TDR Targets

Basic information

Technical information

TDR Targets ID: 906758
Name: N-(4-bromophenyl)-2-[[3-cyano-4-(3-methoxyphe nyl)-6-oxo-4,5-dihydro-1H-pyridin-2-yl]sulfan yl]acetamide
MW: 472.355 | Formula: C21H18BrN3O3S
H donors: 2 H acceptors: 3 LogP: 3.12 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)C1CC(=O)NC(=C1C#N)SCC(=O)Nc1ccc(cc1)Br
InChi: 1S/C21H18BrN3O3S/c1-28-16-4-2-3-13(9-16)17-10-19(26)25-21(18(17)11-23)29-12-20(27)24-15-7-5-14(22)6-8-15/h2-9,17H,10,12H2,1H3,(H,24,27)(H,25,26)
InChiKey: BXUMSODEFRGRHF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-bromophenyl)-2-[[3-cyano-4-(3-methoxyphenyl)-6-oxo-4,5-dihydro-1H-pyridin-2-yl]thio]acetamide
N-(4-bromophenyl)-2-[[3-cyano-6-keto-4-(3-methoxyphenyl)-4,5-dihydro-1H-pyridin-2-yl]thio]acetamide
N-(4-bromophenyl)-2-[[3-cyano-4-(3-methoxyphenyl)-6-oxo-4,5-dihydro-1H-pyridin-2-yl]sulfanyl]ethanamide
STOCK2S-05658
AE-848/11827101
BAS 00866157
ChemDiv1_001758

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	vivapain-2	0.0188	0.1422	1
Plasmodium vivax	vivapain-2	0.0188	0.1422	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0126	0.0773	0.0773
Trypanosoma cruzi	major cysteine proteinase, putative	0.0059	0.0064	0.0064
Echinococcus granulosus	cathepsin b	0.1006	1	1
Schistosoma mansoni	opsin-like receptor	0.0126	0.0773	0.0773
Echinococcus multilocularis	cathepsin L	0.0111	0.0615	0.0554
Brugia malayi	Cathepsin L-like precursor	0.0188	0.1422	0.1422
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0059	0.0064	0.0064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Echinococcus granulosus	neuropeptides capa receptor	0.0126	0.0773	0.0713
Echinococcus multilocularis	g protein coupled receptor	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.1422	0.3201
Schistosoma mansoni	neuropeptide receptor	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.1422	0.3201
Entamoeba histolytica	cysteine proteinase, putative	0.0136	0.0871	0.5946
Brugia malayi	sulfakinin receptor protein	0.0126	0.0773	0.0773
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0126	0.0773	0.0773
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Giardia lamblia	Cathepsin B precursor	0.0352	0.3137	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Trypanosoma cruzi	cysteine protease, putative	0.0111	0.0615	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Echinococcus multilocularis	serotonin receptor	0.0126	0.0773	0.0713
Onchocerca volvulus		0.0126	0.0773	0.5218
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Brugia malayi	AKH receptor	0.0126	0.0773	0.0773
Schistosoma mansoni	histamine h1 receptor	0.0126	0.0773	0.0773
Brugia malayi	Cathepsin L-like precursor	0.0136	0.0871	0.0871
Echinococcus multilocularis	somatostatin receptor	0.0126	0.0773	0.0713
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.0615	0.4054
Plasmodium vivax	serine-repeat antigen (SERA)	0.0059	0.0064	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0871	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Schistosoma mansoni	amine GPCR	0.0126	0.0773	0.0773
Echinococcus granulosus	neuropeptide s receptor	0.0126	0.0773	0.0713
Brugia malayi	hypothetical protein	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Brugia malayi	Papain family cysteine protease containing protein	0.0059	0.0064	0.0064
Onchocerca volvulus		0.0188	0.1422	1
Echinococcus multilocularis	neuropeptide receptor	0.0126	0.0773	0.0713
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0126	0.0773	0.0773
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.1422	0.4419
Echinococcus multilocularis	g protein coupled receptor	0.0126	0.0773	0.0713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.1422	0.3201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0352	0.3137	0.3137
Brugia malayi	Cathepsin L-like precursor	0.0188	0.1422	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0188	0.1422	0.1422
Brugia malayi	RE15519p	0.0126	0.0773	0.0773
Brugia malayi	cathepsin L-like cysteine proteinase	0.0059	0.0064	0.0064
Brugia malayi	Papain family cysteine protease containing protein	0.0188	0.1422	0.1422
Onchocerca volvulus		0.0126	0.0773	0.5218
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0111	0.0615	0.0615
Onchocerca volvulus		0.0126	0.0773	0.5218
Echinococcus granulosus	neuropeptide Y receptor	0.0126	0.0773	0.0713
