TDR Targets

Basic information

Technical information

TDR Targets ID: 905905
Name: 5-fluoro-N-(2-methoxyphenyl)-2-nitrobenzamide
MW: 290.247 | Formula: C14H11FN2O4
H donors: 1 H acceptors: 3 LogP: 2.66 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1NC(=O)c1cc(F)ccc1[N+](=O)[O-]
InChi: 1S/C14H11FN2O4/c1-21-13-5-3-2-4-11(13)16-14(18)10-8-9(15)6-7-12(10)17(19)20/h2-8H,1H3,(H,16,18)
InChiKey: QBPUMDAJNKBPRX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-fluoro-N-(2-methoxyphenyl)-2-nitro-benzamide
Oprea1_521539
EU-0036658

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.023	0.1067	1
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Plasmodium vivax	vivapain-2	0.017	0.0718	0.6747
Echinococcus multilocularis	cathepsin L	0.0096	0.0291	0.0291
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.017	0.0718	0.6733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Trypanosoma cruzi	cysteine proteinase, putative	0.0096	0.0291	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0639	0.345	1
Toxoplasma gondii	kinesin motor domain-containing protein	0.0229	0.1065	0.9979
Loa Loa (eye worm)	cathepsin B	0.023	0.1067	0.3093
Entamoeba histolytica	cysteine proteinase, putative	0.0096	0.0291	0.2735
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Brugia malayi	Papain family cysteine protease containing protein	0.0096	0.0291	0.0844
Echinococcus multilocularis	cathepsin L cysteine protease	0.017	0.0718	0.0718
Plasmodium falciparum	kinesin-5	0.0229	0.1065	1
Toxoplasma gondii	cathepsin CPL	0.017	0.0718	0.6733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.012	0.0427	0.4003
Brugia malayi	cathepsin F-like cysteine proteinase	0.005	0.0022	0.0064
Brugia malayi	Cathepsin L-like precursor	0.012	0.0427	0.1238
Schistosoma mansoni	hypothetical protein	0.1536	0.8666	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0639	0.345	0.3981
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0096	0.0291	0.0336
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0639	0.345	1
Onchocerca volvulus	Cathepsin L homolog	0.017	0.0718	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.012	0.0427	0.4003
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Loa Loa (eye worm)	hypothetical protein	0.012	0.0427	0.1238
Trypanosoma cruzi	cysteine protease, putative	0.0096	0.0291	0.0844
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.017	0.0718	0.6747
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0639	0.345	0.3981
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.023	0.1067	0.3093
Plasmodium vivax	vivapain-3	0.0096	0.0291	0.2735
Echinococcus multilocularis	cathepsin b	0.0639	0.345	0.345
Entamoeba histolytica	cysteine proteinase, putative	0.017	0.0718	0.6747
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Schistosoma mansoni	cathepsin F (C01 family)	0.017	0.0718	0.0829
Onchocerca volvulus		0.017	0.0718	1
Trypanosoma cruzi	cruzipain precursor, putative	0.017	0.0718	0.2082
Onchocerca volvulus		0.017	0.0718	1
Entamoeba histolytica	cysteine proteinase, putative	0.0096	0.0291	0.2735
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.0718	0.2082
Schistosoma mansoni	kinesin eg-5	0.0229	0.1065	0.1229
Brugia malayi	Cytochrome P450 family protein	0.0061	0.0084	0.0244
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.0718	0.2082
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0229	0.1065	0.3086
Loa Loa (eye worm)	ctsf protein	0.017	0.0718	0.2082
Echinococcus granulosus	cathepsin b	0.0639	0.345	0.345
Onchocerca volvulus		0.017	0.0718	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.012	0.0427	0.1238
Giardia lamblia	Kinesin-5	0.0229	0.1065	0.9979
Schistosoma mansoni	cathepsin s	0.005	0.0022	0.0025
Plasmodium falciparum	cysteine proteinase falcipain 3	0.017	0.0718	0.6747
Echinococcus granulosus	cathepsin l cysteine peptidase	0.017	0.0718	0.0718
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Brugia malayi	Cathepsin L-like precursor	0.017	0.0718	0.2082
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.0718	0.6733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.0718	0.6733
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Schistosoma mansoni	cathepsin F (C01 family)	0.012	0.0427	0.0493
Brugia malayi	Papain family cysteine protease containing protein	0.0096	0.0291	0.0844
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.0718	0.5506
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.012	0.0427	0.1238
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Loa Loa (eye worm)	hypothetical protein	0.012	0.0427	0.1238
Trypanosoma cruzi	cysteine peptidase, putative	0.0096	0.0291	0.0844
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0639	0.345	0.3981
Echinococcus granulosus	cathepsin L	0.0096	0.0291	0.0291
Brugia malayi	Cathepsin L-like precursor	0.005	0.0022	0.0064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0096	0.0291	0.273
Loa Loa (eye worm)	hypothetical protein	0.012	0.0427	0.1238
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.017	0.0718	0.2082
Onchocerca volvulus	Cathepsin F homolog	0.017	0.0718	1
Onchocerca volvulus		0.017	0.0718	1
Onchocerca volvulus		0.017	0.0718	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.0718	0.2082
Giardia lamblia	Cathepsin B precursor	0.023	0.1067	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Entamoeba histolytica	cysteine proteinase, putative	0.0096	0.0291	0.2735
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.023	0.1067	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0061	0.0084	0.0244
Echinococcus granulosus	cathepsin L cysteine proteinase	0.017	0.0718	0.0718
Onchocerca volvulus		0.017	0.0718	1
Echinococcus multilocularis	kinesin family 1	0.1765	1	1
