Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.0025 | 0.1023 | 0.1793 |
Schistosoma mansoni | lamin | 0.0025 | 0.1023 | 0.1793 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0202 | 0.0098 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0046 | 0.2701 | 0.2624 |
Echinococcus multilocularis | lamin | 0.0025 | 0.1023 | 0.1023 |
Brugia malayi | RNA binding protein | 0.0058 | 0.3691 | 0.3624 |
Brugia malayi | MH2 domain containing protein | 0.011 | 0.78 | 0.7777 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0202 | 0.0202 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0072 | 0.478 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0013 | 0.0105 | 0.0105 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.3691 | 0.762 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1545 | 0.1545 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.478 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0202 | 0.0202 |
Loa Loa (eye worm) | RNA binding protein | 0.0058 | 0.3691 | 0.3691 |
Echinococcus granulosus | lamin dm0 | 0.0025 | 0.1023 | 0.1023 |
Echinococcus multilocularis | tar DNA binding protein | 0.0058 | 0.3691 | 0.3691 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0138 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0058 | 0.3691 | 0.3691 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2701 | 0.2701 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0072 | 0.478 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.24 | 0.48 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.24 | 0.24 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0046 | 0.2701 | 0.2624 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.3691 | 0.762 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0987 | 0.0987 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0058 | 0.3691 | 0.3624 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.478 | 0.478 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0025 | 0.1023 | 0.1023 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0047 | 0.2805 | 0.4744 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0058 | 0.3691 | 0.3691 |
Loa Loa (eye worm) | intermediate filament protein | 0.0025 | 0.1023 | 0.1023 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0042 | 0.24 | 0.24 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.3691 | 0.762 |
Loa Loa (eye worm) | TAR-binding protein | 0.0058 | 0.3691 | 0.3691 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.3691 | 0.762 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0072 | 0.478 | 0.478 |
Onchocerca volvulus | 0.0025 | 0.1023 | 0.5 | |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0047 | 0.2805 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0202 | 0.0202 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.24 | 0.24 |
Echinococcus granulosus | intermediate filament protein | 0.0025 | 0.1023 | 0.1023 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.478 | 0.5 |
Echinococcus granulosus | lamin | 0.0025 | 0.1023 | 0.1023 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0202 | 0.0202 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0202 | 0.0202 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1545 | 0.2932 |
Echinococcus multilocularis | muscleblind protein | 0.0138 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0.1023 | 0.5 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.011 | 0.78 | 0.78 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0042 | 0.24 | 0.24 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.24 | 0.48 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0047 | 0.2805 | 0.2805 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0202 | 0.0098 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0202 | 0.0202 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.478 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.011 | 0.78 | 0.78 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0025 | 0.1023 | 0.0928 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0047 | 0.2805 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0025 | 0.1023 | 0.1793 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0031 | 0.1545 | 0.1455 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.478 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.478 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0025 | 0.1023 | 0.1023 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0072 | 0.478 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0202 | 0.0202 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0025 | 0.1023 | 0.1023 |
Brugia malayi | Probable ClpP-like protease | 0.0072 | 0.478 | 0.4725 |
Schistosoma mansoni | tar DNA-binding protein | 0.0058 | 0.3691 | 0.762 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0202 | 0.0202 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0042 | 0.24 | 0.2319 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.478 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0042 | 0.24 | 0.48 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0072 | 0.478 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0047 | 0.2805 | 0.2805 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0046 | 0.2701 | 0.2701 |
Brugia malayi | intermediate filament protein | 0.0025 | 0.1023 | 0.0928 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0072 | 0.478 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0138 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0058 | 0.3691 | 0.3624 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0072 | 0.478 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0072 | 0.478 | 0.478 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0042 | 0.24 | 0.24 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1023 | 0.1023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.