Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0073 | 0.0101 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.002 | 0.0523 | 1 |
Echinococcus granulosus | calpain | 0.002 | 0.0523 | 0.0726 |
Echinococcus multilocularis | calpain | 0.002 | 0.0523 | 0.0726 |
Echinococcus multilocularis | calpain 5 | 0.002 | 0.0523 | 0.0726 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0073 | 0.0101 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0073 | 0.0101 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.5698 | 0.7898 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0073 | 0.0101 |
Echinococcus granulosus | calpain 7 C02 family | 0.002 | 0.0523 | 0.0726 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0232 | 1 | 1 |
Leishmania major | calpain, putative,cysteine peptidase, Clan CA, family C2, putative | 0.002 | 0.0523 | 0.1303 |
Brugia malayi | calpain family protein 1 | 0.0053 | 0.2013 | 0.1954 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.2334 | 0.3236 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0053 | 0.2012 | 0.1953 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.2334 | 1 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.002 | 0.0523 | 1 |
Schistosoma mansoni | calpain (C02 family) | 0.002 | 0.0523 | 0.0726 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.2334 | 1 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0039 | 0.1382 | 0.1916 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.2334 | 0.3236 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0045 | 0.1643 | 0.1581 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0053 | 0.2013 | 0.279 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0462 | 0.064 |
Plasmodium vivax | calpain, putative | 0.002 | 0.0523 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0073 | 0.0101 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0057 | 0.2184 | 0.9358 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0073 | 0.0101 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.002 | 0.0523 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0462 | 0.064 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0073 | 0.0101 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0056 | 0.2121 | 0.294 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.002 | 0.0523 | 0.0726 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.002 | 0.0523 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0073 | 0.0101 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0073 | 0.0101 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0073 | 0.0101 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0073 | 0.0101 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0462 | 0.064 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0126 | 0.5246 | 0.7272 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2334 | 1 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.7215 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.5698 | 0.7898 |
Trypanosoma brucei | antigen, putative | 0.002 | 0.0523 | 1 |
Echinococcus multilocularis | geminin | 0.017 | 0.7215 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0073 | 0.0101 |
Echinococcus granulosus | calpain 5 | 0.002 | 0.0523 | 0.0726 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.002 | 0.0523 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0057 | 0.2184 | 0.3028 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0056 | 0.2121 | 0.294 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0462 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0057 | 0.2184 | 0.3028 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.7215 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1742 | 0.1681 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0056 | 0.2121 | 0.294 |
Echinococcus granulosus | geminin | 0.017 | 0.7215 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0045 | 0.1643 | 0.1581 |
Trypanosoma brucei | calpain-like protein, putative | 0.002 | 0.0523 | 1 |
Trypanosoma brucei | calpain-like protein, putative | 0.002 | 0.0523 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0462 | 0.1005 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0073 | 0.0101 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0057 | 0.2184 | 0.9358 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.5246 | 0.7272 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.2334 | 0.3236 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.2334 | 0.3236 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0462 | 0.0392 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0073 | 0.0101 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.002 | 0.0523 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1382 | 0.1319 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0073 | 0.0101 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0073 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1111 | 0.1046 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0057 | 0.2184 | 0.3028 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0462 | 1 |
Loa Loa (eye worm) | POT family protein | 0.0124 | 0.5188 | 0.5153 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0073 | 0.0101 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0053 | 0.2013 | 0.1954 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0462 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0073 | 0.0101 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.002 | 0.0523 | 0.1303 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2013 | 0.1954 |
Brugia malayi | calpain 5 | 0.0014 | 0.0252 | 0.0181 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0073 | 0.0101 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.002 | 0.0523 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.002 | 0.0523 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.002 | 0.0523 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0057 | 0.2184 | 0.9358 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0073 | 0.0101 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0462 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0073 | 0.0101 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0126 | 0.5246 | 0.7272 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0073 | 0.0101 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.002 | 0.0523 | 1 |
Echinococcus multilocularis | calpain 7 (C02 family) | 0.002 | 0.0523 | 0.0726 |
Loa Loa (eye worm) | calpain 5 | 0.0014 | 0.0252 | 0.0181 |
Schistosoma mansoni | calpain C (C02 family) | 0.002 | 0.0523 | 0.0726 |
Brugia malayi | POT family protein | 0.0124 | 0.5188 | 0.5153 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0462 | 0.7718 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0462 | 1 |
Loa Loa (eye worm) | calpain | 0.002 | 0.0523 | 0.0454 |
Leishmania major | hypothetical protein, conserved | 0.0014 | 0.026 | 0.0038 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0056 | 0.2121 | 0.294 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.2184 | 0.2127 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.2334 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0462 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0462 | 0.064 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0073 | 0.0101 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2334 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0073 | 0.0101 |
Onchocerca volvulus | 0.0033 | 0.1111 | 1 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0073 | 0.0101 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0014 | 0.026 | 0.0294 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0057 | 0.2184 | 0.928 |
Echinococcus multilocularis | hypothetical protein | 0.002 | 0.0523 | 0.0726 |
Schistosoma mansoni | Mername-AA248 (C02 family) | 0.002 | 0.0523 | 0.0726 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.002 | 0.0523 | 0.1303 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0073 | 0.0101 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0073 | 0.0101 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0462 | 0.1977 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | calpain-7 (C02 family) | 0.002 | 0.0523 | 0.0726 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0462 | 0.5 |
Echinococcus granulosus | calpain A | 0.0056 | 0.2121 | 0.294 |
Trypanosoma brucei | calpain-like protein, putative | 0.002 | 0.0523 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0462 | 0.7718 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0462 | 0.0392 |
Brugia malayi | calpain 7 | 0.002 | 0.0523 | 0.0454 |
Brugia malayi | calpain family protein 1 | 0.0053 | 0.2013 | 0.1954 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.002 | 0.0523 | 1 |
Echinococcus multilocularis | calpain A | 0.0056 | 0.2121 | 0.294 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0014 | 0.026 | 0.0294 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0073 | 0.0101 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0039 | 0.1382 | 0.1319 |
Echinococcus granulosus | calpain A | 0.002 | 0.0523 | 0.0726 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.002 | 0.0523 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0462 | 0.7718 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.2334 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0136 | 0.5698 | 0.7898 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0462 | 0.1977 |
Trypanosoma brucei | calpain-like protein, putative | 0.002 | 0.0523 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.