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0059	0.0064	0.0451
Echinococcus granulosus	orexin receptor type 2	0.0126	0.0773	0.0713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.1422	0.3201
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0188	0.1422	0.1367
Echinococcus granulosus	neuropeptide receptor	0.0126	0.0773	0.0713
Echinococcus granulosus	cathepsin b	0.1006	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0126	0.0773	0.0773
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0126	0.0773	0.0713
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0059	0.0064	0.0451
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0059	0.0064	0.0451
Brugia malayi	G protein-coupled receptor	0.0126	0.0773	0.0773
Trypanosoma cruzi	cruzipain precursor, putative	0.0188	0.1422	0.1422
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0188	0.1422	0.1422
Echinococcus granulosus	7TM GPCR rhodopsin	0.0126	0.0773	0.0713
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0126	0.0773	0.0773
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.1422	0.4419
Brugia malayi	neuropeptide F receptor	0.0126	0.0773	0.0773
Loa Loa (eye worm)	TYRA-2 protein	0.0126	0.0773	0.0773
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0352	0.3137	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0064	0.0064
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0126	0.0773	0.0713
Onchocerca volvulus	Cathepsin L homolog	0.0188	0.1422	1
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Onchocerca volvulus	Cathepsin F homolog	0.0188	0.1422	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0126	0.0773	0.0773
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.1422	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0059	0.0064	0.0064
Brugia malayi	Serotonin receptor	0.0126	0.0773	0.0773
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0188	0.1422	1
Echinococcus granulosus	cathepsin L	0.0111	0.0615	0.0554
Echinococcus multilocularis	cathepsin b	0.1006	1	1
Onchocerca volvulus		0.0126	0.0773	0.5218
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0126	0.0773	0.0773
Brugia malayi	Dopamine receptor protein 2	0.0126	0.0773	0.0773
Echinococcus granulosus	tm gpcr rhodopsin	0.0126	0.0773	0.0713
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0188	0.1422	0.4419
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0126	0.0773	0.0713
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1006	1	1
Onchocerca volvulus		0.0126	0.0773	0.5218
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0126	0.0773	0.0713
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0126	0.0773	0.0713
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0126	0.0773	0.0773
Echinococcus granulosus	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Echinococcus multilocularis	fmrfamide receptor	0.0126	0.0773	0.0713
Echinococcus granulosus	serotonin receptor	0.0126	0.0773	0.0713
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0126	0.0773	0.0773
Echinococcus granulosus	cathepsin l1	0.0136	0.0871	0.0813
Trypanosoma cruzi	cysteine peptidase, putative	0.0111	0.0615	0.0615
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Onchocerca volvulus		0.0126	0.0773	0.5218
Schistosoma mansoni	neuropeptide F-like receptor	0.0126	0.0773	0.0773
Loa Loa (eye worm)	cysteine protease	0.0188	0.1422	0.1422
Loa Loa (eye worm)	G-protein coupled receptor	0.0126	0.0773	0.0773
Entamoeba histolytica	cysteine proteinase, putative	0.0188	0.1422	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0126	0.0773	0.0773
Echinococcus multilocularis	cathepsin b	0.1006	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0126	0.0773	0.0713
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Entamoeba histolytica	cysteine proteinase, putative	0.0188	0.1422	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.1422	0.4419
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0352	0.3137	0.3137
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0136	0.0871	0.2627
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0059	0.0064	0.0451
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.0615	0.4054
Schistosoma mansoni	opsin-like receptor	0.0126	0.0773	0.0773
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Echinococcus granulosus	neuropeptide receptor	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0871	0.0871
