Detailed information for compound 885226

Basic information

Technical information
  • TDR Targets ID: 885226
  • Name: N-(2-methylsulfanylphenyl)-1,5-dioxa-9-azaspi ro[5.5]undecane-9-carboxamide
  • MW: 322.422 | Formula: C16H22N2O3S
  • H donors: 1 H acceptors: 1 LogP: 1.93 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccccc1NC(=O)N1CCC2(CC1)OCCCO2
  • InChi: 1S/C16H22N2O3S/c1-22-14-6-3-2-5-13(14)17-15(19)18-9-7-16(8-10-18)20-11-4-12-21-16/h2-3,5-6H,4,7-12H2,1H3,(H,17,19)
  • InChiKey: NWQQEKGMMKOGPO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(methylthio)phenyl]-1,5-dioxa-9-azaspiro[5.5]undecane-9-carboxamide
  • Oprea1_262329

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.011 0.1321 0.127
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0059 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.011 0.1321 0.1321
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.011 0.1321 0.1321
Echinococcus multilocularis G protein coupled receptor 139 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus multilocularis neuropeptides capa receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.011 0.1321 0.1321
Echinococcus multilocularis g protein coupled receptor 0.011 0.1321 0.1321
Schistosoma mansoni amine GPCR 0.011 0.1321 0.1321
Echinococcus multilocularis sex peptide receptor 0.011 0.1321 0.1321
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.011 0.1321 0.1321
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.011 0.1321 0.1321
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.011 0.1321 0.1321
Echinococcus multilocularis neuropeptide receptor A26 0.011 0.1321 0.1321
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0078 0.086 0.0806
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1321 0.1321
Schistosoma mansoni hypothetical protein 0.011 0.1321 0.1321
Schistosoma mansoni neuropeptide F-like receptor 0.011 0.1321 0.1321
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.011 0.1321 0.127
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.011 0.1321 0.1321
Schistosoma mansoni glutamate receptor NMDA 0.006 0.0595 0.0595
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0023 0.0058 0.0058
Echinococcus multilocularis G-protein coupled receptor, putative 0.011 0.1321 0.1321
Schistosoma mansoni amine GPCR 0.011 0.1321 0.1321
Echinococcus multilocularis neuropeptide Y receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus multilocularis allatostatin A receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Brugia malayi Serotonin/octopamine receptor family protein 7 0.011 0.1321 0.127
Schistosoma mansoni neuropeptide receptor 0.011 0.1321 0.1321
Echinococcus granulosus nmda type glutamate receptor 0.0066 0.0689 0.0689
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1321 0.1321
Loa Loa (eye worm) melatonin receptor type 1A 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0048 0.042 0.5
Brugia malayi hypothetical protein 0.011 0.1321 0.127
Giardia lamblia Ceramide glucosyltransferase 0.0322 0.4386 0.5
Schistosoma mansoni opsin-like receptor 0.011 0.1321 0.1321
Echinococcus granulosus serotonin receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) neuropeptide F receptor 0.011 0.1321 0.127
Echinococcus granulosus neuropeptide receptor 0.011 0.1321 0.1321
Echinococcus granulosus peptide allatostatin:somatostatin 0.011 0.1321 0.1321
Brugia malayi ORL1-like opioid receptor 0.011 0.1321 0.127
Echinococcus granulosus g protein coupled receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.006 0.0595 0.0595
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.011 0.1321 0.1321
Brugia malayi Serotonin receptor 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Schistosoma mansoni neuropeptide receptor 0.011 0.1321 0.1321
Echinococcus multilocularis neuropeptide receptor 0.011 0.1321 0.1321
Echinococcus granulosus tm gpcr rhodopsin 0.011 0.1321 0.1321
Echinococcus granulosus neuropeptides capa receptor 0.011 0.1321 0.1321
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.006 0.0595 0.0595
Leishmania major cytochrome p450-like protein 0.0037 0.0261 1
Brugia malayi Serotonin receptor 0.011 0.1321 0.127
Echinococcus multilocularis orexin receptor type 2 0.011 0.1321 0.1321
Echinococcus multilocularis neuropeptide Y receptor 0.011 0.1321 0.1321
Echinococcus multilocularis g protein coupled receptor 0.011 0.1321 0.1321
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0058 0.0058
