein 0.017 0.4861 1
Onchocerca volvulus 0.0027 0.0509 0.0735
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0027 0.0509 0.1047
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0509 0.1047
Schistosoma mansoni neuropeptide receptor 0.0027 0.0509 0.1047
Echinococcus granulosus dro:myosuppressin receptor 0.0027 0.0509 0.0509
Echinococcus multilocularis G-protein coupled receptor, putative 0.0027 0.0509 0.0509
Brugia malayi Pre-SET motif family protein 0.0208 0.6041 1
Onchocerca volvulus 0.0027 0.0509 0.0735
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0027 0.0509 0.0509
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0027 0.0509 0.1047
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0509 0.0509
Echinococcus granulosus 7TM GPCR rhodopsin 0.0027 0.0509 0.0509
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0509 0.0509
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0509 0.0842
Onchocerca volvulus 0.0027 0.0509 0.0735
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0602 0.0602
Echinococcus granulosus g protein coupled receptor 0.0027 0.0509 0.0509
Schistosoma mansoni neuropeptide receptor 0.0027 0.0509 0.1047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0509 0.0509
Schistosoma mansoni amine GPCR 0.0027 0.0509 0.1047
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Brugia malayi Serotonin receptor 0.0027 0.0509 0.0842
Schistosoma mansoni opsin-like receptor 0.0027 0.0509 0.1047
Brugia malayi follicle stimulating hormone receptor 0.0027 0.0509 0.0842
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus granulosus 7tm_1 domain containing protein 0.0027 0.0509 0.0509
Echinococcus granulosus geminin 0.017 0.4861 0.4861
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.005 0.12 0.1987
Onchocerca volvulus Neuropeptide F receptor homolog 0.0027 0.0509 0.0735
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0789 0.0789
Echinococcus granulosus alpha 1A adrenergic receptor 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus multilocularis geminin 0.017 0.4861 0.4861
Schistosoma mansoni growth hormone secretagogue receptor 0.0027 0.0509 0.1047
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0509 0.1047
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus granulosus tachykinin peptides receptor 99D 0.0027 0.0509 0.0509
Schistosoma mansoni neuropeptide receptor 0.0027 0.0509 0.1047
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0509 0.0842
Entamoeba histolytica hypothetical protein 0.0036 0.0789 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0027 0.0509 0.1047
Brugia malayi Melatonin receptor type 1A 0.0027 0.0509 0.0842
Echinococcus multilocularis sex peptide receptor 0.0027 0.0509 0.0509
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0509 0.1047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0027 0.0509 0.0509
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0509 0.0509
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.0509 0.0842
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0509 0.0509
Brugia malayi G-protein coupled receptor 0.0027 0.0509 0.0842
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0509 0.0509
Echinococcus multilocularis serotonin receptor 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0027 0.0509 0.1047
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0509 0.0509
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Onchocerca volvulus 0.0027 0.0509 0.0735
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Brugia malayi neuropeptide F receptor 0.0027 0.0509 0.0842
Brugia malayi hypothetical protein 0.0027 0.0509 0.0842
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0602 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0509 0.1047
Echinococcus multilocularis somatostatin receptor 0.0027 0.0509 0.0509
Brugia malayi AKH receptor 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.0509 0.0842
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0509 0.1047
Schistosoma mansoni amine GPCR 0.0027 0.0509 0.1047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0509 0.1047
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0027 0.0509 0.0509
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0509 0.0509
Onchocerca volvulus 0.0027 0.0509 0.0735
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0602 0.0602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2499 0.514
Schistosoma mansoni opsin-like receptor 0.0027 0.0509 0.1047
Brugia malayi Dopamine receptor protein 2 0.0027 0.0509 0.0842
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.2499 0.2499
Brugia malayi hypothetical protein 0.0027 0.0509 0.0842
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0509 0.0509
Echinococcus multilocularis neuropeptide s receptor 0.0027 0.0509 0.0509
Echinococcus multilocularis tumor protein p63 0.0338 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Brugia malayi hypothetical protein 0.0027 0.0509 0.0842
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus granulosus sex peptide receptor 0.0027 0.0509 0.0509
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0509 0.1047
Echinococcus granulosus neuropeptide s receptor 0.0027 0.0509 0.0509
