Detailed information for compound 902911

Basic information

Technical information
  • TDR Targets ID: 902911
  • Name: 3-(3-methoxyphenyl)-5-[(3-methylphenoxy)methy l]-1,2,4-oxadiazole
  • MW: 296.321 | Formula: C17H16N2O3
  • H donors: 0 H acceptors: 2 LogP: 3.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)c1noc(n1)COc1cccc(c1)C
  • InChi: 1S/C17H16N2O3/c1-12-5-3-8-15(9-12)21-11-16-18-17(19-22-16)13-6-4-7-14(10-13)20-2/h3-10H,11H2,1-2H3
  • InChiKey: HFFRBBWIGGPVOL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • STK237494
  • ZINC04866656

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0087 0.6767 0.6767
Brugia malayi hypoxia-induced factor 1 0.0113 0.9131 0.9131
Entamoeba histolytica leucine rich repeat / protein phosphatase 2C domain containing protein 0.0088 0.6778 0.5
Trichomonas vaginalis protein phosphatase type 2C, putative 0.0088 0.6778 0.5
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0046 0.2957 0.4618
Brugia malayi bHLH-PAS transcription factor 0.0027 0.1258 0.1258
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0043 0.2726 0.9221
Onchocerca volvulus Glutaminyl cyclase homolog 0.0083 0.6403 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0602 0.2036
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0046 0.2957 1
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0083 0.6403 1
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0602 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.2957 1
Brugia malayi Peptidase family M28 containing protein 0.0083 0.6403 0.6403
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0602 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0037 0.2127 0.3322
Toxoplasma gondii aldehyde dehydrogenase 0.0046 0.2957 1
Schistosoma mansoni single-minded 0.0037 0.2127 0.3322
Leishmania major cytochrome p450-like protein 0.002 0.0602 0.2036
Trichomonas vaginalis protein phosphatase 2C delta isoform, putative 0.0088 0.6778 0.5
Loa Loa (eye worm) hypoxia-induced factor 1 0.0113 0.9131 0.9131
Mycobacterium ulcerans putative regulatory protein 0.0027 0.1258 0.4256
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.2957 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.004 0.2461 0.2461
Mycobacterium leprae putative cytochrome p450 0.0013 0 0.5
Trypanosoma brucei cytochrome P450, putative 0.002 0.0602 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0046 0.2957 0.4618
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.2957 1
Echinococcus granulosus single minded 2 0.0027 0.1258 0.1965
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0043 0.2726 0.2726
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0043 0.2726 0.4258
Loa Loa (eye worm) hypothetical protein 0.0123 1 1
Brugia malayi PAS domain containing protein 0.0037 0.2127 0.2127
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0043 0.2726 0.9221
Brugia malayi Cytochrome P450 family protein 0.002 0.0602 0.0602
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0046 0.2957 1
Echinococcus multilocularis transfer RNA-Lys 0.0027 0.1258 0.1965
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.2957 0.4618
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0043 0.2726 0.9221
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0083 0.6403 1
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0083 0.6403 0.6403
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0043 0.2726 0.9221
Loa Loa (eye worm) CYP4Cod1 0.002 0.0602 0.0602
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.2957 0.4618
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0043 0.2726 0.4258
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0602 0.0602
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0043 0.2726 0.4258
Trichomonas vaginalis protein phosphatase 2C, putative 0.0088 0.6778 0.5
Mycobacterium leprae Conserved hypothetical protein 0.0013 0 0.5
Brugia malayi Cytochrome P450 family protein 0.002 0.0602 0.0602
Brugia malayi Cytochrome P450 family protein 0.0042 0.2623 0.2623
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.2623 0.2623
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0083 0.6403 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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