TDR Targets

Basic information

Technical information

TDR Targets ID: 897020
Name: ZINC02479151
MW: 312.366 | Formula: C17H20N4O2
H donors: 1 H acceptors: 3 LogP: 3.21 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCn1c2nc3ccccc3nc2c(c1N)C(=O)OC
InChi: 1S/C17H20N4O2/c1-3-4-7-10-21-15(18)13(17(22)23-2)14-16(21)20-12-9-6-5-8-11(12)19-14/h5-6,8-9H,3-4,7,10,18H2,1-2H3
InChiKey: PEHCLEWOBIHBRW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ST5136702

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	G protein-coupled receptor kinase 6	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	G protein coupled receptor kinase 6	Get druggable targets OG5_130334	All targets in OG5_130334
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	Get druggable targets OG5_130334	All targets in OG5_130334
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	Get druggable targets OG5_130334	All targets in OG5_130334
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	Get druggable targets OG5_130334	All targets in OG5_130334
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	Get druggable targets OG5_130334	All targets in OG5_130334
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	Get druggable targets OG5_130334	All targets in OG5_130334
Schistosoma japonicum	ko:K08291 G protein-coupled receptor kinase [EC2.7.11.16], putative	Get druggable targets OG5_130334	All targets in OG5_130334
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_130334	All targets in OG5_130334
Schistosoma japonicum	G protein-coupled receptor kinase 1, putative	Get druggable targets OG5_130334	All targets in OG5_130334
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	Get druggable targets OG5_130334	All targets in OG5_130334

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.003	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.002	0.0172	0.0359
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Schistosoma mansoni	serine/threonine protein kinase	0.0155	0.4783	0.4783
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Schistosoma mansoni	opsin-like receptor	0.002	0.0172	0.0172
Echinococcus granulosus	g protein coupled receptor	0.002	0.0172	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.003	0.0063
Echinococcus multilocularis	allatostatin A receptor	0.002	0.0172	0.0172
Leishmania major	cathepsin L-like protease	0.0062	0.1604	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.002	0.0172	0.0172
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.002	0.0172	0.0359
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0013	0.0013
Brugia malayi	hypothetical protein	0.002	0.0172	0.0359
Schistosoma mansoni	neuropeptide receptor	0.002	0.0172	0.0172
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.003	0.5
Echinococcus granulosus	neuropeptide receptor	0.002	0.0172	0.0172
Schistosoma mansoni	biogenic amine receptor	0.002	0.0172	0.0172
Brugia malayi	Cathepsin L-like precursor	0.0016	0.003	0.0063
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.002	0.0172	0.0172
Onchocerca volvulus		0.002	0.0172	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.002	0.0172	0.0172
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1604	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.002	0.0172	0.0172
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.002	0.0172	0.0172
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0172	0.0172
Echinococcus granulosus	neuropeptide Y receptor	0.002	0.0172	0.0172
Brugia malayi	AKH receptor	0.002	0.0172	0.0359
Brugia malayi	larval opioid receptor	0.002	0.0172	0.0359
Echinococcus multilocularis	neuropeptide Y receptor	0.002	0.0172	0.0172
Schistosoma mansoni	amine GPCR	0.002	0.0172	0.0172
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.003	0.003
Brugia malayi	ORL1-like opioid receptor	0.002	0.0172	0.0359
Echinococcus multilocularis	neuropeptides capa receptor	0.002	0.0172	0.0172
Echinococcus multilocularis	serotonin receptor	0.0307	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Schistosoma mansoni	neuropeptide receptor	0.002	0.0172	0.0172
Onchocerca volvulus		0.002	0.0172	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.002	0.0172	0.0172
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.002	0.0172	0.0359
Schistosoma mansoni	hypothetical protein	0.002	0.0172	0.0172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0172	0.0172
Onchocerca volvulus		0.002	0.0172	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.003
Brugia malayi	hypothetical protein	0.002	0.0172	0.0359
Brugia malayi	Dopamine receptor protein 2	0.002	0.0172	0.0359
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.002	0.0172	0.0172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1604	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Schistosoma mansoni	biogenic amine receptor	0.002	0.0172	0.0172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0172	0.0172
