TDR Targets

Basic information

Technical information

TDR Targets ID: 906702
Name: 2-ethoxyethyl 4-[[2-(2-methylphenoxy)acetyl]a mino]benzoate
MW: 357.4 | Formula: C20H23NO5
H donors: 1 H acceptors: 2 LogP: 3.23 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCOCCOC(=O)c1ccc(cc1)NC(=O)COc1ccccc1C
InChi: 1S/C20H23NO5/c1-3-24-12-13-25-20(23)16-8-10-17(11-9-16)21-19(22)14-26-18-7-5-4-6-15(18)2/h4-11H,3,12-14H2,1-2H3,(H,21,22)
InChiKey: SAYJDCAACWEGGF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[[2-(2-methylphenoxy)-1-oxoethyl]amino]benzoic acid 2-ethoxyethyl ester
4-[[2-(2-methylphenoxy)acetyl]amino]benzoic acid 2-ethoxyethyl ester
2-ethoxyethyl 4-[2-(2-methylphenoxy)ethanoylamino]benzoate
ZINC01745382
4-(2-o-Tolyloxy-acetylamino)-benzoic acid 2-ethoxy-ethyl ester
BAS 01392996

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.005	0.0945	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0051	0.0969	0.0995
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0178	0.1836
Echinococcus multilocularis	cysteine protease	0.0027	0.0235	0.0131
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0235	0.0603
Echinococcus multilocularis	geminin	0.0184	0.5087	0.5035
Entamoeba histolytica	Ran family GTPase	0.0023	0.0105	0.4473
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0235	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Echinococcus granulosus	geminin	0.0184	0.5087	0.5087
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0235	0.0603
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0235	0.0603
Echinococcus multilocularis	snurportin 1	0.0335	0.9738	0.9735
Leishmania major	cathepsin L-like protease	0.0027	0.0235	0.1507
Echinococcus multilocularis	cathepsin b	0.0146	0.3903	0.3838
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0361	0.2964
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0235	0.0603
Brugia malayi	cathepsin B-like cysteine proteinase	0.0146	0.3903	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0235	0.0131
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0235	0.1507
Onchocerca volvulus		0.0027	0.0235	0.2491
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0178	0.1836
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0235	0.1507
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0235	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Onchocerca volvulus		0.0027	0.0235	0.2491
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Leishmania major	cathepsin L-like protease	0.0027	0.0235	0.1507
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0105	0.027
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0051	0.0969	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0235	0.243
Leishmania major	cathepsin L-like protease	0.0027	0.0235	0.1507
Schistosoma mansoni	hypothetical protein	0.0184	0.5087	0.5224
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0235	0.243
Echinococcus granulosus	cathepsin l1	0.0027	0.0235	0.0235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Schistosoma mansoni	ran	0.0023	0.0105	0.0108
Brugia malayi	RNA, U transporter 1	0.0089	0.2148	0.5503
Onchocerca volvulus		0.0027	0.0235	0.2491
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0027	0.0235	0.5084
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0146	0.3903	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0235	0.1507
Onchocerca volvulus		0.0027	0.0235	0.2491
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0235	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0235	0.0131
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0235	0.243
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0235	0.1507
Loa Loa (eye worm)	hypothetical protein	0.0146	0.3903	0.4008
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0235	0.0242
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0235	0.1507
Entamoeba histolytica	hypothetical protein	0.0025	0.0178	0.7557
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0235	0.1507
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0235	0.243
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0361	0.0361
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0051	0.0969	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0235	0.1507
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0235	0.0242
Echinococcus granulosus	cathepsin b	0.0146	0.3903	0.3903
Loa Loa (eye worm)	fibroinase	0.0027	0.0235	0.0242
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0105	0.0105
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0235	0.0603
Echinococcus multilocularis	cysteine protease	0.0027	0.0235	0.0131
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0146	0.3903	0.4008
Giardia lamblia	Cathepsin B precursor	0.0051	0.0969	1
Schistosoma mansoni	ran	0.0023	0.0105	0.0108
Schistosoma mansoni	hypothetical protein	0.0184	0.5087	0.5224
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0178	0.1836
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0361	0.2964
Brugia malayi	Importin beta-1 subunit	0.0031	0.0361	0.0925
Leishmania major	cathepsin L-like protease	0.0027	0.0235	0.1507
Onchocerca volvulus		0.0027	0.0235	0.2491
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.0235	0.0242
Leishmania major	cathepsin L-like protease	0.0027	0.0235	0.1507
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0235	0.0242
Plasmodium vivax	vivapain-2	0.0027	0.0235	0.5084
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0146	0.3903	0.4008
Echinococcus granulosus	snurportin 1	0.0335	0.9738	0.9738
Toxoplasma gondii	cathepsin B	0.0051	0.0969	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0178	0.0456
Echinococcus multilocularis	tumor protein p63	0.0344	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0235	0.243
Schistosoma mansoni	hypothetical protein	0.0335	0.9738	1
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0178	0.0841
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0235	0.0603
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0335	0.9738	1
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0105	0.0108
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0027	0.0235	0.5084
Echinococcus multilocularis	cathepsin b	0.0146	0.3903	0.3838
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0235	0.1507
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0235	1
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0361	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0105	0.027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Giardia lamblia	Cathepsin B precursor	0.0051	0.0969	1
Leishmania major	cathepsin L-like protease	0.0027	0.0235	0.1507
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	0.0235	0.0235
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0235	0.0131
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0235	0.243
Leishmania major	cathepsin L-like protease	0.0027	0.0235	0.1507
Echinococcus granulosus	cathepsin b	0.0146	0.3903	0.3903
Plasmodium vivax	vivapain-2	0.0027	0.0235	0.5084
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0105	0.027
Trichomonas vaginalis	ran, putative	0.0023	0.0105	0.1087
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0235	0.0242
Loa Loa (eye worm)	cysteine protease	0.0027	0.0235	0.0242
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0235	0.1507
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Schistosoma mansoni	importin beta-1	0.0031	0.0361	0.0371
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0051	0.0969	0.2482
Giardia lamblia	Cathepsin B precursor	0.0051	0.0969	1
Onchocerca volvulus		0.0027	0.0235	0.2491
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0235	0.1507
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0051	0.0969	1
Toxoplasma gondii	cathepsin CPL	0.0027	0.0235	0.1507
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0235	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0235	0.243
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.0235	0.0603
Loa Loa (eye worm)	hypothetical protein	0.005	0.0945	0.097
Leishmania major	cathepsin L-like protease	0.0027	0.0235	0.1507
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0235	0.2491
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0235	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0361	0.0371
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0235	0.0603
Loa Loa (eye worm)	ctsf protein	0.0027	0.0235	0.0242
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0235	0.0603
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0235	0.0131
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0235	0.0603
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0361	0.0259
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0235	0.243
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0361	0.2964
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0146	0.3903	0.4008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0235	0.243
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0235	0.0603
Leishmania major	cysteine peptidase A (CPA)	0.0027	0.0235	0.1507
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0235	0.2491
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0027	0.0235	0.5084
Onchocerca volvulus		0.0027	0.0235	0.2491
Loa Loa (eye worm)	cathepsin B	0.0051	0.0969	0.0995
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0146	0.3903	0.4008
Onchocerca volvulus	Cathepsin F homolog	0.0027	0.0235	0.2491
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0945	0.097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	0.0235	0.0235
Plasmodium falciparum	importin beta, putative	0.0031	0.0361	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0235	0.1507
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0235	0.243

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 906702