TDR Targets

Basic information

Technical information

TDR Targets ID: 885528
Name: 1-[8-(3-thiophen-3-ylprop-2-enoyl)-3,8-diazas piro[4.5]decan-3-yl]hex-2-yn-1-one
MW: 370.508 | Formula: C21H26N2O2S
H donors: 0 H acceptors: 2 LogP: 3.69 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCCC#CC(=O)N1CCC2(C1)CCN(CC2)C(=O)C=Cc1ccsc1
InChi: 1S/C21H26N2O2S/c1-2-3-4-5-19(24)23-14-11-21(17-23)9-12-22(13-10-21)20(25)7-6-18-8-15-26-16-18/h6-8,15-16H,2-3,9-14,17H2,1H3/b7-6+
InChiKey: FEAFGKCUJKQQQM-VOTSOKGWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[8-[3-(3-thienyl)prop-2-enoyl]-3,8-diazaspiro[4.5]decan-3-yl]hex-2-yn-1-one
1-[8-[1-oxo-3-(3-thienyl)prop-2-enyl]-3,8-diazaspiro[4.5]decan-3-yl]hex-2-yn-1-one
1-[8-[3-(3-thienyl)acryloyl]-3,8-diazaspiro[4.5]decan-3-yl]hex-2-yn-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	dro:myosuppressin receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus multilocularis	ceramide glucosyltransferase	0.0949	1	1
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0109	0.0976	0.0976
Echinococcus granulosus	fmrfamide receptor	0.0109	0.0976	0.0976
Echinococcus multilocularis	g protein coupled receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	ceramide glucosyltransferase	0.0949	1	1
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus granulosus	biogenic amine 5HT receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0079	0.0649	0.0649
Echinococcus multilocularis	neuropeptides capa receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	voltage-gated potassium channel	0.0086	0.0727	0.0727
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0109	0.0976	0.0976
Leishmania major	cytochrome p450-like protein	0.0049	0.0326	1
Loa Loa (eye worm)	glutamate receptor 1	0.005	0.034	0.0295
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.006	0.0442	0.0442
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0109	0.0976	0.0976
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.0949	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0464	0.0464
Schistosoma mansoni	ceramide glucosyltransferase	0.0949	1	1
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus granulosus	nmda type glutamate receptor	0.0066	0.0512	0.0512
Echinococcus granulosus	7tm_1 domain containing protein	0.0109	0.0976	0.0976
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0023	0.0046	0.0046
Loa Loa (eye worm)	cytochrome P450 family protein	0.0049	0.0326	0.0281
Schistosoma mansoni	glutamate receptor AMPA	0.005	0.034	0.034
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Brugia malayi	AKH receptor	0.0109	0.0976	0.0934
Schistosoma mansoni	glutamate receptor kainate	0.005	0.034	0.034
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.006	0.0442	0.0442
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0464	0.042
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0109	0.0976	0.0976
Brugia malayi	larval opioid receptor	0.0109	0.0976	0.0934
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0464	0.042
Brugia malayi	GnHR receptor homolog	0.0109	0.0976	0.0934
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0079	0.0649	0.0605
Echinococcus granulosus	voltage gated potassium channel	0.0023	0.0046	0.0046
Schistosoma mansoni	myosin xvIII	0.0109	0.0976	0.0976
Schistosoma mansoni	neuropeptide receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	G-protein coupled receptor	0.0109	0.0976	0.0934
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0464	0.0464
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0464	0.0464
Schistosoma mansoni	neuropeptide receptor	0.0109	0.0976	0.0976
Echinococcus multilocularis	neuropeptide receptor A26	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	biogenic amine 5HT receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	neuropeptide receptor	0.0109	0.0976	0.0976
Trypanosoma cruzi	cytochrome P450, putative	0.0049	0.0326	1
Echinococcus granulosus	g protein coupled receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	somatostatin receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Echinococcus multilocularis	glutamate receptor 2	0.006	0.0442	0.0442
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0109	0.0976	0.0934
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0109	0.0976	0.0976
Brugia malayi	putative neuropeptide receptor NPR1	0.0109	0.0976	0.0934
Schistosoma mansoni	amine GPCR	0.0109	0.0976	0.0976
Echinococcus granulosus	orexin receptor type 2	0.0109	0.0976	0.0976
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.006	0.0442	0.0442
Echinococcus granulosus	hypothetical protein	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0109	0.0976	0.0934
Schistosoma mansoni	biogenic amine receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	voltage-gated potassium channel	0.0086	0.0727	0.0727
Echinococcus granulosus	ceramide glucosyltransferase	0.0949	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0109	0.0976	0.0976
Brugia malayi	Glutamate receptor 1 precursor	0.005	0.034	0.0295
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0464	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus granulosus	glutamate NMDA receptor subunit	0.005	0.034	0.034
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0074	0.0593	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0109	0.0976	0.0976
Brugia malayi	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus multilocularis	sex peptide receptor	0.0109	0.0976	0.0976
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0023	0.0044	0.5
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Brugia malayi	putative neuropeptide receptor	0.0109	0.0976	0.0934
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0109	0.0976	0.0976
Brugia malayi	G-protein coupled receptor	0.0109	0.0976	0.0934
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0109	0.0976	0.0976
Echinococcus multilocularis	nmda type glutamate receptor	0.0066	0.0512	0.0512
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0109	0.0976	0.0976
