Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5243 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5243 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.5243 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5243 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.198 | 0.364 | 0.3279 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2707 | 0.5057 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5243 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0124 | 0.0024 | 0.0024 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.2707 | 0.5057 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.127 | 0.2257 | 0.219 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2707 | 0.5057 | 1 |
Echinococcus multilocularis | AMP deaminase 2 | 0.2707 | 0.5057 | 0.4242 |
Schistosoma mansoni | adenosine deaminase-related | 0.5243 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3264 | 0.6142 | 0.5923 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0819 | 0.1379 | 0.1304 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.5243 | 1 | 1 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.2707 | 0.5057 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.2707 | 0.5057 | 0.2228 |
Leishmania major | AMP deaminase, putative | 0.2707 | 0.5057 | 0.2228 |
Loa Loa (eye worm) | hypothetical protein | 0.3264 | 0.6142 | 0.5923 |
Plasmodium falciparum | adenosine deaminase | 0.5243 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.5243 | 1 | 0.5 |
Leishmania major | AMP deaminase, putative,adenosine monophosphate deaminase-like protein | 0.2707 | 0.5057 | 0.2228 |
Treponema pallidum | adenosine deaminase | 0.5243 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3264 | 0.6142 | 0.5923 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.5243 | 1 | 1 |
Echinococcus granulosus | AMP deaminase 2 | 0.2707 | 0.5057 | 0.3616 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0124 | 0.0024 | 0.0024 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.5243 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.2707 | 0.5057 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.2707 | 0.5057 | 1 |
Leishmania major | AMP deaminase, putative,amp deaminase-like protein | 0.2707 | 0.5057 | 0.2228 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0124 | 0.0024 | 0.0024 |
Trypanosoma brucei | AMP deaminase, putative | 0.2707 | 0.5057 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.5243 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.2707 | 0.5057 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2707 | 0.5057 | 1 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.127 | 0.2257 | 0.098 |
Leishmania major | adenosine monophosphate deaminase, putative,AMP deaminase, putative | 0.2707 | 0.5057 | 0.2228 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0124 | 0.0024 | 0.0024 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.5243 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2707 | 0.5057 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.2707 | 0.5057 | 0.4776 |
Schistosoma mansoni | hypothetical protein | 0.127 | 0.2257 | 0.219 |
Entamoeba histolytica | adenosine deaminase, putative | 0.5243 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.0624 | 0.0091 |
Echinococcus multilocularis | adenosine deaminase | 0.5243 | 1 | 1 |
Schistosoma mansoni | AMP deaminase | 0.2707 | 0.5057 | 0.5014 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.0579 | 0.0043 |
Echinococcus granulosus | adenosine deaminase | 0.5243 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.2707 | 0.5057 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.127 | 0.2257 | 0.1817 |
Leishmania major | adenine aminohydrolase | 0.5243 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3264 | 0.6142 | 0.5923 |
Loa Loa (eye worm) | hypothetical protein | 0.0727 | 0.12 | 0.0699 |
Schistosoma mansoni | adenosine deaminase | 0.5243 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.