Detailed information for compound 902441

Basic information

Technical information
  • TDR Targets ID: 902441
  • Name: 4-amino-N-methyl-N-phenylbenzamide
  • MW: 226.274 | Formula: C14H14N2O
  • H donors: 1 H acceptors: 1 LogP: 2.26 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)C(=O)N(c1ccccc1)C
  • InChi: 1S/C14H14N2O/c1-16(13-5-3-2-4-6-13)14(17)11-7-9-12(15)10-8-11/h2-10H,15H2,1H3
  • InChiKey: CRHKLAPXNLGNBS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-amino-N-methyl-N-phenyl-benzamide
  • ARONIS014346
  • Oprea1_000993
  • ZINC00225995

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neutral alpha glucosidase AB 0.018 0.009 0.009
Trichomonas vaginalis alpha-L-fucosidase, putative 0.025 0.0833 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0192 0.0214 0.0125
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.1105 1 1
Schistosoma mansoni alpha-l-fucosidase 0.0569 0.4257 0.4531
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.018 0.009 0.5
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0192 0.0214 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.009 0.5
Trichomonas vaginalis alpha-L-fucosidase, putative 0.025 0.0833 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0192 0.0214 0.0125
Echinococcus multilocularis lysosomal alpha glucosidase 0.1105 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.018 0.009 0.5
Loa Loa (eye worm) hypothetical protein 0.0192 0.0214 0.0125
Loa Loa (eye worm) alpha-L-fucosidase 0.0569 0.4257 0.4204
Mycobacterium ulcerans alpha-L-fucosidase 0.0941 0.8245 0.5
Loa Loa (eye worm) tyrosinase 1 0.0192 0.0214 0.0125
Schistosoma mansoni alpha-glucosidase 0.1048 0.9395 1
Echinococcus multilocularis transient receptor potential cation channel 0.0175 0.0038 0.0038
Schistosoma mansoni alpha glucosidase 0.018 0.009 0.0096
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.018 0.009 0.5
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0192 0.0214 0.0125
Echinococcus granulosus transient receptor potential cation channel 0.0175 0.0038 0.0038
Trypanosoma brucei glucosidase, putative 0.018 0.009 0.5
Echinococcus granulosus lysosomal alpha glucosidase 0.1105 1 1
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0941 0.8245 0.8245
Brugia malayi Alpha-L-fucosidase family protein 0.0569 0.4257 0.4204
Brugia malayi ShTK domain containing protein 0.0192 0.0214 0.0125
Schistosoma mansoni alpha-glucosidase 0.1048 0.9395 1
Onchocerca volvulus 0.0867 0.745 1
Leishmania major alpha glucosidase II subunit, putative 0.018 0.009 0.5
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0789 0.6619 0.7046
Schistosoma mansoni tyrosinase precursor 0.0192 0.0214 0.0228
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0192 0.0214 0.0125
Brugia malayi Common central domain of tyrosinase family protein 0.0192 0.0214 0.0125
Schistosoma mansoni tyrosinase precursor 0.0192 0.0214 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.009 0.5
Echinococcus multilocularis neutral alpha glucosidase AB 0.018 0.009 0.009
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0192 0.0214 0.0125
Loa Loa (eye worm) hypothetical protein 0.0192 0.0214 0.0125
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0941 0.8245 0.8245
Echinococcus multilocularis lysosomal alpha glucosidase 0.1105 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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