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0109	0.0976	0.0976
Brugia malayi	Dopamine receptor protein 1	0.0109	0.0976	0.0934
Echinococcus multilocularis	fmrfamide receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	glutamate receptor kainate	0.005	0.034	0.034
Schistosoma mansoni	neuropeptide F-like receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0109	0.0976	0.0976
Echinococcus multilocularis	voltage gated potassium channel	0.0023	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus granulosus	neuropeptide receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Brugia malayi	RNA binding protein	0.0062	0.0464	0.042
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0109	0.0976	0.0976
Echinococcus granulosus	tm gpcr rhodopsin	0.0109	0.0976	0.0976
Brugia malayi	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus granulosus	sex peptide receptor	0.0109	0.0976	0.0976
Giardia lamblia	Ceramide glucosyltransferase	0.043	0.4424	0.5
Echinococcus granulosus	neuropeptide receptor	0.0109	0.0976	0.0976
Brugia malayi	hypothetical protein	0.0109	0.0976	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0109	0.0976	0.0976
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0048	0.0312	0.9498
Echinococcus multilocularis	neuropeptide receptor	0.0109	0.0976	0.0976
Echinococcus multilocularis	g protein coupled receptor	0.0109	0.0976	0.0976
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.005	0.034	0.034
Echinococcus granulosus	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0464	0.0464
Echinococcus multilocularis	G protein coupled receptor 139	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus granulosus	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus granulosus	neuropeptide FF receptor 2	0.0109	0.0976	0.0976
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0109	0.0976	0.0976
Brugia malayi	Serotonin receptor	0.0109	0.0976	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus multilocularis	dro:myosuppressin receptor	0.0109	0.0976	0.0976
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0049	0.0326	1
Brugia malayi	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	amine GPCR	0.0109	0.0976	0.0976
Echinococcus multilocularis	g protein coupled receptor	0.0109	0.0976	0.0976
Echinococcus multilocularis	neuropeptide Y receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0079	0.0649	0.0649
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0109	0.0976	0.0976
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0048	0.0312	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0109	0.0976	0.0976
Echinococcus granulosus	7TM GPCR rhodopsin	0.0109	0.0976	0.0976
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0109	0.0976	0.0976
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0048	0.0312	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0109	0.0976	0.0976
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0023	0.0046	0.0046
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0109	0.0976	0.0934
Schistosoma mansoni	histamine h1 receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0464	0.0464
Schistosoma mansoni	amine GPCR	0.0109	0.0976	0.0976
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0109	0.0976	0.0976
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0066	0.0512	0.0512
Echinococcus multilocularis	serotonin receptor	0.0109	0.0976	0.0976
Echinococcus multilocularis	neuropeptides capa receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	hypothetical protein	0.0109	0.0976	0.0976
Echinococcus granulosus	G protein coupled receptor 139	0.0109	0.0976	0.0976
Echinococcus granulosus	neuropeptide receptor A26	0.0109	0.0976	0.0976
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0109	0.0976	0.0976
Brugia malayi	follicle stimulating hormone receptor	0.0109	0.0976	0.0934
Echinococcus multilocularis	glutamate receptor 2	0.005	0.034	0.034
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.006	0.0442	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	glutamate receptor NMDA	0.006	0.0442	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Brugia malayi	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	neuropeptide f receptor 76f	0.0109	0.0976	0.0976
Schistosoma mansoni	amine GPCR	0.0109	0.0976	0.0976
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0048	0.0312	0.5
Brugia malayi	Glutamate receptor 2 precursor	0.005	0.034	0.0295
Brugia malayi	ORL1-like opioid receptor	0.0109	0.0976	0.0934
Brugia malayi	neuropeptide F receptor	0.0109	0.0976	0.0934
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0109	0.0976	0.0976
Echinococcus multilocularis	orexin receptor type 2	0.0109	0.0976	0.0976
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.006	0.0442	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Brugia malayi	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	hypothetical protein	0.0109	0.0976	0.0976
Schistosoma mansoni	biogenic amine receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Echinococcus granulosus	serotonin receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0109	0.0976	0.0934
Loa Loa (eye worm)	neuropeptide F receptor	0.0109	0.0976	0.0934
Schistosoma mansoni	voltage-gated potassium channel	0.0023	0.0046	0.0046
Echinococcus multilocularis	allatostatin A receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.006	0.0442	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0175	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.006	0.0442	0.0442
Schistosoma mansoni	opsin-like receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	ceramide glucosyltransferase	0.0949	1	1
Schistosoma mansoni	amine GPCR	0.0109	0.0976	0.0976
Brugia malayi	TAR-binding protein	0.0062	0.0464	0.042
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus granulosus	tm gpcr rhodopsin	0.0109	0.0976	0.0976
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0109	0.0976	0.0976
Schistosoma mansoni	glutamate receptor AMPA	0.005	0.034	0.034
