Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nAChR subunit | 0.0308 | 0.2598 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0308 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0484 | 0.4438 | 0.4438 |
Echinococcus multilocularis | nAChR subunit | 0.0308 | 0.2598 | 1 |
Schistosoma mansoni | acetylcholine receptor-related | 0.0147 | 0.0923 | 0.3504 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0128 | 0.0724 | 0.0683 |
Brugia malayi | Cation transporter family protein | 0.0308 | 0.2598 | 0.2565 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0147 | 0.0923 | 0.3504 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0308 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1065 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Schistosoma mansoni | lozenge | 0.0061 | 0.0023 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0308 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0089 | 0.0318 | 0.1158 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0308 | 0.2598 | 0.2565 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Onchocerca volvulus | 0.0147 | 0.0923 | 0.1468 | |
Onchocerca volvulus | 0.0308 | 0.2598 | 0.5533 | |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0308 | 0.2598 | 0.2565 |
Schistosoma mansoni | acetylcholine receptor subunit beta | 0.0147 | 0.0923 | 0.3504 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0308 | 0.2598 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0308 | 0.2598 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0147 | 0.0923 | 0.0883 |
Echinococcus multilocularis | serotonin receptor | 0.0133 | 0.0773 | 0.2922 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0308 | 0.2598 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0308 | 0.2598 | 1 |
Brugia malayi | Cell division protein ftsZ | 0.0153 | 0.0989 | 0.0949 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0147 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0089 | 0.0318 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0308 | 0.2598 | 1 |
Onchocerca volvulus | 0.0308 | 0.2598 | 0.5533 | |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0147 | 0.0923 | 0.3504 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0773 | 0.0773 |
Onchocerca volvulus | 0.0308 | 0.2598 | 0.5533 | |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0147 | 0.0923 | 0.3504 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0308 | 0.2598 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0308 | 0.2598 | 0.2598 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0161 | 0.1065 | 0.1026 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0161 | 0.1065 | 0.1026 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0318 | 0.0318 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0308 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1065 | 0.1065 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0308 | 0.2598 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0308 | 0.2598 | 1 |
Mycobacterium leprae | cell division protein FtsZ | 0.0319 | 0.2722 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0308 | 0.2598 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0308 | 0.2598 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0161 | 0.1065 | 0.4056 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.0044 | 0.0095 |
Onchocerca volvulus | Putative nachr subunit | 0.0308 | 0.2598 | 0.5533 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0133 | 0.0773 | 0.2922 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0319 | 0.2722 | 1 |
Onchocerca volvulus | 0.0308 | 0.2598 | 0.5533 | |
Schistosoma mansoni | nAChR subunit | 0.0308 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Echinococcus granulosus | gamma aminobutyric acid receptor subunit | 0.0147 | 0.0923 | 0.3504 |
Onchocerca volvulus | 0.0161 | 0.1065 | 0.1814 | |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0089 | 0.0318 | 0.1158 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0128 | 0.0724 | 0.0724 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0308 | 0.2598 | 0.2565 |
Schistosoma mansoni | nAChR subunit | 0.0147 | 0.0923 | 0.3504 |
Brugia malayi | Kringle domain containing protein | 0.0089 | 0.0318 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0773 | 0.0773 |
Loa Loa (eye worm) | ACC-1 protein | 0.0308 | 0.2598 | 0.2598 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0161 | 0.1065 | 0.1026 |
Loa Loa (eye worm) | runx1 | 0.0061 | 0.0023 | 0.0023 |
Leishmania major | hypothetical protein, conserved | 0.0089 | 0.0318 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0308 | 0.2598 | 1 |
Echinococcus multilocularis | gamma aminobutyric acid receptor subunit | 0.0147 | 0.0923 | 0.3504 |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0319 | 0.2722 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0147 | 0.0923 | 0.0883 |
Entamoeba histolytica | hypothetical protein | 0.0161 | 0.1065 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0147 | 0.0923 | 0.0883 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0308 | 0.2598 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0147 | 0.0923 | 0.3504 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1065 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1065 | 0.1065 |
Loa Loa (eye worm) | LGC-31 protein | 0.0308 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | neuronal acetylcholine receptor protein | 0.0147 | 0.0923 | 0.0923 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0308 | 0.2598 | 0.2565 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0308 | 0.2598 | 1 |
Brugia malayi | Neuronal acetylcholine receptor protein, alpha-2 chain precursor | 0.0147 | 0.0923 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1065 | 0.1065 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0308 | 0.2598 | 0.2565 |
Toxoplasma gondii | kringle domain-containing protein | 0.0089 | 0.0318 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0133 | 0.0773 | 0.2922 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0319 | 0.2722 | 0.5 |
Brugia malayi | Cell division protein ftsZ | 0.0158 | 0.1034 | 0.0995 |
