Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.1191 | 0.0075 | 0.0145 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.6138 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2003 | 0.1704 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.2003 | 0.1704 | 0.3299 |
Schistosoma mansoni | tyrosine kinase | 0.1982 | 0.1662 | 0.3117 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.2003 | 0.1704 | 0.32 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.6138 | 1 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.3729 | 0.5165 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.6138 | 1 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.1191 | 0.0075 | 0.0145 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.6138 | 1 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.6138 | 1 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.3729 | 0.5165 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1982 | 0.1662 | 0.3117 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.3729 | 0.5165 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.6138 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.6138 | 1 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.3729 | 0.5165 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2003 | 0.1704 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.1982 | 0.1662 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.3729 | 0.5165 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.2003 | 0.1704 | 0.32 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.