Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.4558 | 0.4558 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0131 | 0 | 0.5 |
Schistosoma mansoni | tyrosine/tryptophan monooxygenase | 0.0159 | 0.0466 | 0.1022 |
Leishmania major | phenylalanine-4-hydroxylase,phenylalanine-4-hydroxylase, putative | 0.0159 | 0.0466 | 0.5 |
Toxoplasma gondii | aromatic amino acid hydrolase AAH2 | 0.0178 | 0.0797 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0401 | 0.4558 | 0.4558 |
Toxoplasma gondii | phenylalanine-4-hydroxylase | 0.0178 | 0.0797 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.4558 | 0.4558 |
Schistosoma mansoni | tyrosine 3-monooxygenase | 0.0159 | 0.0466 | 0.1022 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0401 | 0.4558 | 0.4558 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0401 | 0.4558 | 1 |
Loa Loa (eye worm) | tryptophan hydroxylase 1 | 0.0159 | 0.0466 | 0.0466 |
Echinococcus multilocularis | serotonin receptor | 0.0401 | 0.4558 | 0.4558 |
Echinococcus multilocularis | tryptophan hydroxylase | 0.0722 | 1 | 1 |
Onchocerca volvulus | 0.0131 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0722 | 1 | 1 |
Brugia malayi | Biopterin-dependent aromatic amino acid hydroxylase family protein | 0.0159 | 0.0466 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.