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0602 0.1239
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.0509 0.0842
Schistosoma mansoni alpha-1 adrenergic receptor 0.0027 0.0509 0.1047
Onchocerca volvulus 0.0027 0.0509 0.0735
Onchocerca volvulus 0.0027 0.0509 0.0735
Echinococcus multilocularis G protein coupled receptor 139 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.0509 0.0842
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.0509 0.0842
Onchocerca volvulus 0.0027 0.0509 0.0735
Schistosoma mansoni hypothetical protein 0.0027 0.0509 0.1047
Onchocerca volvulus 0.0027 0.0509 0.0735
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0027 0.0509 0.0509
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Brugia malayi hypothetical protein 0.0027 0.0509 0.0842
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0509 0.1047
Brugia malayi sulfakinin receptor protein 0.0027 0.0509 0.0842
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0509 0.1047
Onchocerca volvulus 0.0027 0.0509 0.0735
Echinococcus multilocularis neuropeptide receptor A26 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Schistosoma mansoni biogenic amine receptor 0.0027 0.0509 0.1047
Echinococcus granulosus neuropeptide receptor 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0027 0.0509 0.1047
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.0509 0.0842
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0569 0.0569
Onchocerca volvulus 0.0027 0.0509 0.0735
Echinococcus granulosus g protein coupled receptor 0.0027 0.0509 0.0509
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.2499 0.4136
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.2499 0.2499
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.6041 1
Brugia malayi hypothetical protein 0.0027 0.0509 0.0842
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0509 0.0509
Brugia malayi hypothetical protein 0.0027 0.0509 0.0842
Schistosoma mansoni adenoreceptor 0.0027 0.0509 0.1047
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0509 0.0842
Onchocerca volvulus 0.005 0.12 0.1735
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0027 0.0509 0.1047
Brugia malayi ORL1-like opioid receptor 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0027 0.0509 0.0509
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0027 0.0509 0.0509
Brugia malayi Serotonin receptor 0.0027 0.0509 0.0842
Schistosoma mansoni myosin xvIII 0.0027 0.0509 0.1047
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Brugia malayi hypothetical protein 0.0027 0.0509 0.0842
Onchocerca volvulus 0.0027 0.0509 0.0735
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0509 0.1047
Echinococcus multilocularis orexin receptor type 2 0.0027 0.0509 0.0509
Schistosoma mansoni biogenic amine receptor 0.0027 0.0509 0.1047
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.0509 0.0842
Schistosoma mansoni cellular tumor antigen P53 0.005 0.12 0.247
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Brugia malayi hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus multilocularis allatostatin A receptor 0.0027 0.0509 0.0509
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0509 0.0509
Echinococcus granulosus allatostatin A receptor 0.0027 0.0509 0.0509
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0509 0.0509
Schistosoma mansoni amine GPCR 0.0027 0.0509 0.1047
Brugia malayi RE15519p 0.0027 0.0509 0.0842
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0027 0.0509 0.0735
Brugia malayi neuropeptide F receptor 0.0027 0.0509 0.0842
Echinococcus granulosus peptide allatostatin:somatostatin 0.0027 0.0509 0.0509
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0509 0.0509
Schistosoma mansoni hypothetical protein 0.0027 0.0509 0.1047
Schistosoma mansoni hypothetical protein 0.017 0.4861 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0027 0.0509 0.0509
Schistosoma mansoni neuropeptide receptor 0.0027 0.0509 0.1047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0602 0.1239
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Schistosoma mansoni amine GPCR 0.0027 0.0509 0.1047
Onchocerca volvulus 0.0027 0.0509 0.0735
Echinococcus granulosus neuropeptide FF receptor 2 0.0027 0.0509 0.0509
Onchocerca volvulus 0.0027 0.0509 0.0735
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Schistosoma mansoni histamine h1 receptor 0.0027 0.0509 0.1047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0602 0.1239
Echinococcus granulosus hypothetical protein 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.0509 0.0842
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0509 0.1047
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Brugia malayi G protein-coupled receptor 0.0027 0.0509 0.0842
Brugia malayi Dopamine receptor 0.0027 0.0509 0.0842
Brugia malayi hypothetical protein 0.0027 0.0509 0.0842
Trichomonas vaginalis set domain proteins, putative 0.0237 0.6918 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.2499 0.2499
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.0509 0.0842
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0509 0.0509
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0027 0.0509 0.0509
