TDR Targets

Basic information

Technical information

TDR Targets ID: 905137
Name: (4Z)-4-[(2,4-dichlorophenyl)methylidene]-2-(3 -fluorophenyl)-1,3-oxazol-5-one
MW: 336.145 | Formula: C16H8Cl2FNO2
H donors: 0 H acceptors: 1 LogP: 4.92 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)Cl)C=C1N=C(OC1=O)c1cccc(c1)F
InChi: 1S/C16H8Cl2FNO2/c17-11-5-4-9(13(18)8-11)7-14-16(21)22-15(20-14)10-2-1-3-12(19)6-10/h1-8H/b14-7-
InChiKey: WKISOVVPLMAXPC-AUWJEWJLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4Z)-4-[(2,4-dichlorophenyl)methylene]-2-(3-fluorophenyl)oxazol-5-one
(4Z)-4-[(2,4-dichlorophenyl)methylene]-2-(3-fluorophenyl)-5-oxazolone
(4Z)-4-(2,4-dichlorobenzylidene)-2-(3-fluorophenyl)oxazol-5-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0312	0.0312
Brugia malayi	MH2 domain containing protein	0.014	0.5683	0.5683
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0026	0.0312	0.0312
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.011	0.4296	0.5791
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0026	0.0312	0.0386
Trypanosoma brucei	CAAX amino terminal protease, putative	0.0107	0.4152	1
Trypanosoma brucei	trypanothione reductase	0.0055	0.1704	0.2007
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.014	0.5712	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0026	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0042	0.1089	0.2371
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0026	0.0312	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0026	0.0312	0.0386
Echinococcus multilocularis	ecdysone induced protein 78C	0.0026	0.0312	0.0386
Schistosoma mansoni	peroxidasin	0.0026	0.0302	0.0407
Plasmodium falciparum	thioredoxin reductase	0.0055	0.1704	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0312	0.0312
Loa Loa (eye worm)	steroid hormone receptor	0.0026	0.0312	0.0312
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0026	0.0312	0.0312
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0042	0.1089	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Brugia malayi	photoreceptor-specific nuclear receptor	0.0026	0.0312	0.0312
Loa Loa (eye worm)	MH2 domain-containing protein	0.014	0.5683	0.5683
Brugia malayi	ecdysteroid receptor	0.0026	0.0312	0.0312
Onchocerca volvulus		0.0026	0.0302	0.0703
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0026	0.0312	0.0386
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0138	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0026	0.0312	0.0386
Schistosoma mansoni	alpha glucosidase	0.0042	0.1089	0.1469
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0302	0.0302
Loa Loa (eye worm)	hypothetical protein	0.011	0.4296	0.4296
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0302	0.0302
Loa Loa (eye worm)	glutathione reductase	0.0055	0.1704	0.1704
Onchocerca volvulus		0.0026	0.0302	0.0703
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0026	0.0312	0.0727
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0026	0.0312	0.0421
Echinococcus multilocularis	FTZ F1 alpha	0.0026	0.0312	0.0386
Trypanosoma cruzi	peptidase with unknown catalytic mechanism (family U48)	0.0107	0.4152	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0026	0.0312	0.0312
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0975	0.0975
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0026	0.0312	0.0386
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0107	0.4152	0.5597
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.0302	0.0302
Echinococcus granulosus	peroxidasin	0.0026	0.0302	0.0373
Onchocerca volvulus	Peroxidasin homolog	0.0026	0.0302	0.0703
Mycobacterium tuberculosis	Probable oxidoreductase	0.014	0.5712	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0312	0.0312
Schistosoma mansoni	peroxidasin	0.0026	0.0302	0.0407
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0026	0.0312	0.0386
Plasmodium vivax	glutathione reductase, putative	0.0055	0.1704	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0026	0.0312	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Schistosoma mansoni	alpha-glucosidase	0.0164	0.6834	0.9214
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0126	0.5047	0.8808
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.0302	0.0302
Treponema pallidum	hypothetical protein	0.0022	0.0138	0.5
Toxoplasma gondii	thioredoxin reductase	0.0055	0.1704	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0054	0.1631	0.2017
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0055	0.1704	0.2107
Mycobacterium ulcerans	integral membrane protein	0.0022	0.0138	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0026	0.0312	0.0312
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0026	0.0312	0.0386
Trichomonas vaginalis	Clan U, family U48, CaaX prenyl peptidase 2-like	0.0107	0.4152	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0026	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.004	0.0975	0.0975
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0026	0.0312	0.0421
Entamoeba histolytica	CAAX prenyl protease family	0.0107	0.4152	1
Schistosoma mansoni	lipoxygenase	0.0054	0.1631	0.2198
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0026	0.0312	0.0386
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0026	0.0312	0.0312
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0026	0.0312	0.0312
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0302	0.0302
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0026	0.0312	0.0386
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0042	0.1089	0.2371
Trypanosoma cruzi	CAAX prenyl protease 2, putative	0.0107	0.4152	1
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.0302	0.0302
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0026	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0042	0.1089	0.1089
Schistosoma mansoni	nuclear hormone receptor	0.0026	0.0312	0.0421
Onchocerca volvulus	Dual oxidase homolog	0.0026	0.0302	0.0703
Schistosoma mansoni	thyroid hormone receptor	0.0026	0.0312	0.0421
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0026	0.0312	0.0312
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0026	0.0312	0.0386
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.1619	0.2002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.1619	0.2002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0026	0.0312	0.0312
Brugia malayi	glutathione reductase	0.0055	0.1704	0.1704
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0026	0.0312	0.0421
Echinococcus granulosus	CAAX prenyl protease 2	0.0107	0.4152	0.5134
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0026	0.0312	0.0312
Echinococcus granulosus	FTZ F1 alpha	0.0026	0.0312	0.0386
