Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0275 | 0.1436 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0046 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome c type-1 | 0.0099 | 0.033 | 0.2296 |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 0.1436 | 0.1998 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0184 | 0.0864 | 0.6017 |
Echinococcus multilocularis | serotonin receptor | 0.008 | 0.021 | 0.1465 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c2 | 0.0099 | 0.033 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0275 | 0.1436 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.119 | 0.7189 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0864 | 0.6017 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0447 | 0.2519 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0275 | 0.1436 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0447 | 0.2519 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0447 | 0.2519 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0447 | 0.2519 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0447 | 0.2519 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0046 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0447 | 0.2519 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0046 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0184 | 0.0864 | 0.1202 |
Onchocerca volvulus | 0.0071 | 0.0153 | 0.0153 | |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.021 | 0.1465 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.008 | 0.021 | 0.1465 |
Echinococcus granulosus | acetylcholinesterase | 0.0275 | 0.1436 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1436 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0275 | 0.1436 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.1436 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0046 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.0864 | 0.6017 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0071 | 0.0153 | 0.0213 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0275 | 0.1436 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0071 | 0.0153 | 0.1064 |
Echinococcus granulosus | acetylcholinesterase | 0.0275 | 0.1436 | 1 |
Schistosoma mansoni | amine GPCR | 0.0205 | 0.0998 | 0.6946 |
Echinococcus multilocularis | acetylcholinesterase | 0.0275 | 0.1436 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0046 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0275 | 0.1436 | 1 |
Schistosoma mansoni | cytochrome c | 0.0099 | 0.033 | 0.2296 |
Echinococcus multilocularis | serotonin receptor | 0.008 | 0.021 | 0.1465 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.021 | 0.1465 |
Echinococcus granulosus | cytochrome c | 0.0099 | 0.033 | 0.2296 |
Brugia malayi | Carboxylesterase family protein | 0.0275 | 0.1436 | 0.1998 |
Echinococcus multilocularis | cytochrome c | 0.0099 | 0.033 | 0.2296 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0447 | 0.2519 | 1 |
Brugia malayi | Cytochrome c type-1 | 0.0099 | 0.033 | 0.0459 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0046 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0153 | 0.1064 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.008 | 0.021 | 0.1465 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0447 | 0.2519 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.