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Trypanosoma brucei	cysteine peptidase C (CPC)	0.023	0.1067	1
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Giardia lamblia	Cathepsin B precursor	0.023	0.1067	1
Entamoeba histolytica	cysteine protease, putative	0.017	0.0718	0.6747
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.0718	0.6733
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.0718	0.6733
Plasmodium vivax	unspecified product	0.0096	0.0291	0.2735
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.0718	0.5506
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.017	0.0718	0.2082
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Entamoeba histolytica	cysteine proteinase 2	0.0096	0.0291	0.2735
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.0718	0.2082
Brugia malayi	Cathepsin L-like precursor	0.017	0.0718	0.2082
Giardia lamblia	Cathepsin B precursor	0.023	0.1067	1
Echinococcus multilocularis	cathepsin b	0.0639	0.345	0.345
Brugia malayi	Cathepsin L-like precursor	0.017	0.0718	0.2082
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.005	0.0022	0.0064
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.017	0.0718	0.0718
Onchocerca volvulus		0.017	0.0718	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Entamoeba histolytica	cysteine proteinase, putative	0.0096	0.0291	0.2735
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.0718	0.5506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0096	0.0291	0.273
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.0718	0.6733
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.0718	0.6733
Echinococcus multilocularis	cysteine protease	0.017	0.0718	0.0718
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.017	0.0718	0.0718
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Loa Loa (eye worm)	hypothetical protein	0.005	0.0022	0.0064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.017	0.0718	0.6733
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0096	0.0291	0.0844
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.023	0.1067	0.1231
Loa Loa (eye worm)	fibroinase	0.017	0.0718	0.2082
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.0718	0.5506
Echinococcus granulosus	cathepsin l1	0.017	0.0718	0.0718
Plasmodium vivax	unspecified product	0.005	0.0022	0.0206
Entamoeba histolytica	kinesin, putative	0.0229	0.1065	1
Trypanosoma cruzi	cysteine peptidase, putative	0.017	0.0718	0.2082
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0096	0.0291	0.0336
Loa Loa (eye worm)	hypothetical protein	0.005	0.0022	0.0064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Onchocerca volvulus		0.012	0.0427	0.5946
Trypanosoma cruzi	cysteine proteinase, putative	0.0096	0.0291	0.0844
Echinococcus granulosus	cathepsin L cysteine protease	0.0096	0.0291	0.0291
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.0718	0.5506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733
Echinococcus granulosus	cysteine protease	0.0096	0.0291	0.0291
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.0718	0.5506
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.005	0.0022	0.0064
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.0718	0.6733
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Trypanosoma cruzi	cruzipain precursor, putative	0.005	0.0022	0.0064
Echinococcus multilocularis	cathepsin L cysteine protease	0.017	0.0718	0.0718
Entamoeba histolytica	cysteine proteinase, putative	0.017	0.0718	0.6747
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.0718	0.5506
Plasmodium vivax	kinesin-5	0.0229	0.1065	1
Brugia malayi	Papain family cysteine protease containing protein	0.017	0.0718	0.2082
Toxoplasma gondii	cathepsin B	0.023	0.1067	1
Brugia malayi	cathepsin L-like precursor	0.012	0.0427	0.1238
Brugia malayi	Cathepsin L-like precursor	0.017	0.0718	0.2082
Loa Loa (eye worm)	cysteine protease	0.017	0.0718	0.2082
Loa Loa (eye worm)	hypothetical protein	0.005	0.0022	0.0064
Echinococcus granulosus	cathepsin b	0.0639	0.345	0.345
Plasmodium vivax	vivapain-2	0.017	0.0718	0.6747
Schistosoma mansoni	cathepsin F (C01 family)	0.017	0.0718	0.0829
Onchocerca volvulus	Cathepsin L homolog	0.017	0.0718	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.0718	0.5506
Brugia malayi	Cathepsin L-like precursor	0.017	0.0718	0.2082
Trypanosoma cruzi	cysteine peptidase, putative	0.005	0.0022	0.0064
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0639	0.345	0.3981
Brugia malayi	Cathepsin L-like precursor	0.012	0.0427	0.1238
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0096	0.0291	0.0336
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.0718	0.6733
Brugia malayi	Cathepsin L-like precursor	0.017	0.0718	0.2082
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.0718	0.5506
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.0718	0.5506
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0096	0.0291	0.2735
Brugia malayi	cathepsin B-like cysteine proteinase	0.0639	0.345	1
Entamoeba histolytica	cysteine proteinase, putative	0.012	0.0427	0.4012
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.017	0.0718	0.6733
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.017	0.0718	0.5506
Entamoeba histolytica	cysteine proteinase 1, putative	0.0096	0.0291	0.2735
Echinococcus granulosus	cathepsin l1	0.012	0.0427	0.0427
Echinococcus multilocularis	cysteine protease	0.017	0.0718	0.0718
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.017	0.0718	0.6747
Brugia malayi	Kinesin motor domain containing protein	0.0229	0.1065	0.3086
Entamoeba histolytica	cysteine protease, putative	0.0096	0.0291	0.2735
Plasmodium vivax	vivapain-1	0.0096	0.0291	0.2735
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.017	0.0718	0.6733

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 905905