Echinococcus granulosus hypothetical protein 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Schistosoma mansoni amine GPCR 0.011 0.1321 0.1321
Echinococcus granulosus g protein coupled receptor 0.011 0.1321 0.1321
Brugia malayi AKH receptor 0.011 0.1321 0.127
Echinococcus granulosus biogenic amine 5HT receptor 0.011 0.1321 0.1321
Schistosoma mansoni glutamate receptor kainate 0.005 0.0457 0.0457
Brugia malayi Glutamate receptor 2 precursor 0.005 0.0457 0.0401
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1321 0.1321
Echinococcus granulosus neuropeptide FF receptor 2 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.011 0.1321 0.1321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1321 0.1321
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0023 0.0058 0.0058
Echinococcus granulosus g protein coupled receptor 0.011 0.1321 0.1321
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1321 0.1321
Echinococcus multilocularis ceramide glucosyltransferase 0.071 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1321 0.1321
Echinococcus multilocularis glutamate receptor 2 0.0041 0.0326 0.0326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1321 0.1321
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.0963 0.0963
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1321 0.1321
Echinococcus granulosus thyrotropin releasing hormone receptor 0.011 0.1321 0.1321
Echinococcus granulosus 7TM GPCR rhodopsin 0.011 0.1321 0.1321
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0785 0.5
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0048 0.042 1
Echinococcus multilocularis dro:myosuppressin receptor 0.011 0.1321 0.1321
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.006 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus granulosus neuropeptide s receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Brugia malayi hypothetical protein 0.011 0.1321 0.127
Brugia malayi hypothetical protein 0.011 0.1321 0.127
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1321 0.1321
Echinococcus multilocularis serotonin receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.011 0.1321 0.127
Schistosoma mansoni ceramide glucosyltransferase 0.071 1 1
Echinococcus granulosus allatostatin A receptor 0.011 0.1321 0.1321
Schistosoma mansoni biogenic amine (5HT) receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.011 0.1321 0.1321
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.011 0.1321 0.127
Loa Loa (eye worm) ceramide glucosyltransferase 0.071 1 1
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.071 1 1
Echinococcus granulosus neuropeptide Y receptor 0.011 0.1321 0.1321
Brugia malayi Glutamate receptor 1 precursor 0.005 0.0457 0.0401
Schistosoma mansoni ceramide glucosyltransferase 0.071 1 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0066 0.0689 0.0689
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus multilocularis glutamate receptor 2 0.005 0.0457 0.0457
Schistosoma mansoni histamine h1 receptor 0.011 0.1321 0.1321
Echinococcus multilocularis neuropeptide receptor 0.011 0.1321 0.1321
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0078 0.086 0.086
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.0963 0.0963
Loa Loa (eye worm) neuropeptide F receptor 0.011 0.1321 0.127
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0261 0.0204
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Brugia malayi neuropeptide F receptor 0.011 0.1321 0.127
Schistosoma mansoni peptide (allatostatin)-like receptor 0.011 0.1321 0.1321
Brugia malayi sulfakinin receptor protein 0.011 0.1321 0.127
Brugia malayi Dopamine receptor protein 2 0.011 0.1321 0.127
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.006 0.0595 0.0595
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0078 0.086 0.0806
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0048 0.042 1
Schistosoma mansoni ATP-binding cassette transporter 0.005 0.0457 0.0457
Echinococcus multilocularis glutamate receptor 2 0.006 0.0595 0.0595
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0058 0.0058
Echinococcus granulosus fmrfamide receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0261 0.0204
Echinococcus multilocularis fmrfamide receptor 0.011 0.1321 0.1321
Brugia malayi RE15519p 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Schistosoma mansoni hypothetical protein 0.011 0.1321 0.1321
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1321 0.1321
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1321 0.1321