Brugia malayi	Cathepsin L-like precursor	0.0188	0.1422	0.1422
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0059	0.0064	0.0064
Brugia malayi	follicle stimulating hormone receptor	0.0126	0.0773	0.0773
Onchocerca volvulus		0.0126	0.0773	0.5218
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Loa Loa (eye worm)	G-protein coupled receptor	0.0126	0.0773	0.0773
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0126	0.0773	0.0713
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0059	0.0064	0.0451
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0126	0.0773	0.0773
Echinococcus granulosus	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.1422	0.3201
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0126	0.0773	0.0713
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0126	0.0773	0.0773
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.1422	0.3201
Trypanosoma cruzi	cysteine peptidase, putative	0.0188	0.1422	0.1422
Onchocerca volvulus		0.0188	0.1422	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.1422	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Loa Loa (eye worm)	ctsf protein	0.0188	0.1422	0.1422
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0126	0.0773	0.0773
Echinococcus multilocularis	cathepsin L cysteine protease	0.0188	0.1422	0.1367
Echinococcus multilocularis	serotonin receptor	0.0126	0.0773	0.0713
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0188	0.1422	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0126	0.0773	0.0713
Loa Loa (eye worm)	neuropeptide F receptor	0.0126	0.0773	0.0773
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0126	0.0773	0.0773
Echinococcus granulosus	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0059	0.0064	0.0064
Schistosoma mansoni	biogenic amine receptor	0.0126	0.0773	0.0773
Brugia malayi	putative neuropeptide receptor NPR1	0.0126	0.0773	0.0773
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0126	0.0773	0.5218
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0188	0.1422	0.1367
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0126	0.0773	0.0713
Schistosoma mansoni	biogenic amine receptor	0.0126	0.0773	0.0773
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.1422	0.4419
Brugia malayi	G-protein coupled receptor	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0188	0.1422	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0126	0.0773	0.0713
Onchocerca volvulus		0.0126	0.0773	0.5218
Trypanosoma cruzi	cysteine peptidase, putative	0.0188	0.1422	0.1422
Brugia malayi	hypothetical protein	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0064	0.0064
Onchocerca volvulus		0.0126	0.0773	0.5218
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0126	0.0773	0.0713
Onchocerca volvulus		0.0188	0.1422	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0064	0.0064
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Schistosoma mansoni	opsin-like receptor	0.0126	0.0773	0.0773
Echinococcus multilocularis	cathepsin L cysteine protease	0.0188	0.1422	0.1367
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Echinococcus granulosus	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0059	0.0064	0.0064
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0126	0.0773	0.0713
Giardia lamblia	Cathepsin B precursor	0.0352	0.3137	1
Echinococcus granulosus	g protein coupled receptor	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0059	0.0064	0.0451
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0615	0.1791
Schistosoma mansoni	amine GPCR	0.0126	0.0773	0.0773
Echinococcus granulosus	cathepsin L cysteine protease	0.0111	0.0615	0.0554
Schistosoma mansoni	biogenic amine receptor	0.0126	0.0773	0.0773
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0126	0.0773	0.0773
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Echinococcus multilocularis	neuropeptide receptor A26	0.0126	0.0773	0.0713
Trypanosoma cruzi	cysteine proteinase, putative	0.0111	0.0615	0.0615
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0126	0.0773	0.0773
Schistosoma mansoni	cathepsin S (C01 family)	0.0059	0.0064	0.0064
Echinococcus multilocularis	neuropeptide receptor	0.0126	0.0773	0.0713
Onchocerca volvulus		0.0126	0.0773	0.5218