Echinococcus multilocularis	peroxidasin	0.0026	0.0302	0.0373
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0026	0.0312	0.0386
Echinococcus granulosus	thioredoxin glutathione reductase	0.0055	0.1704	0.2107
Brugia malayi	Nuclear hormone receptor-like 1	0.0026	0.0312	0.0312
Loa Loa (eye worm)	transcription factor SMAD2	0.014	0.5683	0.5683
Chlamydia trachomatis	hypothetical protein	0.0022	0.0138	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0026	0.0312	0.0312
Onchocerca volvulus	Protein ultraspiracle homolog	0.0026	0.0312	0.0727
Brugia malayi	nuclear hormone receptor	0.0026	0.0312	0.0312
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.1619	0.2182
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0042	0.1089	0.1089
Echinococcus multilocularis	CAAX prenyl protease 2	0.0107	0.4152	0.5134
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Onchocerca volvulus	Chorion peroxidase homolog	0.0026	0.0302	0.0703
Schistosoma mansoni	hypothetical protein	0.004	0.0975	0.1314
Leishmania major	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	0.0107	0.4152	1
Onchocerca volvulus		0.0026	0.0312	0.0727
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.0302	0.0302
Onchocerca volvulus	Peroxidase homolog	0.0026	0.0302	0.0703
Echinococcus granulosus	neutral alpha glucosidase AB	0.0042	0.1089	0.1347
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0026	0.0312	0.0421
Echinococcus granulosus	ecdysone induced protein 78C	0.0026	0.0312	0.0386
Onchocerca volvulus	Peroxidasin homolog	0.0026	0.0302	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1846	0.1846
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0026	0.0312	0.0386
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.1846	0.1846
Mycobacterium tuberculosis	Probable dehydrogenase	0.0126	0.5047	0.8808
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0026	0.0312	0.0312
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.011	0.4296	0.5791
Brugia malayi	Thioredoxin reductase	0.0055	0.1704	0.1704
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.1619	0.1619
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.1619	0.2002
Loa Loa (eye worm)	hypothetical protein	0.011	0.4296	0.4296
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0026	0.0312	0.0421
Mycobacterium tuberculosis	Probable reductase	0.0126	0.5047	0.8808
Onchocerca volvulus		0.0103	0.3956	0.9211
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0107	0.4152	0.5597
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.1619	0.1619
Brugia malayi	Blistered cuticle protein 3	0.0026	0.0302	0.0302
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0231	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0055	0.1704	0.2007
Brugia malayi	Steroid receptor seven-up type 2	0.0026	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0312	0.0312
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0302	0.0302
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0191	0.8087	1
Brugia malayi	steroid hormone receptor	0.0026	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0312	0.0312
Plasmodium falciparum	glutathione reductase	0.0055	0.1704	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0054	0.1631	0.2017
Leishmania major	trypanothione reductase	0.0055	0.1704	0.2007
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.1619	0.2002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0026	0.0312	0.0312
Plasmodium vivax	protease, putative	0.0022	0.0138	0.0808
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0026	0.0312	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0026	0.0312	0.0386
Onchocerca volvulus		0.011	0.4296	1
Plasmodium vivax	thioredoxin reductase, putative	0.0055	0.1704	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0026	0.0312	0.0312
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0026	0.0312	0.0312
Brugia malayi	hypothetical protein	0.0026	0.0302	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0312	0.0312
Onchocerca volvulus		0.0026	0.0302	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0312	0.0312
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0138	0.5
Loa Loa (eye worm)	thioredoxin reductase	0.0055	0.1704	0.1704
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0042	0.1089	0.6077
Brugia malayi	Peroxidasin	0.0026	0.0302	0.0302
Loa Loa (eye worm)	blistered cuticle protein 3	0.0026	0.0302	0.0302
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0302	0.0302
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0126	0.5047	0.8808
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0026	0.0312	0.0421
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0126	0.5047	0.8808
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.014	0.5712	1
Brugia malayi	Trypsin family protein	0.011	0.4296	0.4296
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0026	0.0312	0.0312
Plasmodium falciparum	protease, putative	0.0022	0.0138	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.1619	0.2182
Schistosoma mansoni	coup transcription factor	0.0026	0.0312	0.0421
Onchocerca volvulus	Peroxidase homolog	0.0026	0.0302	0.0703
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0191	0.8087	0.8087
Brugia malayi	CAAX amino terminal protease family protein	0.0107	0.4152	0.4152
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.1846	0.1846
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.1846	0.1846
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0191	0.8087	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0107	0.4152	0.4152
Onchocerca volvulus		0.011	0.4295	0.9999
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Giardia lamblia	Hypothetical protein	0.0107	0.4152	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0055	0.1704	0.281
Brugia malayi	nuclear receptor NHR-88	0.0026	0.0312	0.0312
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0026	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0312	0.0312
Schistosoma mansoni	retinoic acid receptor RXR	0.0026	0.0312	0.0421
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.1619	0.2182
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0191	0.8087	0.8087
Schistosoma mansoni	alpha-glucosidase	0.0164	0.6834	0.9214
Echinococcus granulosus	lysosomal alpha glucosidase	0.0191	0.8087	1
Schistosoma mansoni	thyroid hormone receptor	0.0026	0.0312	0.0421
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0126	0.5047	0.8808
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.014	0.5712	1
Onchocerca volvulus	Bile acid receptor homolog	0.0026	0.0312	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0302	0.0302
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0026	0.0312	0.0312

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 905137