Detailed information for compound 885520

Basic information

Technical information
  • TDR Targets ID: 885520
  • Name: 4-(2-methylsulfanylphenyl)-N-(4-methylsulfany lphenyl)piperazine-1-carboxamide
  • MW: 373.535 | Formula: C19H23N3OS2
  • H donors: 1 H acceptors: 1 LogP: 3.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)NC(=O)N1CCN(CC1)c1ccccc1SC
  • InChi: 1S/C19H23N3OS2/c1-24-16-9-7-15(8-10-16)20-19(23)22-13-11-21(12-14-22)17-5-3-4-6-18(17)25-2/h3-10H,11-14H2,1-2H3,(H,20,23)
  • InChiKey: OPPOVTQELAZHBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-(methylthio)phenyl]-N-[4-(methylthio)phenyl]-1-piperazinecarboxamide
  • 4-[2-(methylthio)phenyl]-N-[4-(methylthio)phenyl]piperazine-1-carboxamide
  • Oprea1_585805

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0112 0.0856 0.0713
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0112 0.0856 0.0571
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0112 0.0856 0.0856
Brugia malayi hypothetical protein 0.0112 0.0856 0.0713
Echinococcus multilocularis dro:myosuppressin receptor 0.0112 0.0856 0.0571
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0071 0.0409 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0089 0.061 0.0318
Echinococcus granulosus tachykinin peptides receptor 99D 0.0112 0.0856 0.0571
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0099 0.0717 0.0429
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.0856 0.0571
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0112 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Brugia malayi hypothetical protein 0.0055 0.023 0.0077
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.0856 0.0423
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0937 1 1
Schistosoma mansoni opsin-like receptor 0.0112 0.0856 0.0423
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.0856 0.0423
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0071 0.0409 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Loa Loa (eye worm) melatonin receptor type 1A 0.0112 0.0856 0.0856
Echinococcus granulosus G protein coupled receptor 139 0.0112 0.0856 0.0571
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.0856 0.0423
Schistosoma mansoni hypothetical protein 0.0112 0.0856 0.0423
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Brugia malayi Glutamate receptor 1 precursor 0.0075 0.0452 0.0302
Brugia malayi AKH receptor 0.0112 0.0856 0.0713
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Schistosoma mansoni amine GPCR 0.0112 0.0856 0.0423
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.0856 0.0571
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0089 0.061 0.0318
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Schistosoma mansoni amine GPCR 0.0112 0.0856 0.0423
Schistosoma mansoni hypothetical protein 0.0112 0.0856 0.0423
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0112 0.0856 0.0423
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0089 0.061 0.0318
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0079 0.0493 0.0493
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0075 0.0452 0.0155
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0055 0.023 0.023
Brugia malayi putative neuropeptide receptor 0.0112 0.0856 0.0713
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0112 0.0856 0.0856
Echinococcus multilocularis fmrfamide receptor 0.0112 0.0856 0.0571
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0154 0.5
Echinococcus granulosus orexin receptor type 2 0.0112 0.0856 0.0571
Schistosoma mansoni adenoreceptor 0.0112 0.0856 0.0423
Echinococcus granulosus glutamate receptor 2 0.0089 0.061 0.0318
Brugia malayi hypothetical protein 0.0112 0.0856 0.0713
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0112 0.0856 0.0713
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0856 0.0423
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0154 0.0154
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.0856 0.0856
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0856 0.0423
Echinococcus multilocularis neuropeptide receptor 0.0112 0.0856 0.0571
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0112 0.0856 0.0423
Loa Loa (eye worm) integrin beta-2 0.0351 0.3513 0.3513
Schistosoma mansoni alpha-1 adrenergic receptor 0.0112 0.0856 0.0423
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Brugia malayi Integrin beta pat-3 precursor 0.0351 0.3513 0.3412
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0089 0.061 0.0318
Loa Loa (eye worm) ceramide glucosyltransferase 0.0937 1 1
Schistosoma mansoni ceramide glucosyltransferase 0.0937 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0079 0.0493 0.0344
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus granulosus 7tm_1 domain containing protein 0.0112 0.0856 0.0571
Loa Loa (eye worm) glutamate receptor 1 0.0075 0.0452 0.0452
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.0856 0.0423
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.0856 0.0856
Schistosoma mansoni ceramide glucosyltransferase 0.0937 1 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0112 0.0856 0.0571
Echinococcus multilocularis ceramide glucosyltransferase 0.0937 1 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.0856 0.0571
Echinococcus multilocularis serotonin receptor 0.0112 0.0856 0.0571
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.0856 0.0423
Echinococcus multilocularis G-protein coupled receptor, putative 0.0112 0.0856 0.0571
Brugia malayi Serotonin receptor 0.0112 0.0856 0.0713
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0856 0.0423
Echinococcus granulosus g protein coupled receptor 0.0112 0.0856 0.0571
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.0856 0.0423
Echinococcus multilocularis glutamate receptor 2 0.0089 0.061 0.0318
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0112 0.0856 0.0713
