Detailed information for compound 879894

Basic information

Technical information
  • TDR Targets ID: 879894
  • Name: 3-(3-dimethylamino-2,2-dimethylpropyl)-2-(5-m ethylthiophen-2-yl)-1,3-thiazolidin-4-one
  • MW: 312.494 | Formula: C15H24N2OS2
  • H donors: 0 H acceptors: 1 LogP: 3.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CC(CN1C(=O)CSC1c1ccc(s1)C)(C)C)C
  • InChi: 1S/C15H24N2OS2/c1-11-6-7-12(20-11)14-17(13(18)8-19-14)10-15(2,3)9-16(4)5/h6-7,14H,8-10H2,1-5H3
  • InChiKey: SKXYORGYORHWSI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(3-dimethylamino-2,2-dimethyl-propyl)-2-(5-methyl-2-thienyl)thiazolidin-4-one
  • 3-(3-dimethylamino-2,2-dimethylpropyl)-2-(5-methyl-2-thienyl)-4-thiazolidinone
  • 3-(3-dimethylamino-2,2-dimethyl-propyl)-2-(5-methylthiophen-2-yl)-1,3-thiazolidin-4-one
  • Oprea1_141958

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Brugia malayi hypothetical protein 0.0147 0.0923 0.0883
Loa Loa (eye worm) hypothetical protein 0.1017 1 1
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0308 0.2598 0.2565
Echinococcus granulosus glycine receptor subunit alpha 1 0.0308 0.2598 1
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0147 0.0923 0.0883
Echinococcus granulosus nAChR subunit 0.0308 0.2598 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0308 0.2598 0.2565
Echinococcus granulosus glycine receptor subunit alpha 1 0.0308 0.2598 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0308 0.2598 0.2598
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0308 0.2598 0.2565
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Brugia malayi hypothetical protein 0.0147 0.0923 0.0883
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0308 0.2598 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0161 0.1065 0.4056
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0308 0.2598 0.2565
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0308 0.2598 0.2598
Brugia malayi Cation transporter family protein 0.0308 0.2598 0.2565
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0308 0.2598 0.2598
Onchocerca volvulus 0.0147 0.0923 0.1468
Loa Loa (eye worm) hypothetical protein 0.0161 0.1065 0.1065
Brugia malayi hypothetical protein 0.0484 0.4438 0.4414
Brugia malayi hypothetical protein 0.0147 0.0923 0.0883
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Brugia malayi hypothetical protein 0.0133 0.0777 0.0737
Onchocerca volvulus 0.0308 0.2598 0.5533
Loa Loa (eye worm) hypothetical protein 0.0161 0.1065 0.1065
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0308 0.2598 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0308 0.2598 0.2565
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0308 0.2598 0.2565
Onchocerca volvulus 0.0161 0.1065 0.1814
Brugia malayi hypothetical protein 0.0147 0.0923 0.0883
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Schistosoma mansoni nAChR subunit 0.0308 0.2598 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0308 0.2598 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0044 0.0095
Loa Loa (eye worm) TK/ROR protein kinase 0.0089 0.0318 0.0318
Echinococcus multilocularis nAChR subunit 0.0161 0.1065 0.4056
Schistosoma mansoni nAChR subunit 0.0308 0.2598 1
Echinococcus multilocularis serotonin receptor 0.0133 0.0773 0.2922
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0161 0.1065 0.1026
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0308 0.2598 0.2565
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0147 0.0923 0.3504
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0308 0.2598 1
Brugia malayi Cation transporter family protein 0.0308 0.2598 0.2565
Loa Loa (eye worm) hypothetical protein 0.087 0.8467 0.8467
Echinococcus granulosus glycine receptor subunit beta 0.0308 0.2598 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0308 0.2598 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0308 0.2598 1
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0308 0.2598 1
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Loa Loa (eye worm) hypothetical protein 0.0484 0.4438 0.4438
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0308 0.2598 0.2565
Plasmodium falciparum cysteine repeat modular protein 1 0.0089 0.0318 0.5
Echinococcus multilocularis glycine receptor subunit beta 0.0308 0.2598 1
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Loa Loa (eye worm) GABA receptor subunit 0.0161 0.1065 0.1065
Onchocerca volvulus 0.0147 0.0923 0.1468
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0308 0.2598 0.2565
Loa Loa (eye worm) hypothetical protein 0.0347 0.3006 0.3006
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0308 0.2598 1
Onchocerca volvulus 0.0484 0.4438 1
Loa Loa (eye worm) hypothetical protein 0.0978 0.9589 0.9589
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0308 0.2598 0.2598
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0591 0.5551 1
Echinococcus granulosus nAChR subunit 0.0161 0.1065 0.4056
Brugia malayi hypothetical protein 0.0147 0.0923 0.0883
Echinococcus multilocularis Protein lozenge 0.0061 0.0023 0.0016
Loa Loa (eye worm) hypothetical protein 0.0161 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0161 0.1065 0.4056
Brugia malayi Protein kinase domain containing protein 0.0089 0.0318 0.0275
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0308 0.2598 0.2598
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Schistosoma mansoni hypothetical protein 0.0089 0.0318 0.1158
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0308 0.2598 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0308 0.2598 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0044 0.0095
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Treponema pallidum cell division protein FtsZ 0.0319 0.2722 0.5
Schistosoma mansoni nAChR subunit 0.0308 0.2598 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0308 0.2598 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Brugia malayi excitatory GABA receptor EXP-1A 0.0308 0.2598 0.2565
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0147 0.0923 0.0883
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0308 0.2598 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0308 0.2598 0.2565
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0308 0.2598 0.2598
