Detailed information for compound 885875

Basic information

Technical information
  • TDR Targets ID: 885875
  • Name: 5-chloro-2-methoxy-N-quinolin-3-ylbenzenesulf onamide
  • MW: 348.804 | Formula: C16H13ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1S(=O)(=O)Nc1cnc2c(c1)cccc2)Cl
  • InChi: 1S/C16H13ClN2O3S/c1-22-15-7-6-12(17)9-16(15)23(20,21)19-13-8-11-4-2-3-5-14(11)18-10-13/h2-10,19H,1H3
  • InChiKey: YVBIXROGJRXBAE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-2-methoxy-N-(3-quinolyl)benzenesulfonamide
  • 5-chloro-2-methoxy-N-quinolin-3-yl-benzenesulfonamide
  • MLS-0202007.0001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens alkaline phosphatase, liver/bone/kidney Starlite/ChEMBL No references
Homo sapiens glyceraldehyde-3-phosphate dehydrogenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 Get druggable targets OG5_126628 All targets in OG5_126628
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum ko:K00134 glyceraldehyde 3-phosphate dehydrogenase [EC1.2.1.12], putative Get druggable targets OG5_126628 All targets in OG5_126628
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania braziliensis glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum Alkaline phosphatase, tissue-nonspecific isozyme precursor, putative Get druggable targets OG5_126976 All targets in OG5_126976
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Cryptosporidium parvum glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Plasmodium yoelii glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum ko:K01077 alkaline phosphatase [EC3.1.3.1], putative Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium knowlesi glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Cryptosporidium hominis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus alkaline phosphatase intestinal gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Babesia bovis glyceraldehyde-3-phosphate dehydrogenase protein Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12), related Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium berghei glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative glyceraldehyde-3-phosphate dehydrogenase 293 aa 259 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0344 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.2751 0.5
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0344 0.0342
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.2751 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0344 0.1249
Schistosoma mansoni alkaline phosphatase 0.0196 0.8619 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0344 0.0342
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.2751 0.2909
Brugia malayi beta-lactamase family protein 0.0035 0.0344 0.0566
Loa Loa (eye worm) RNA binding protein 0.0061 0.1704 0.2375
Echinococcus granulosus geminin 0.0165 0.6985 0.8025
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0082 0.2751 0.5
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.1303 0.1675
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0082 0.2751 0.5
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0057 0.145 0.1932
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0196 0.8619 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0054 0.1303 0.116
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0054 0.1303 0.4737
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0196 0.8619 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.2751 1
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0082 0.2751 0.5
Schistosoma mansoni hypothetical protein 0.0165 0.6985 0.8025
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2751 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.2751 1
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0082 0.2751 1
Echinococcus granulosus alkaline phosphatase 0.0196 0.8619 1
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1301 0.3976
Schistosoma mansoni alkaline phosphatase 0.0196 0.8619 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0344 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.1303 0.1675
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.2751 0.2909
Loa Loa (eye worm) hypothetical protein 0.0054 0.1303 0.1675
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0196 0.8619 1
Echinococcus multilocularis alkaline phosphatase 0.0196 0.8619 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2751 1
Brugia malayi beta-lactamase 0.0035 0.0344 0.0566
Mycobacterium tuberculosis Conserved protein 0.0035 0.0344 0.0342
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.2751 0.2909
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.2751 0.5
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0054 0.1303 0.116
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1704 0.2375
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1704 0.1644
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0082 0.2751 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1704 0.2375
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2751 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0344 0.1249
Schistosoma mansoni hypothetical protein 0.0102 0.3783 0.4156
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1704 0.1644
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.2751 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0344 0.1249
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2751 1
Brugia malayi hypothetical protein 0.0147 0.6072 1
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0082 0.2751 0.5
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0057 0.145 0.1932
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.2751 0.4531
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1704 0.1644
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.2751 0.2909
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.2751 0.2909
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1301 0.3976
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2751 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0082 0.2751 1
Brugia malayi RNA binding protein 0.0061 0.1704 0.2807
Echinococcus granulosus tar DNA binding protein 0.0061 0.1704 0.1644
Schistosoma mansoni hypothetical protein 0.0165 0.6985 0.8025
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0344 0.0342
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.2751 0.2909
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1704 0.1644
Echinococcus granulosus intestinal type alkaline phosphatase 0.0196 0.8619 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.2751 0.5
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.2751 1
Trichomonas vaginalis esterase, putative 0.0035 0.0344 0.1249
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0054 0.1301 0.3976
Mycobacterium tuberculosis Conserved protein 0.0035 0.0344 0.0342
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0196 0.8619 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.6072 1
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0054 0.1301 0.3976
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0344 0.1249
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1704 0.2807
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0344 0.0566
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.2751 0.2909
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2751 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1704 0.1644
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2751 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0344 0.0342
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.2751 0.2909
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0344 0.1249
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2751 1
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.2751 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0344 0.0342
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.2751 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0344 0.0342
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0082 0.2751 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0344 0.0342
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0344 0.0342
Onchocerca volvulus 0.0147 0.6072 1
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0196 0.8619 1
Echinococcus multilocularis geminin 0.0165 0.6985 0.8025
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.2751 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0054 0.1303 0.4737
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.2751 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.2751 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1704 0.1644
Brugia malayi TAR-binding protein 0.0061 0.1704 0.2807
Brugia malayi beta-lactamase family protein 0.0035 0.0344 0.0566

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.85 uM PUBCHEM_BIOASSAY: SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1548, AID1574, AID1577, AID1659, AID518] ChEMBL. No reference
IC50 (binding) > 10 um PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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