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Echinococcus multilocularis neuropeptide receptor A26 0.0112 0.0856 0.0571
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.0856 0.0423
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0112 0.0856 0.0571
Echinococcus granulosus sex peptide receptor 0.0112 0.0856 0.0571
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.0856 0.0571
Schistosoma mansoni neuropeptide receptor 0.0112 0.0856 0.0423
Echinococcus multilocularis sex peptide receptor 0.0112 0.0856 0.0571
Echinococcus multilocularis g protein coupled receptor 0.0112 0.0856 0.0571
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0112 0.0856 0.0423
Schistosoma mansoni opsin-like receptor 0.0112 0.0856 0.0423
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.0856 0.0571
Echinococcus granulosus neuropeptide receptor A26 0.0112 0.0856 0.0571
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.0856 0.0571
Echinococcus multilocularis G protein coupled receptor 139 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Brugia malayi larval opioid receptor 0.0112 0.0856 0.0713
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus multilocularis g protein coupled receptor 0.0112 0.0856 0.0571
Echinococcus multilocularis orexin receptor type 2 0.0112 0.0856 0.0571
Brugia malayi putative neuropeptide receptor NPR1 0.0112 0.0856 0.0713
Schistosoma mansoni voltage-gated potassium channel 0.0086 0.0573 0.0127
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0112 0.0856 0.0571
Trypanosoma brucei cytochrome P450, putative 0.0048 0.0154 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Schistosoma mansoni hypothetical protein 0.0112 0.0856 0.0423
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0079 0.0493 0.0197
Schistosoma mansoni neuropeptide receptor 0.0112 0.0856 0.0423
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0112 0.0856 0.0856
Echinococcus multilocularis neuropeptide receptor 0.0112 0.0856 0.0571
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.0856 0.0571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0856 0.0423
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Schistosoma mansoni hypothetical protein 0.0112 0.0856 0.0423
Echinococcus granulosus g-protein coupled receptor 0.0112 0.0856 0.0571
Giardia lamblia Ceramide glucosyltransferase 0.0425 0.4325 0.5
Echinococcus granulosus fmrfamide receptor 0.0112 0.0856 0.0571
Echinococcus granulosus allatostatin A receptor 0.0112 0.0856 0.0571
Brugia malayi ORL1-like opioid receptor 0.0112 0.0856 0.0713
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.0856 0.0571
Chlamydia trachomatis glutamine binding protein 0.0071 0.0409 0.5
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0112 0.0856 0.0423
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Brugia malayi Tachykinin-like peptides receptor 99D 0.0112 0.0856 0.0713
Schistosoma mansoni amine GPCR 0.0112 0.0856 0.0423
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus multilocularis allatostatin A receptor 0.0112 0.0856 0.0571
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0089 0.061 0.0318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0856 0.0423
Brugia malayi G protein-coupled receptor F59B2.13 0.0112 0.0856 0.0713
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Loa Loa (eye worm) CYP4Cod1 0.0048 0.0154 0.0154
Echinococcus granulosus g protein coupled receptor 0.0112 0.0856 0.0571
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0112 0.0856 0.0571
Brugia malayi Dopamine receptor protein 2 0.0112 0.0856 0.0713
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Loa Loa (eye worm) TYRA-2 protein 0.0112 0.0856 0.0856
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0112 0.0856 0.0571
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0071 0.0409 0.5
Echinococcus multilocularis somatostatin receptor 0.0112 0.0856 0.0571
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.0856 0.0571
Schistosoma mansoni opsin-like receptor 0.0112 0.0856 0.0423
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Schistosoma mansoni amine GPCR 0.0112 0.0856 0.0423
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0112 0.0856 0.0571
Schistosoma mansoni biogenic amine receptor 0.0112 0.0856 0.0423
Brugia malayi sulfakinin receptor protein 0.0112 0.0856 0.0713
Echinococcus granulosus g protein coupled receptor 0.0112 0.0856 0.0571
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.0856 0.0571
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Echinococcus granulosus 7TM GPCR rhodopsin 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus multilocularis serotonin receptor 0.0112 0.0856 0.0571
Schistosoma mansoni neuropeptide receptor 0.0112 0.0856 0.0423
Brugia malayi G-protein coupled receptor 0.0112 0.0856 0.0713
Loa Loa (eye worm) hypothetical protein 0.0068 0.0377 0.0377
Brugia malayi Kelch motif family protein 0.0055 0.023 0.0077
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0089 0.061 0.0318
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0112 0.0856 0.0423
Echinococcus granulosus ceramide glucosyltransferase 0.0937 1 1
Echinococcus granulosus serotonin receptor 0.0112 0.0856 0.0571
Brugia malayi Glutamate receptor 2 precursor 0.0075 0.0452 0.0302
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Schistosoma mansoni histamine h1 receptor 0.0112 0.0856 0.0423
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0071 0.0409 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.0856 0.0571
Echinococcus granulosus alpha 1A adrenergic receptor 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0112 0.0856 0.0423
Echinococcus granulosus dro:myosuppressin receptor 0.0112 0.0856 0.0571
Echinococcus multilocularis integrin beta 2 0.0257 0.247 0.2236
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0856 0.0423
