Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0909 | 0.0909 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0719 | 1 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.022 | 0.2941 | 0.2941 |
Schistosoma mansoni | dihydrofolate reductase | 0.0719 | 1 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.022 | 0.2941 | 0.2941 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0719 | 1 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0909 | 0.0909 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.022 | 0.2941 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0719 | 1 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.022 | 0.2941 | 0.2941 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0909 | 0.0909 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0909 | 0.0909 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0719 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0275 | 0.3717 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.022 | 0.2941 | 0.2941 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0367 | 0.5013 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0909 | 0.0909 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0909 | 0.0909 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0719 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0719 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0719 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0367 | 0.5013 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0719 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0275 | 0.3717 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0909 | 0.0909 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0909 | 0.0909 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0909 | 0.0909 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.5013 | 0.5013 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0367 | 0.5013 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0275 | 0.3717 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.2478 | 0.2478 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.022 | 0.2941 | 0.2941 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0909 | 0.0909 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0909 | 0.0909 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0367 | 0.5013 | 0.5013 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0909 | 0.0909 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0909 | 0.0909 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.