Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0335 | 0.0301 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0401 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1155 | 0.1155 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0035 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.005 | 0.0753 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.065 | 0.065 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0401 | 0.039 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0045 | 0.001 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0492 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.2022 | 0.1994 |
Echinococcus granulosus | lamin | 0.003 | 0.0335 | 0.0323 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0335 | 0.0323 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.065 | 0.0618 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0219 | 0.4294 | 0.2847 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.065 | 0.064 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0379 | 0.0345 |
Loa Loa (eye worm) | Poly(ADP-ribose) glycohydrolase | 0.0492 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1824 | 0.1824 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0379 | 0.0345 |
Onchocerca volvulus | 0.0033 | 0.0401 | 0.0137 | |
Echinococcus multilocularis | geminin | 0.0166 | 0.3193 | 0.3185 |
Echinococcus multilocularis | musashi | 0.003 | 0.0335 | 0.0323 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0753 | 0.0721 |
Echinococcus granulosus | geminin | 0.0166 | 0.3193 | 0.3185 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0379 | 0.0368 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0401 | 0.0368 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0401 | 0.0368 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.065 | 0.064 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0384 | 0.035 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.1155 | 0.1125 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0036 | 0.046 | 0.5916 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.046 | 0.5916 |
Schistosoma mansoni | lamin | 0.003 | 0.0335 | 0.0301 |
Brugia malayi | hypothetical protein | 0.005 | 0.0753 | 0.0721 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0401 | 0.0368 |
Brugia malayi | DnaJ domain containing protein | 0.0064 | 0.1049 | 0.1018 |
Brugia malayi | hypothetical protein | 0.011 | 0.2022 | 0.1994 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0379 | 0.0368 |
Echinococcus granulosus | polyADP ribose glycohydrolase | 0.0492 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0379 | 0.0379 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.1049 | 0.1018 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.005 | 0.0753 | 0.0721 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0379 | 0.0345 |
Schistosoma mansoni | poly(ADP-ribose) glycohydrolase | 0.0492 | 1 | 1 |
Echinococcus multilocularis | dnaJ subfamily C 6 | 0.0064 | 0.1049 | 0.1039 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0036 | 0.046 | 0.5916 |
Echinococcus multilocularis | lamin | 0.003 | 0.0335 | 0.0323 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0335 | 0.0323 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0219 | 0.4294 | 0.4274 |
Echinococcus multilocularis | poly(ADP ribose) glycohydrolase | 0.0492 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0323 | 0.0323 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.065 | 0.0618 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0035 | 0.0035 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.1824 | 0.1796 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0335 | 0.0301 |
Entamoeba histolytica | hypothetical protein | 0.0219 | 0.4294 | 0.2847 |
Entamoeba histolytica | hypothetical protein | 0.0492 | 1 | 1 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0036 | 0.046 | 0.0427 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0492 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.065 | 0.064 |
Trypanosoma brucei | poly(ADP-ribose) glycohydrolase, putative | 0.0492 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0401 | 0.0368 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0035 | 0.0023 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0035 | 0.0023 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0379 | 0.0368 |
Trichomonas vaginalis | set domain proteins, putative | 0.0262 | 0.5195 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0379 | 0.0368 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0401 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0335 | 0.0335 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0036 | 0.046 | 0.0427 |
Echinococcus granulosus | dnaJ subfamily C 6 | 0.0064 | 0.1049 | 0.1039 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0035 | 0.0023 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.1155 | 0.1125 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0036 | 0.046 | 0.0427 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0401 | 0.039 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0335 | 0.0335 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0035 | 0.0023 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0379 | 0.0368 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.011 | 0.2022 | 0.2013 |
Brugia malayi | Pre-SET motif family protein | 0.023 | 0.4529 | 0.451 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0379 | 0.0368 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0753 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0401 | 0.5101 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0401 | 0.0401 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.065 | 0.0618 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0379 | 0.0345 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0178 | 0.0144 |
Schistosoma mansoni | lamin | 0.003 | 0.0335 | 0.0301 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0379 | 0.0379 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.1824 | 0.1796 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0022 | 0.0178 | 0.0167 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0492 | 1 | 1 |
Loa Loa (eye worm) | DnaJ domain-containing protein | 0.0064 | 0.1049 | 0.1049 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0335 | 0.0301 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0035 | 0.0023 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0036 | 0.046 | 0.0449 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0401 | 0.0368 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.1824 | 0.1824 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.011 | 0.2022 | 0.2013 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.005 | 0.0753 | 0.0721 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.3193 | 0.3169 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0379 | 0.0345 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0036 | 0.046 | 0.0427 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.065 | 0.064 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.005 | 0.0753 | 0.0721 |
Brugia malayi | Augmenter of liver regeneration | 0.0036 | 0.046 | 0.0427 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0022 | 0.0178 | 0.0167 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0045 | 0.0045 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.3193 | 0.3169 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0753 | 0.0753 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0335 | 0.0335 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0036 | 0.046 | 0.0449 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.005 | 0.0753 | 1 |
Onchocerca volvulus | 0.0262 | 0.5195 | 1 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.011 | 0.2022 | 0.1994 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0036 | 0.046 | 0.0427 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.023 | 0.4529 | 0.4529 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0035 | 0.0023 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0376 | 0.0365 |
Leishmania major | hypothetical protein, conserved | 0.005 | 0.0753 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.065 | 0.0618 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0036 | 0.046 | 0.0427 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0036 | 0.046 | 0.046 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0492 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0379 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0011 | 0.0011 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0335 | 0.0323 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.