Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, CDC7 | 0.118923 | 1 | 1 |
Trypanosoma brucei | Mitogen-activated protein kinase 10, putative | 0.00183008 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.00183008 | 0 | 0.5 |
Schistosoma mansoni | kinase | 0.00657858 | 0.0405533 | 0.0405533 |
Trypanosoma cruzi | serine/threonine protein kinase, putative | 0.00183008 | 0 | 0.5 |
Plasmodium falciparum | MO15-related protein kinase | 0.00183008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.032557 | 0.262415 | 0.262415 |
Onchocerca volvulus | 0.118923 | 1 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.118923 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.00765933 | 0.0497831 | 0.0497831 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.00183008 | 0 | 0.5 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.00183008 | 0 | 0.5 |
Brugia malayi | cyclin-dependent kinase 9 | 0.00657858 | 0.0405533 | 0.0405533 |
Entamoeba histolytica | protein kinase domain containing protein | 0.00657858 | 0.0405533 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.118923 | 1 | 1 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.00183008 | 0 | 0.5 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.118923 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.00657858 | 0.0405533 | 0.0405533 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.00657858 | 0.0405533 | 0.0405533 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.00183008 | 0 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.00765933 | 0.0497831 | 0.0497831 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.00183008 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.118923 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK9 protein kinase | 0.00657858 | 0.0405533 | 0.0405533 |
Onchocerca volvulus | 0.118923 | 1 | 0.5 | |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.00183008 | 0 | 0.5 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.118923 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00657858 | 0.0405533 | 0.0405533 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.118923 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.118923 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.118923 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.17 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | 1.1719 uM | ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | = 1.21 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | 1.2141 uM | ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
Percent growth inhibition (functional) | = 103.4 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 110.2 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.