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0509 0.0509
Entamoeba histolytica hypothetical protein 0.0036 0.0789 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0509 0.0509
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0509 0.0509
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0509 0.1047
Echinococcus multilocularis solute carrier family 28 0.0333 0.9837 0.9837
Schistosoma mansoni opsin-like receptor 0.0027 0.0509 0.1047
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Onchocerca volvulus 0.0027 0.0509 0.0735
Echinococcus granulosus fmrfamide receptor 0.0027 0.0509 0.0509
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0027 0.0509 0.1047
Plasmodium vivax SET domain protein, putative 0.003 0.0602 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0027 0.0509 0.0842
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0509 0.0509
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2499 0.514
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.0509 0.0842
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0027 0.0509 0.0509
Brugia malayi G-protein coupled receptor 0.0027 0.0509 0.0842
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.2499 0.2499
Onchocerca volvulus 0.003 0.0602 0.0871
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0602 0.1239
Schistosoma mansoni hypothetical protein 0.0027 0.0509 0.1047
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0509 0.1047
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0509 0.0509
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0509 0.1047
Brugia malayi hypothetical protein 0.0036 0.0789 0.1306
Brugia malayi GnHR receptor homolog 0.0027 0.0509 0.0842
Schistosoma mansoni hypothetical protein 0.0027 0.0509 0.1047
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus granulosus serotonin receptor 0.0027 0.0509 0.0509
Brugia malayi Dopamine receptor protein 1 0.0027 0.0509 0.0842
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Entamoeba histolytica hypothetical protein 0.0036 0.0789 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0509 0.1047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0027 0.0509 0.1047
Brugia malayi putative neuropeptide receptor 0.0027 0.0509 0.0842
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0333 0.9837 0.9837
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0509 0.0509
Echinococcus granulosus somatostatin receptor 0.0027 0.0509 0.0509
Onchocerca volvulus 0.0237 0.6918 1
Echinococcus granulosus solute carrier family 28 0.0333 0.9837 0.9837
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.2499 0.4136
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0509 0.0509
Echinococcus granulosus orexin receptor type 2 0.0027 0.0509 0.0509
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0509 0.0509
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0217 0.6308 0.6308
Echinococcus multilocularis neuropeptide FF receptor 2 0.0027 0.0509 0.0509
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0509 0.0509
Echinococcus granulosus neuropeptide receptor 0.0027 0.0509 0.0509
Echinococcus multilocularis serotonin receptor 0.0027 0.0509 0.0509
Brugia malayi larval opioid receptor 0.0027 0.0509 0.0842
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0509 0.0842
Schistosoma mansoni hypothetical protein 0.0036 0.0789 0.1624
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0602 0.0602
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0333 0.9837 0.9837
Brugia malayi Pre-SET motif family protein 0.003 0.0602 0.0997
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0333 0.9837 0.9837
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0789 0.0789
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2499 0.514
Entamoeba histolytica hypothetical protein 0.0036 0.0789 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus granulosus G protein coupled receptor 139 0.0027 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0509 0.0842
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0509 0.0509
Echinococcus multilocularis dro:myosuppressin receptor 0.0027 0.0509 0.0509
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0789 0.1624
Echinococcus granulosus neuropeptide receptor A26 0.0027 0.0509 0.0509
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Schistosoma mansoni biogenic amine receptor 0.0027 0.0509 0.1047
Schistosoma mansoni neuropeptide f receptor 76f 0.0027 0.0509 0.1047
Brugia malayi hypothetical protein 0.0027 0.0509 0.0842
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0509 0.0509
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0509 0.0509
Echinococcus granulosus g-protein coupled receptor 0.0027 0.0509 0.0509
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.0509 0.0842
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0509 0.1047
Onchocerca volvulus 0.0027 0.0509 0.0735
Onchocerca volvulus 0.0027 0.0509 0.0735
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0509 0.1047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0509 0.1047
Echinococcus granulosus g protein coupled receptor 0.0027 0.0509 0.0509

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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