Echinococcus multilocularis	neuropeptide receptor A26	0.002	0.0172	0.0172
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0139	0.4253	0.4253
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.1604	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Schistosoma mansoni	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.002	0.0172	0.0172
Echinococcus granulosus	neuropeptide Y receptor	0.002	0.0172	0.0172
Echinococcus granulosus	allatostatin A receptor	0.002	0.0172	0.0172
Echinococcus granulosus	hypothetical protein	0.002	0.0172	0.0172
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0016	0.0013	0.0013
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0172	0.0172
Echinococcus multilocularis	G protein coupled receptor 139	0.002	0.0172	0.0172
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Brugia malayi	hypothetical protein	0.002	0.0172	0.0359
Brugia malayi	neuropeptide F receptor	0.002	0.0172	0.0359
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0172	0.0172
Echinococcus granulosus	somatostatin receptor	0.002	0.0172	0.0172
Brugia malayi	neuropeptide F receptor	0.002	0.0172	0.0359
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1604	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.002	0.0172	0.0172
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.002	0.0172	0.0172
Brugia malayi	hypothetical protein	0.002	0.0172	0.0359
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0172	0.0172
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0172	0.0172
Schistosoma mansoni	neuropeptide F-like receptor	0.002	0.0172	0.0172
Onchocerca volvulus		0.002	0.0172	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.002	0.0172	0.0359
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.002	0.0172	0.0172
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.002	0.0172	1
Echinococcus multilocularis	fmrfamide receptor	0.002	0.0172	0.0172
Brugia malayi	Cathepsin L-like precursor	0.0016	0.003	0.0063
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.002	0.0172	0.0172
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.003	0.003
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.003	0.003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Echinococcus granulosus	tachykinin peptides receptor 99D	0.002	0.0172	0.0172
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.002	0.0172	0.0172
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.1604	1
Onchocerca volvulus		0.002	0.0172	1
Echinococcus multilocularis	orexin receptor type 2	0.002	0.0172	0.0172
Echinococcus granulosus	dro:myosuppressin receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	G-protein coupled receptor	0.002	0.0172	0.0172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.1604	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Brugia malayi	hypothetical protein	0.002	0.0172	0.0359
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.003	0.003
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0155	0.4783	0.4783
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1604	0.5
Brugia malayi	G protein-coupled receptor	0.002	0.0172	0.0359
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.002	0.0172	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Schistosoma mansoni	opsin-like receptor	0.002	0.0172	0.0172
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.002	0.0172	0.0359
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.003	1
Echinococcus granulosus	neuropeptide receptor A26	0.002	0.0172	0.0172
Schistosoma mansoni	amine GPCR	0.002	0.0172	0.0172
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.002	0.0172	0.0172
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.003	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0307	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.002	0.0172	0.0172
Schistosoma mansoni	neuropeptide F-like receptor	0.002	0.0172	0.0172
Schistosoma mansoni	amine GPCR	0.002	0.0172	0.0172
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Brugia malayi	sulfakinin receptor protein	0.002	0.0172	0.0359
Echinococcus multilocularis	neuropeptide receptor	0.002	0.0172	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.003	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Onchocerca volvulus		0.002	0.0172	1
Onchocerca volvulus		0.002	0.0172	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Echinococcus multilocularis	G-protein coupled receptor, putative	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.003	0.003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Loa Loa (eye worm)	G-protein coupled receptor	0.002	0.0172	0.0172
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.1419	0.8824
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0139	0.4253	0.4253
Brugia malayi	G-protein coupled receptor	0.002	0.0172	0.0359
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.003	0.003