Echinococcus granulosus glutamate receptor 2 0.006 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.006 0.0595 0.0595
Schistosoma mansoni hypothetical protein 0.011 0.1321 0.1321
Schistosoma mansoni hypothetical protein 0.011 0.1321 0.1321
Brugia malayi G protein-coupled receptor F59B2.13 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Schistosoma mansoni neuropeptide receptor 0.011 0.1321 0.1321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1321 0.1321
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.006 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.011 0.1321 0.1321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1321 0.1321
Schistosoma mansoni alpha-1 adrenergic receptor 0.011 0.1321 0.1321
Brugia malayi Cytochrome P450 family protein 0.0037 0.0261 0.0204
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.005 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0058 0.0058
Brugia malayi hypothetical protein 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.011 0.1321 0.1321
Brugia malayi Dopamine receptor protein 1 0.011 0.1321 0.127
Echinococcus granulosus neuropeptide receptor 0.011 0.1321 0.1321
Brugia malayi Melatonin receptor type 1A 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus multilocularis g-protein coupled receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1321 0.1321
Brugia malayi Cytochrome P450 family protein 0.0037 0.0261 0.0204
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Brugia malayi larval opioid receptor 0.011 0.1321 0.127
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.011 0.1321 0.127
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.006 0.0595 0.0595
Echinococcus granulosus alpha 1A adrenergic receptor 0.011 0.1321 0.1321
Brugia malayi GnHR receptor homolog 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0261 0.5594
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0078 0.086 0.086
Echinococcus granulosus glutamate receptor 2 0.0041 0.0326 0.0326
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.0051
Echinococcus granulosus neuropeptides capa receptor 0.011 0.1321 0.1321
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.011 0.1321 0.127
Brugia malayi G-protein coupled receptor 0.011 0.1321 0.127
Schistosoma mansoni glutamate receptor kainate 0.005 0.0457 0.0457
Schistosoma mansoni biogenic amine receptor 0.011 0.1321 0.1321
Brugia malayi hypothetical protein 0.011 0.1321 0.127
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) follicle stimulating hormone receptor 0.011 0.1321 0.127
Echinococcus multilocularis neuropeptide s receptor 0.011 0.1321 0.1321
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0785 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus multilocularis g protein coupled receptor 0.011 0.1321 0.1321
Brugia malayi putative neuropeptide receptor 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.0068 0.0711 0.0656
Loa Loa (eye worm) TYRA-2 protein 0.011 0.1321 0.127
Echinococcus granulosus orexin receptor type 2 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Brugia malayi hypothetical protein 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Loa Loa (eye worm) G-protein coupled receptor 0.011 0.1321 0.127
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0457 0.0457
Echinococcus multilocularis neuropeptides capa receptor 0.011 0.1321 0.1321
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.011 0.1321 0.1321
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.011 0.1321 0.1321
Schistosoma mansoni opsin-like receptor 0.011 0.1321 0.1321
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.011 0.1321 0.1321
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.011 0.1321 0.1321
Echinococcus granulosus tm gpcr rhodopsin 0.011 0.1321 0.1321
Brugia malayi putative neuropeptide receptor NPR1 0.011 0.1321 0.127
Schistosoma mansoni biogenic amine (dopamine) receptor 0.011 0.1321 0.1321
Echinococcus granulosus dro:myosuppressin receptor 0.011 0.1321 0.1321
Brugia malayi hypothetical protein 0.011 0.1321 0.127
Brugia malayi Tachykinin-like peptides receptor 99D 0.011 0.1321 0.127
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.011 0.1321 0.1321
Schistosoma mansoni biogenic amine (dopamine) receptor 0.011 0.1321 0.1321
Schistosoma mansoni neuropeptide f receptor 76f 0.011 0.1321 0.1321
Schistosoma mansoni glutamate receptor AMPA 0.005 0.0457 0.0457
Schistosoma mansoni biogenic amine (dopamine) receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) G-protein coupled receptor 0.011 0.1321 0.127