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0147 0.0923 0.3504
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0147 0.0923 0.0883
Loa Loa (eye worm) hypothetical protein 0.0161 0.1065 0.1065
Schistosoma mansoni nAChR subunit 0.0147 0.0923 0.3504
Loa Loa (eye worm) hypothetical protein 0.0161 0.1065 0.1065
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0308 0.2598 1
Loa Loa (eye worm) LGC-31 protein 0.0308 0.2598 0.2598
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0308 0.2598 0.2565
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0147 0.0923 0.0923
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0308 0.2598 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0147 0.0923 0.0883
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0161 0.1065 0.1026
Leishmania major hypothetical protein, conserved 0.0089 0.0318 1
Loa Loa (eye worm) runx1 0.0061 0.0023 0.0023
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0147 0.0923 0.3504
Mycobacterium ulcerans cell division protein FtsZ 0.0319 0.2722 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0308 0.2598 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0147 0.0923 0.0883
Entamoeba histolytica hypothetical protein 0.0161 0.1065 0.5
Toxoplasma gondii kringle domain-containing protein 0.0089 0.0318 0.5
Brugia malayi Cell division protein ftsZ 0.0158 0.1034 0.0995
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0319 0.2722 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0133 0.0773 0.2922
Loa Loa (eye worm) acetylcholine receptor protein 0.0147 0.0923 0.0923
Onchocerca volvulus 0.0308 0.2598 0.5533
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Loa Loa (eye worm) hypothetical protein 0.0161 0.1065 0.1065
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0308 0.2598 0.2565
Echinococcus granulosus biogenic amine 5HT receptor 0.0133 0.0773 0.2922
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0044 0.0095
Onchocerca volvulus Putative nachr subunit 0.0308 0.2598 0.5533
Schistosoma mansoni nAChR subunit 0.0308 0.2598 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0319 0.2722 1
Onchocerca volvulus 0.0308 0.2598 0.5533
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0308 0.2598 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.1065 0.1065
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0308 0.2598 1
Mycobacterium leprae cell division protein FtsZ 0.0319 0.2722 0.5
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0308 0.2598 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0161 0.1065 0.4056
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0308 0.2598 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0308 0.2598 0.2565
Loa Loa (eye worm) hypothetical protein 0.0133 0.0773 0.0773
Brugia malayi Kringle domain containing protein 0.0089 0.0318 0.0275
Schistosoma mansoni nAChR subunit 0.0147 0.0923 0.3504
Loa Loa (eye worm) ACC-1 protein 0.0308 0.2598 0.2598
Onchocerca volvulus 0.0161 0.1065 0.1814
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0147 0.0923 0.3504
Echinococcus multilocularis tissue type plasminogen activator 0.0089 0.0318 0.1158
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0128 0.0724 0.0724
Echinococcus multilocularis glycine receptor subunit beta 0.0308 0.2598 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0147 0.0923 0.0923
Brugia malayi Cell division protein ftsZ 0.0153 0.0989 0.0949
Onchocerca volvulus 0.0308 0.2598 0.5533
Schistosoma mansoni nAChR subunit 0.0308 0.2598 1
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.0318 0.5
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Schistosoma mansoni nAChR subunit 0.0308 0.2598 1
Echinococcus multilocularis serotonin receptor 0.0133 0.0773 0.2922
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0147 0.0923 0.0883
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0308 0.2598 1
Loa Loa (eye worm) ACC-1 protein 0.0308 0.2598 0.2598
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0161 0.1065 0.1026
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0147 0.0923 0.3504
Echinococcus granulosus glycine receptor subunit beta 0.0308 0.2598 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0318 0.0318
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0161 0.1065 0.1026
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0308 0.2598 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Schistosoma mansoni neurotransmitter gated ion channel 0.0147 0.0923 0.3504
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Loa Loa (eye worm) hypothetical protein 0.0133 0.0773 0.0773
Onchocerca volvulus 0.0308 0.2598 0.5533
Schistosoma mansoni neurotransmitter gated ion channel 0.0147 0.0923 0.3504
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0308 0.2598 1
Brugia malayi Cation transporter family protein 0.0308 0.2598 0.2565
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0161 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0308 0.2598 1
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Schistosoma mansoni lozenge 0.0061 0.0023 0.0016
Echinococcus granulosus glycine receptor subunit alpha 1 0.0308 0.2598 1
Schistosoma mansoni nAChR subunit 0.0308 0.2598 1
Echinococcus multilocularis nAChR subunit 0.0308 0.2598 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.4438 0.4438
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Brugia malayi Receptor family ligand binding region containing protein 0.0128 0.0724 0.0683
Schistosoma mansoni acetylcholine receptor-related 0.0147 0.0923 0.3504
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0308 0.2598 0.2565
Onchocerca volvulus 0.0308 0.2598 0.5533
Loa Loa (eye worm) hypothetical protein 0.0147 0.0923 0.0923
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0308 0.2598 1
Schistosoma mansoni acetylcholine receptor subunit beta 0.0147 0.0923 0.3504
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0308 0.2598 0.2565
Echinococcus granulosus tissue type plasminogen activator 0.0089 0.0318 0.1158
Loa Loa (eye worm) hypothetical protein 0.0308 0.2598 0.2598
Onchocerca volvulus 0.0147 0.0923 0.1468

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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