Schistosoma mansoni	amine GPCR	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0172	0.0172
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.002	0.0172	0.0172
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.002	0.0172	0.0172
Echinococcus granulosus	sex peptide receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.1147	0.7098
Loa Loa (eye worm)	hypothetical protein	0.0307	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.002	0.0172	0.0359
Schistosoma mansoni	histamine h1 receptor	0.002	0.0172	0.0172
Onchocerca volvulus		0.002	0.0172	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.002	0.0172	0.0172
Echinococcus multilocularis	cysteine protease	0.0016	0.003	0.003
Brugia malayi	hypothetical protein	0.002	0.0172	0.0359
Brugia malayi	Serotonin receptor	0.002	0.0172	0.0359
Loa Loa (eye worm)	ctsf protein	0.0016	0.003	0.003
Brugia malayi	G-protein coupled receptor	0.002	0.0172	0.0359
Echinococcus granulosus	peptide allatostatin:somatostatin	0.002	0.0172	0.0172
Toxoplasma gondii	cathepsin CPL	0.0016	0.003	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0172	0.0172
Plasmodium vivax	vivapain-2	0.0016	0.003	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.003	0.003
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0016	0.0013	0.0013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Entamoeba histolytica	cysteine protease, putative	0.0016	0.003	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Echinococcus granulosus	neuropeptide FF receptor 2	0.002	0.0172	0.0172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1604	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1604	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.002	0.0172	0.0172
Echinococcus granulosus	neuropeptides capa receptor	0.002	0.0172	0.0172
Echinococcus multilocularis	g-protein coupled receptor	0.002	0.0172	0.0172
Brugia malayi	G protein-coupled receptor F59B2.13	0.002	0.0172	0.0359
Echinococcus granulosus	alpha 1A adrenergic receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	neuropeptide F receptor	0.002	0.0172	0.0172
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0172	0.0172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1604	0.5
Brugia malayi	follicle stimulating hormone receptor	0.002	0.0172	0.0359
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Onchocerca volvulus		0.002	0.0172	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Schistosoma mansoni	hypothetical protein	0.002	0.0172	0.0172
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0139	0.4253	0.4253
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.002	0.0172	0.0172
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.002	0.0172	0.0172
Brugia malayi	putative neuropeptide receptor NPR1	0.002	0.0172	0.0359
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0155	0.4783	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.003	0.0063
Brugia malayi	Serotonin receptor	0.002	0.0172	0.0359
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0307	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0172	0.0172
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.002	0.0172	0.0172
Brugia malayi	hypothetical protein	0.002	0.0172	0.0359
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	1
Brugia malayi	hypothetical protein	0.002	0.0172	0.0359
Echinococcus multilocularis	somatostatin receptor	0.002	0.0172	0.0172
Echinococcus granulosus	biogenic amine 5HT receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0172	0.0172
Brugia malayi	putative neuropeptide receptor	0.002	0.0172	0.0359
Echinococcus multilocularis	neuropeptide receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1604	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Echinococcus granulosus	7tm_1 domain containing protein	0.002	0.0172	0.0172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Loa Loa (eye worm)	TYRA-2 protein	0.002	0.0172	0.0172
Echinococcus granulosus	g protein coupled receptor	0.002	0.0172	0.0172
Echinococcus granulosus	neuropeptide receptor	0.002	0.0172	0.0172
Leishmania major	cathepsin L-like protease	0.0062	0.1604	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.002	0.0172	0.0172
Echinococcus granulosus	g-protein coupled receptor	0.002	0.0172	0.0172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1604	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Echinococcus granulosus	G protein coupled receptor 139	0.002	0.0172	0.0172
Echinococcus multilocularis	neuropeptide s receptor	0.002	0.0172	0.0172
Echinococcus multilocularis	fmrfamide receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Brugia malayi	RE15519p	0.002	0.0172	0.0359
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.002	0.0172	0.0172
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.1604	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Echinococcus multilocularis	cysteine protease	0.0016	0.003	0.003
