Detailed information for compound 896597

Basic information

Technical information
  • TDR Targets ID: 896597
  • Name: N-(2-benzo[g][1,3]benzothiazolyl)-4-butoxyben zamide
  • MW: 376.471 | Formula: C22H20N2O2S
  • H donors: 1 H acceptors: 2 LogP: 6.02 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOc1ccc(cc1)C(=O)Nc1nc2c(s1)c1ccccc1cc2
  • InChi: 1S/C22H20N2O2S/c1-2-3-14-26-17-11-8-16(9-12-17)21(25)24-22-23-19-13-10-15-6-4-5-7-18(15)20(19)27-22/h4-13H,2-3,14H2,1H3,(H,23,24,25)
  • InChiKey: OMEWUSLLMWDVDQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-benzo[g][1,3]benzothiazol-2-yl-4-butoxybenzamide
  • N-benzo[g][1,3]benzothiazol-2-yl-4-butoxy-benzamide
  • ZINC02025799

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0075 0.1461
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0194 0.3762
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0042 0.0667 0.0667
Leishmania major hypothetical protein, conserved 0.0028 0.0194 0.2911
Trichomonas vaginalis glycogen phosphorylase, putative 0.0212 0.643 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0667 0.1037
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0516 0.0802
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0516 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0516 0.7737
Entamoeba histolytica P-glyco protein 6, putative 0.0042 0.0667 0.1037
Loa Loa (eye worm) hypothetical protein 0.0037 0.0516 0.0516
Trichomonas vaginalis ABC transporter, putative 0.0042 0.0667 0.1037
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0667 0.1037
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0041 0.0651 0.0651
Entamoeba histolytica glycogenphosphorylase, putative 0.0092 0.236 0.367
Trichomonas vaginalis ABC transporter, putative 0.0042 0.0667 0.1037
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0042 0.0667 1
Echinococcus multilocularis Glycosyl transferase, family 35 0.0212 0.643 0.643
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0999 0.1553
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0667 0.1037
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0516 0.0516
Brugia malayi beta-lactamase family protein 0.0037 0.0516 0.0802
Loa Loa (eye worm) hypothetical protein 0.0042 0.0667 0.0667
Echinococcus granulosus multidrug resistance protein 1 0.0042 0.0667 0.0667
Brugia malayi RNA, U transporter 1 0.0085 0.2121 0.3298
Entamoeba histolytica glycogen phosphorylase, putative 0.0092 0.236 0.367
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0667 0.1037
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0516 1
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0092 0.236 1
Echinococcus multilocularis multidrug resistance protein 1 0.0042 0.0667 0.0667
Entamoeba histolytica P-glycoprotein-2 0.0042 0.0667 0.1037
Trichomonas vaginalis ABC transporter, putative 0.0042 0.0667 0.1037
Trichomonas vaginalis abcb9, putative 0.0042 0.0667 0.1037
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0042 0.0667 0.0667
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0042 0.0667 0.0667
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0667 0.1037
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0667 0.1037
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0194 0.2911
Schistosoma mansoni multidrug resistance protein 0.0042 0.0667 0.0667
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0042 0.0667 0.1037
Brugia malayi beta-lactamase 0.0037 0.0516 0.0802
Trichomonas vaginalis abcb9, putative 0.0042 0.0667 0.1037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0516 0.0516
Echinococcus granulosus Glycosyl transferase family 35 0.0212 0.643 0.643
Echinococcus granulosus multidrug resistance protein 1 0.0029 0.0242 0.0242
Schistosoma mansoni importin beta-1 0.003 0.0266 0.0266
Leishmania major p-glycoprotein 0.0042 0.0667 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0266 0.3985
Mycobacterium leprae Probable lipase LipE 0.0037 0.0516 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0667 0.1037
Entamoeba histolytica P-glycoprotein-5 0.0042 0.0667 0.1037
Plasmodium vivax multidrug resistance protein 1, putative 0.0042 0.0667 1
Brugia malayi hypothetical protein 0.0028 0.0194 0.0302
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0667 0.1037
Leishmania major importin beta-1 subunit, putative 0.0024 0.0075 0.113
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0092 0.236 0.2724
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0194 0.2911
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0042 0.0667 0.0223
Loa Loa (eye worm) hypothetical protein 0.0037 0.0516 0.0516
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0667 0.1037
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0042 0.0667 0.0667
Schistosoma mansoni hypothetical protein 0.0318 1 1
Schistosoma mansoni hypothetical protein 0.0175 0.5172 0.5172
Onchocerca volvulus 0.0042 0.0667 0.0255
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0266 0.515
Echinococcus multilocularis snurportin 1 0.0318 1 1
Brugia malayi multidrug resistance protein 3 0.0042 0.0667 0.1037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0516 0.0516
Echinococcus multilocularis glycogen phosphorylase 0.0212 0.643 0.643
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0194 0.3762
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0266 0.515
Schistosoma mansoni multidrug resistance protein 0.0042 0.0667 0.0667
Echinococcus granulosus glycogen phosphorylase 0.0212 0.643 0.643
Loa Loa (eye worm) hypothetical protein 0.0037 0.0516 0.0516
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0516 1
Entamoeba histolytica P-glycoprotein-2 0.0042 0.0667 0.1037
Entamoeba histolytica P-glycoprotein-1 0.0042 0.0667 0.1037
Schistosoma mansoni glycogen phosphorylase 0.0092 0.236 0.236
Brugia malayi Importin beta-1 subunit 0.003 0.0266 0.0413
Loa Loa (eye worm) multidrug resistance protein 3 0.0042 0.0667 0.0667