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus granulosus glutamate NMDA receptor subunit 0.0075 0.0452 0.0155
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus granulosus neuropeptide FF receptor 2 0.0112 0.0856 0.0571
Echinococcus multilocularis fmrfamide receptor 0.0112 0.0856 0.0571
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.0856 0.0423
Brugia malayi hypothetical protein 0.0112 0.0856 0.0713
Brugia malayi hypothetical protein 0.0112 0.0856 0.0713
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Schistosoma mansoni biogenic amine receptor 0.0112 0.0856 0.0423
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0856 0.0423
Brugia malayi GnHR receptor homolog 0.0112 0.0856 0.0713
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0112 0.0856 0.0571
Echinococcus multilocularis glutamate receptor 2 0.0075 0.0452 0.0155
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0074 0.0435 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0112 0.0856 0.0571
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0074 0.0435 0.5
Leishmania major cytochrome p450-like protein 0.0048 0.0154 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0154 0.5
Brugia malayi hypothetical protein 0.0112 0.0856 0.0713
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Schistosoma mansoni biogenic amine receptor 0.0112 0.0856 0.0423
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Brugia malayi hypothetical protein 0.0112 0.0856 0.0713
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.0856 0.0571
Echinococcus multilocularis neuropeptide FF receptor 2 0.0112 0.0856 0.0571
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0089 0.061 0.0318
Brugia malayi hypothetical protein 0.0112 0.0856 0.0713
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus granulosus nmda type glutamate receptor 0.0099 0.0717 0.0429
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0112 0.0856 0.0713
Brugia malayi G-protein coupled receptor 0.0112 0.0856 0.0713
Echinococcus granulosus neuropeptide s receptor 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0055 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Brugia malayi Dopamine receptor protein 1 0.0112 0.0856 0.0713
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0112 0.0856 0.0713
Brugia malayi neuropeptide F receptor 0.0112 0.0856 0.0713
Schistosoma mansoni integrin beta subunit 0.0202 0.1859 0.1473
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0112 0.0856 0.0856
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0089 0.061 0.0318
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Echinococcus multilocularis g-protein coupled receptor 0.0112 0.0856 0.0571
Brugia malayi G protein-coupled receptor 0.0112 0.0856 0.0713
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Brugia malayi hypothetical protein 0.0112 0.0856 0.0713
Brugia malayi Melatonin receptor type 1A 0.0112 0.0856 0.0713
Echinococcus granulosus hypothetical protein 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0071 0.0409 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.0856 0.0856
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0154 0.0154
Brugia malayi Serotonin receptor 0.0112 0.0856 0.0713
Schistosoma mansoni neuropeptide f receptor 76f 0.0112 0.0856 0.0423
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Brugia malayi follicle stimulating hormone receptor 0.0112 0.0856 0.0713
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Echinococcus granulosus integrin beta 2 0.0257 0.247 0.2236
Schistosoma mansoni voltage-gated potassium channel 0.0086 0.0573 0.0127
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0112 0.0856 0.0423
Schistosoma mansoni neuropeptide receptor 0.0112 0.0856 0.0423
Schistosoma mansoni myosin xvIII 0.0112 0.0856 0.0423
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0112 0.0856 0.0571
Brugia malayi Dopamine receptor 0.0112 0.0856 0.0713
Schistosoma mansoni growth hormone secretagogue receptor 0.0112 0.0856 0.0423
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0112 0.0856 0.0423
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.0856 0.0571
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0112 0.0856 0.0571
Echinococcus granulosus neuropeptide receptor 0.0112 0.0856 0.0571
Brugia malayi hypothetical protein 0.0112 0.0856 0.0713
Echinococcus granulosus peptide allatostatin:somatostatin 0.0112 0.0856 0.0571
Schistosoma mansoni amine GPCR 0.0112 0.0856 0.0423
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0112 0.0856 0.0571
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.0856 0.0571
Loa Loa (eye worm) glutamate receptor 2 0.0075 0.0452 0.0452
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0856 0.0423
Echinococcus granulosus somatostatin receptor 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.0856 0.0856
Echinococcus granulosus neuropeptide receptor 0.0112 0.0856 0.0571
Brugia malayi RE15519p 0.0112 0.0856 0.0713
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0856 0.0571
Brugia malayi neuropeptide F receptor 0.0112 0.0856 0.0713
Schistosoma mansoni glutamate receptor NMDA 0.0089 0.061 0.0166
Echinococcus multilocularis g protein coupled receptor 0.0112 0.0856 0.0571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0856 0.0423
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.0856 0.0571
Echinococcus multilocularis nmda type glutamate receptor 0.0099 0.0717 0.0429
Echinococcus multilocularis neuropeptide s receptor 0.0112 0.0856 0.0571
Loa Loa (eye worm) hypothetical protein 0.0112 0.0856 0.0856
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.0856 0.0423
Brugia malayi hypothetical protein 0.0112 0.0856 0.0713
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0079 0.0493 0.0197

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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