Loa Loa (eye worm)	fibroinase	0.0016	0.003	0.003
Echinococcus granulosus	orexin receptor type 2	0.002	0.0172	0.0172
Onchocerca volvulus		0.002	0.0172	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.002	0.0172	0.0172
Echinococcus multilocularis	sex peptide receptor	0.002	0.0172	0.0172
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.003	0.003
Echinococcus granulosus	serotonin receptor	0.002	0.0172	0.0172
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0172	0.0172
Echinococcus multilocularis	dro:myosuppressin receptor	0.002	0.0172	0.0172
Schistosoma mansoni	hypothetical protein	0.002	0.0172	0.0172
Plasmodium vivax	vivapain-2	0.0016	0.003	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.002	0.0172	0.0172
Brugia malayi	Cathepsin L-like precursor	0.0016	0.003	0.0063
Schistosoma mansoni	biogenic amine receptor	0.002	0.0172	0.0172
Schistosoma mansoni	opsin-like receptor	0.002	0.0172	0.0172
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0172	0.0172
Brugia malayi	Dopamine receptor	0.002	0.0172	0.0359
Brugia malayi	GnHR receptor homolog	0.002	0.0172	0.0359
Brugia malayi	Cathepsin L-like precursor	0.0016	0.003	0.0063
Schistosoma mansoni	neuropeptide receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	cysteine protease	0.0016	0.003	0.003
Onchocerca volvulus		0.002	0.0172	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	1
Brugia malayi	hypothetical protein	0.002	0.0172	0.0359
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Schistosoma mansoni	neuropeptide receptor	0.002	0.0172	0.0172
Echinococcus granulosus	rhodopsin orphan GPCR	0.002	0.0172	0.0172
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.003	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.002	0.0172	0.0172
Onchocerca volvulus		0.002	0.0172	1
Echinococcus granulosus	fmrfamide receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0016	0.0013	0.0013
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.002	0.0172	0.0172
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	1
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0139	0.4253	0.4253
Onchocerca volvulus		0.002	0.0172	1
Schistosoma mansoni	adenoreceptor	0.002	0.0172	0.0172
Schistosoma mansoni	biogenic amine (5HT) receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1604	0.5
Onchocerca volvulus		0.002	0.0172	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.003	0.5
Onchocerca volvulus		0.002	0.0172	1
Brugia malayi	Melatonin receptor type 1A	0.002	0.0172	0.0359
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.002	0.0172	0.0172
Echinococcus granulosus	g protein coupled receptor	0.002	0.0172	0.0172
Echinococcus multilocularis	neuropeptide Y receptor	0.002	0.0172	0.0172
Echinococcus granulosus	cathepsin l1	0.0016	0.003	0.003
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.002	0.0172	0.0172
Onchocerca volvulus	Neuropeptide F receptor homolog	0.002	0.0172	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.002	0.0172	0.0172
Onchocerca volvulus		0.002	0.0172	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	1
Echinococcus multilocularis	g protein coupled receptor	0.002	0.0172	0.0172
Schistosoma mansoni	neuropeptide f receptor 76f	0.002	0.0172	0.0172
Schistosoma mansoni	alpha-1 adrenergic receptor	0.002	0.0172	0.0172
Leishmania major	cathepsin L-like protease	0.0062	0.1604	1
Schistosoma mansoni	myosin xvIII	0.002	0.0172	0.0172
Schistosoma mansoni	serine/threonine protein kinase	0.0016	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Echinococcus multilocularis	neuropeptide FF receptor 2	0.002	0.0172	0.0172
Brugia malayi	hypothetical protein	0.002	0.0172	0.0359
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Schistosoma mansoni	amine GPCR	0.002	0.0172	0.0172
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.003	1
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0139	0.4253	0.8892
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.1604	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.002	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Brugia malayi	Dopamine receptor protein 1	0.002	0.0172	0.0359
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.002	0.0172	0.0172
Echinococcus granulosus	tm gpcr rhodopsin	0.002	0.0172	0.0172
Echinococcus granulosus	neuropeptide s receptor	0.002	0.0172	0.0172
Onchocerca volvulus		0.002	0.0172	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.002	0.0172	0.0172
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.003	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.003	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0172	0.0172
Echinococcus multilocularis	serotonin receptor	0.0307	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.03 uM	Inhibition of human recombinant full-length GST-tagged human GRK6 using peptide substrate peptide-216 incubated for 7 hrs	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 897020