Trichomonas vaginalis glycogen phosphorylase, putative 0.0212 0.643 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0449 0.0698
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0516 0.0802
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 1 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0266 0.0266
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0516 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0667 0.1037
Schistosoma mansoni glycogen phosphorylase 0.0212 0.643 0.643
Echinococcus multilocularis geminin 0.0175 0.5172 0.5172
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0029 0.0242 0.0376
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0516 0.0516
Trichomonas vaginalis abcb9, putative 0.0042 0.0667 0.1037
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0194 0.2911
Trichomonas vaginalis taga, putative 0.0042 0.0667 0.1037
Echinococcus granulosus geminin 0.0175 0.5172 0.5172
Loa Loa (eye worm) hypothetical protein 0.0037 0.0516 0.0516
Toxoplasma gondii ABC1 family protein 0.0037 0.0516 0.7737
Loa Loa (eye worm) glycogen phosphorylase 0.0212 0.643 0.643
Echinococcus multilocularis multidrug resistance protein 1 0.0042 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0042 0.0667 0.0667
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0667 0.1037
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0042 0.0667 0.1037
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0075 0.0117
Schistosoma mansoni multidrug resistance protein 0.0042 0.0667 0.0667
Trichomonas vaginalis ABC transporter, putative 0.0042 0.0667 0.1037
Plasmodium falciparum multidrug resistance protein 1 0.0042 0.0667 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.003 0.0266 0.0266
Schistosoma mansoni hypothetical protein 0.0035 0.0449 0.0449
Brugia malayi carbohydrate phosphorylase 0.0212 0.643 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0999 0.1553
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0999 0.0999
Schistosoma mansoni glycogen phosphorylase 0.0212 0.643 0.643
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0667 0.0667
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0667 0.0667
Giardia lamblia Glycogen phosphorylase 0.0212 0.643 1
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0075 0.0117
Loa Loa (eye worm) hypothetical protein 0.0028 0.0194 0.0194
Loa Loa (eye worm) beta-lactamase 0.0037 0.0516 0.0516
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0667 0.1037
Echinococcus multilocularis multidrug resistance protein 1 0.0029 0.0242 0.0242
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0075 0.0117
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0667 0.0667
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0516 0.0802
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0042 0.0667 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0516 0.0516
Entamoeba histolytica glycogen phosphorylase, putative 0.0212 0.643 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0516 0.0802
Echinococcus multilocularis ATP binding cassette sub family B 0.0041 0.0651 0.0651
Brugia malayi beta-lactamase family protein 0.0037 0.0516 0.0802
Loa Loa (eye worm) hypothetical protein 0.0037 0.0516 0.0516
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0667 0.1037
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0194 0.2911
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0667 0.1037
Entamoeba histolytica P-glycoprotein 5, putative 0.0042 0.0667 0.1037
Schistosoma mansoni smdr2 0.0042 0.0667 0.0667
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0042 0.0667 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0516 0.0802
Entamoeba histolytica P-glycoprotein-2, putative 0.0042 0.0667 0.1037
Onchocerca volvulus Glycogen phosphorylase homolog 0.0212 0.643 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0667 0.1037
Loa Loa (eye worm) hypothetical protein 0.0041 0.0651 0.0651
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0667 0.1037
Loa Loa (eye worm) hypothetical protein 0.0037 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0035 0.0449 0.0449
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0042 0.0667 0.0667
Brugia malayi ABC transporter family protein 0.0042 0.0667 0.1037
Entamoeba histolytica glycogen phosphorylase, putative 0.0212 0.643 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0667 0.1037
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0667 0.0667
Plasmodium vivax importin-beta 2, putative 0.003 0.0266 0.3985
Entamoeba histolytica glycogen phosphorylase, putative 0.0092 0.236 0.367
Echinococcus granulosus glycogen phosphorylase 0.0212 0.643 0.643
Plasmodium falciparum importin beta, putative 0.003 0.0266 0.3985
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0667 0.1037
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0516 0.0802
Loa Loa (eye worm) hypothetical protein 0.0051 0.0999 0.0999
Schistosoma mansoni hypothetical protein 0.0175 0.5172 0.5172
Echinococcus granulosus importin subunit beta 1 0.003 0.0266 0.0266
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0667 0.1037
Trichomonas vaginalis esterase, putative 0.0037 0.0516 0.0802
Echinococcus granulosus multidrug resistance protein 1 0.0042 0.0667 0.0667
Entamoeba histolytica hypothetical protein 0.0024 0.0075 0.0117
Chlamydia trachomatis glycogen phosphorylase 0.0212 0.643 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0667 0.1037
Echinococcus granulosus multidrug resistance protein 1 0.0029 0.0242 0.0242
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0194 0.3762
Leishmania major hypothetical protein, conserved 0.0037 0.0516 0.7737
Echinococcus multilocularis glycogen phosphorylase 0.0212 0.643 0.643
Echinococcus granulosus multidrug resistance protein 1 0.0042 0.0667 0.0667
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.7286 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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