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	neuropeptide s receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Echinococcus granulosus	glutamate receptor 2	0.0041	0.0243	0.0243
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0109	0.0976	0.0934
Schistosoma mansoni	ATP-binding cassette transporter	0.005	0.034	0.034
Schistosoma mansoni	glutamate receptor NMDA	0.005	0.034	0.034
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0109	0.0976	0.0976
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0109	0.0976	0.0976
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Loa Loa (eye worm)	glutamate receptor 2	0.005	0.034	0.0295
Echinococcus multilocularis	serotonin receptor	0.0109	0.0976	0.0976
Brugia malayi	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	neuropeptide receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	hypothetical protein	0.0109	0.0976	0.0976
Echinococcus granulosus	tm gpcr rhodopsin	0.0109	0.0976	0.0976
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0109	0.0976	0.0976
Brugia malayi	Dopamine receptor	0.0109	0.0976	0.0934
Brugia malayi	Cytochrome P450 family protein	0.0049	0.0326	0.0281
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0109	0.0976	0.0976
Echinococcus granulosus	neuropeptide Y receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	cytochrome P450 family protein	0.0049	0.0326	0.0281
Schistosoma mansoni	voltage-gated potassium channel	0.0023	0.0046	0.0046
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	TYRA-2 protein	0.0109	0.0976	0.0934
Schistosoma mansoni	adenoreceptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus multilocularis	neuropeptide Y receptor	0.0109	0.0976	0.0976
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0074	0.0593	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	g protein coupled receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0464	0.0464
Brugia malayi	RE15519p	0.0109	0.0976	0.0934
Brugia malayi	Melatonin receptor type 1A	0.0109	0.0976	0.0934
Brugia malayi	sulfakinin receptor protein	0.0109	0.0976	0.0934
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0109	0.0976	0.0934
Chlamydia trachomatis	glutamine binding protein	0.0048	0.0312	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0109	0.0976	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus granulosus	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Echinococcus multilocularis	neuropeptide receptor	0.0109	0.0976	0.0976
Brugia malayi	hypothetical protein	0.0109	0.0976	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0537	0.0493
Echinococcus granulosus	neuropeptides capa receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	hypothetical protein	0.0109	0.0976	0.0976
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0109	0.0976	0.0976
Brugia malayi	Dopamine receptor protein 2	0.0109	0.0976	0.0934
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0109	0.0976	0.0976
Echinococcus granulosus	neuropeptides capa receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	g protein coupled receptor	0.0109	0.0976	0.0976
Brugia malayi	Serotonin receptor	0.0109	0.0976	0.0934
Schistosoma mansoni	growth hormone secretagogue receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	glutamate receptor 2	0.006	0.0442	0.0442
Echinococcus multilocularis	g-protein coupled receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	opsin-like receptor	0.0109	0.0976	0.0976
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Schistosoma mansoni	neuropeptide F-like receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0109	0.0976	0.0976
Brugia malayi	G protein-coupled receptor	0.0109	0.0976	0.0934
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	opsin-like receptor	0.0109	0.0976	0.0976
Trypanosoma brucei	cytochrome P450, putative	0.0049	0.0326	0.5
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus multilocularis	somatostatin receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0109	0.0976	0.0976
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0464	0.042
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0109	0.0976	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus granulosus	allatostatin A receptor	0.0109	0.0976	0.0976
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0109	0.0976	0.0976
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0048	0.0312	1
Brugia malayi	hypothetical protein	0.0109	0.0976	0.0934
Echinococcus multilocularis	fmrfamide receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	neuropeptide F receptor	0.0109	0.0976	0.0934
Brugia malayi	G protein-coupled receptor F59B2.13	0.0109	0.0976	0.0934
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.006	0.0442	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0464	0.042
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0109	0.0976	0.0934
Brugia malayi	neuropeptide F receptor	0.0109	0.0976	0.0934
Echinococcus multilocularis	glutamate receptor 2	0.0041	0.0243	0.0243
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0109	0.0976	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Loa Loa (eye worm)	CYP4Cod1	0.0049	0.0326	0.0281
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0109	0.0976	0.0976
Loa Loa (eye worm)	melatonin receptor type 1A	0.0109	0.0976	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0976	0.0934
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0109	0.0976	0.0934
Schistosoma mansoni	glutamate receptor kainate	0.005	0.034	0.034
Trypanosoma cruzi	cytochrome P450, putative	0.0049	0.0326	1
Brugia malayi	G-protein coupled receptor	0.0109	0.0976	0.0934
Schistosoma mansoni	biogenic amine receptor	0.0109	0.0976	0.0976
Brugia malayi	hypothetical protein	0.0109	0.0976	0.0934
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0079	0.0649	0.0605
Brugia malayi	Cytochrome P450 family protein	0.0049	0.0326	0.0281
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0109	0.0976	0.0934
Loa Loa (eye worm)	G-protein coupled receptor	0.0109	0.0976	0.0934

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 885528