Loa Loa (eye worm) | acetylcholine receptor protein | 0.0147 | 0.0923 | 0.0923 |
Onchocerca volvulus | 0.0308 | 0.2598 | 0.5533 | |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0308 | 0.2598 | 0.2598 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0308 | 0.2598 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.0318 | 0.1158 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0308 | 0.2598 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.0044 | 0.0095 |
Echinococcus multilocularis | Protein lozenge | 0.0061 | 0.0023 | 0.0016 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0161 | 0.1065 | 0.4056 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1065 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Brugia malayi | Protein kinase domain containing protein | 0.0089 | 0.0318 | 0.0275 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0308 | 0.2598 | 1 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0308 | 0.2598 | 0.2565 |
Brugia malayi | Acetylcholine receptor protein, alpha-like chain 1 precursor | 0.0147 | 0.0923 | 0.0883 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit type | 0.0147 | 0.0923 | 0.3504 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0308 | 0.2598 | 0.2565 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0308 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Treponema pallidum | cell division protein FtsZ | 0.0319 | 0.2722 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0308 | 0.2598 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0308 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0308 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0484 | 0.4438 | 0.4438 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0308 | 0.2598 | 0.2565 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0089 | 0.0318 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0308 | 0.2598 | 1 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0147 | 0.0923 | 0.3504 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Brugia malayi | Cation transporter family protein | 0.0308 | 0.2598 | 0.2565 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0308 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0308 | 0.2598 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0308 | 0.2598 | 1 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0308 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.087 | 0.8467 | 0.8467 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | hypothetical protein | 0.0978 | 0.9589 | 0.9589 |
Onchocerca volvulus | 0.0484 | 0.4438 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Plasmodium vivax | tryptophan-rich antigen (Pv-fam-a) | 0.0591 | 0.5551 | 1 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0308 | 0.2598 | 0.2598 |
Brugia malayi | hypothetical protein | 0.0147 | 0.0923 | 0.0883 |
Echinococcus granulosus | nAChR subunit | 0.0161 | 0.1065 | 0.4056 |
Onchocerca volvulus | 0.0147 | 0.0923 | 0.1468 | |
Loa Loa (eye worm) | GABA receptor subunit | 0.0161 | 0.1065 | 0.1065 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.3006 | 0.3006 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0308 | 0.2598 | 0.2565 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0308 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0308 | 0.2598 | 0.2565 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0308 | 0.2598 | 0.2565 |
Brugia malayi | hypothetical protein | 0.0147 | 0.0923 | 0.0883 |
Onchocerca volvulus | 0.0161 | 0.1065 | 0.1814 | |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Onchocerca volvulus | 0.0308 | 0.2598 | 0.5533 | |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1065 | 0.1065 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0308 | 0.2598 | 1 |
Echinococcus multilocularis | nAChR subunit | 0.0161 | 0.1065 | 0.4056 |
Echinococcus multilocularis | serotonin receptor | 0.0133 | 0.0773 | 0.2922 |
Schistosoma mansoni | nAChR subunit | 0.0308 | 0.2598 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0161 | 0.1065 | 0.1026 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0308 | 0.2598 | 0.2565 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Schistosoma mansoni | nAChR subunit | 0.0308 | 0.2598 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0063 | 0.0044 | 0.0095 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0089 | 0.0318 | 0.0318 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0308 | 0.2598 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0308 | 0.2598 | 0.2565 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0308 | 0.2598 | 0.2565 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0308 | 0.2598 | 0.2598 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0308 | 0.2598 | 1 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0308 | 0.2598 | 1 |
Brugia malayi | hypothetical protein | 0.0147 | 0.0923 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | hypothetical protein | 0.1017 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0147 | 0.0923 | 0.0883 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0308 | 0.2598 | 0.2565 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0147 | 0.0923 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.2598 | 0.2598 |
Echinococcus granulosus | nAChR subunit | 0.0308 | 0.2598 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0308 | 0.2598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1065 | 0.1065 |
Onchocerca volvulus | 0.0147 | 0.0923 | 0.1468 | |
Brugia malayi | hypothetical protein | 0.0484 | 0.4438 | 0.4414 |
Brugia malayi | hypothetical protein | 0.0147 | 0.0923 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0923 | 0.0923 |
Brugia malayi | hypothetical protein | 0.0133 | 0.0777 | 0.0737 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0161 | 0.1065 | 0.4056 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0308 | 0.2598 | 0.2565 |
Brugia malayi | Cation transporter family protein | 0.0308 | 0.2598 | 0.2565 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0308 | 0.2598 | 0.2598 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0308 | 0.2598 | 0.2598 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.