Echinococcus granulosus neuropeptide Y receptor 0.011 0.1321 0.1321
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.011 0.1321 0.1321
Echinococcus granulosus ceramide glucosyltransferase 0.071 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.011 0.1321 0.1321
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.006 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus granulosus glutamate NMDA receptor subunit 0.005 0.0457 0.0457
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1321 0.1321
Echinococcus multilocularis serotonin receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Chlamydia trachomatis glutamine binding protein 0.0048 0.042 0.5
Brugia malayi G-protein coupled receptor 0.011 0.1321 0.127
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0048 0.042 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.011 0.1321 0.1321
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1321 0.1321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1321 0.1321
Schistosoma mansoni neuropeptide F-like receptor 0.011 0.1321 0.1321
Echinococcus multilocularis alpha 1A adrenergic receptor 0.011 0.1321 0.1321
Schistosoma mansoni opsin-like receptor 0.011 0.1321 0.1321
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1321 0.1321
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.011 0.1321 0.1321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1321 0.1321
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.011 0.1321 0.1321
Echinococcus granulosus 7tm_1 domain containing protein 0.011 0.1321 0.1321
Schistosoma mansoni biogenic amine receptor 0.011 0.1321 0.1321
Echinococcus multilocularis somatostatin receptor 0.011 0.1321 0.1321
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0048 0.042 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus multilocularis biogenic amine (5HT) receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus granulosus somatostatin receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0261 0.0204
Brugia malayi neuropeptide F receptor 0.011 0.1321 0.127
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0261 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.011 0.1321 0.1321
Echinococcus granulosus neuropeptide receptor A26 0.011 0.1321 0.1321
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1321 0.1321
Brugia malayi G protein-coupled receptor 0.011 0.1321 0.127
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.011 0.1321 0.1321
Brugia malayi follicle stimulating hormone receptor 0.011 0.1321 0.127
Echinococcus granulosus G protein coupled receptor 139 0.011 0.1321 0.1321
Echinococcus multilocularis nmda type glutamate receptor 0.0066 0.0689 0.0689
Echinococcus multilocularis neuropeptide FF receptor 2 0.011 0.1321 0.1321
Brugia malayi hypothetical protein 0.011 0.1321 0.127
Schistosoma mansoni amine GPCR 0.011 0.1321 0.1321
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0261 1
Schistosoma mansoni neuropeptide receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0261 1
Loa Loa (eye worm) glutamate receptor 1 0.005 0.0457 0.0401
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1321 0.1321
Schistosoma mansoni glutamate receptor AMPA 0.005 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Brugia malayi Dopamine receptor 0.011 0.1321 0.127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1321 0.1321
Schistosoma mansoni myosin xvIII 0.011 0.1321 0.1321
Echinococcus granulosus sex peptide receptor 0.011 0.1321 0.1321
Echinococcus granulosus tm gpcr rhodopsin 0.011 0.1321 0.1321
Loa Loa (eye worm) glutamate receptor 2 0.005 0.0457 0.0401
Echinococcus multilocularis tachykinin peptides receptor 99D 0.011 0.1321 0.1321
Brugia malayi gonadotropin-releasing hormone receptor 2 0.011 0.1321 0.127
Schistosoma mansoni adenoreceptor 0.011 0.1321 0.1321
Brugia malayi hypothetical protein 0.011 0.1321 0.127
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Schistosoma mansoni glutamate receptor kainate 0.005 0.0457 0.0457
Echinococcus multilocularis fmrfamide receptor 0.011 0.1321 0.1321
Echinococcus granulosus biogenic amine 5HT receptor 0.011 0.1321 0.1321
Schistosoma mansoni amine GPCR 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127
Echinococcus granulosus g-protein coupled receptor 0.011 0.1321 0.1321
Schistosoma mansoni biogenic amine receptor 0.011 0.1321 0.1321
Loa Loa (eye worm) hypothetical protein 0.011 0.1321 0.127

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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