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Trypanosoma cruzi	cysteine peptidase, putative	0.0188	0.1422	0.1422
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1006	1	1
Brugia malayi	Cathepsin L-like precursor	0.0188	0.1422	0.1422
Brugia malayi	hypothetical protein	0.0126	0.0773	0.0773
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0126	0.0773	0.0713
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Loa Loa (eye worm)	hypothetical protein	0.1006	1	1
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Brugia malayi	Papain family cysteine protease containing protein	0.0111	0.0615	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Echinococcus granulosus	7tm_1 domain containing protein	0.0126	0.0773	0.0713
Onchocerca volvulus		0.0188	0.1422	1
Plasmodium vivax	unspecified product	0.0111	0.0615	0.4322
Echinococcus granulosus	G protein coupled receptor 139	0.0126	0.0773	0.0713
Echinococcus granulosus	fmrfamide receptor	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.1422	0.4419
Plasmodium vivax	vivapain-3	0.0111	0.0615	0.4322
Echinococcus granulosus	sex peptide receptor	0.0126	0.0773	0.0713
Onchocerca volvulus		0.0188	0.1422	1
Toxoplasma gondii	cathepsin B	0.0352	0.3137	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0059	0.0064	0.0451
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0126	0.0773	0.0773
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0188	0.1422	0.1422
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0188	0.1422	0.4419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0136	0.0871	0.0871
Schistosoma mansoni	cathepsin F (C01 family)	0.0188	0.1422	0.1422
Brugia malayi	hypothetical protein	0.0126	0.0773	0.0773
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0126	0.0773	0.0773
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0126	0.0773	0.0713
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.0615	0.4054
Brugia malayi	hypothetical protein	0.0126	0.0773	0.0773
Entamoeba histolytica	cysteine proteinase 2	0.0111	0.0615	0.4054
Schistosoma mansoni	hypothetical protein	0.0126	0.0773	0.0773
Echinococcus granulosus	allatostatin A receptor	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0059	0.0064	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0064	0.0064
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0059	0.0064	0.0064
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0111	0.0615	0.4054
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0126	0.0773	0.0713
Brugia malayi	Melatonin receptor type 1A	0.0126	0.0773	0.0773
Onchocerca volvulus		0.0126	0.0773	0.5218
Brugia malayi	hypothetical protein	0.0126	0.0773	0.0773
Loa Loa (eye worm)	cathepsin B	0.0352	0.3137	0.3137
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0136	0.0871	0.0871
Trypanosoma cruzi	cysteine peptidase, putative	0.0188	0.1422	0.1422
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0059	0.0064	0.0451
Onchocerca volvulus		0.0126	0.0773	0.5218
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Echinococcus multilocularis	neuropeptides capa receptor	0.0126	0.0773	0.0713
Brugia malayi	hypothetical protein	0.0126	0.0773	0.0773
Brugia malayi	Dopamine receptor protein 1	0.0126	0.0773	0.0773
Brugia malayi	Cathepsin L-like precursor	0.0136	0.0871	0.0871
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0111	0.0615	0.0615
Schistosoma mansoni	hypothetical protein	0.0126	0.0773	0.0773
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0059	0.0064	0.0064
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0126	0.0773	0.0773
Echinococcus multilocularis	neuropeptide s receptor	0.0126	0.0773	0.0713
Echinococcus multilocularis	neuropeptides capa receptor	0.0126	0.0773	0.0713
Schistosoma mansoni	amine GPCR	0.0126	0.0773	0.0773
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0126	0.0773	0.0713
Schistosoma mansoni	amine GPCR	0.0126	0.0773	0.0773
Schistosoma mansoni	amine GPCR	0.0126	0.0773	0.0773
Echinococcus granulosus	cysteine protease	0.0111	0.0615	0.0554
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0126	0.0773	0.0713
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0059	0.0064	0.0064
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0126	0.0773	0.0773
Echinococcus granulosus	neuropeptides capa receptor	0.0126	0.0773	0.0713
Echinococcus multilocularis	neuropeptide Y receptor	0.0126	0.0773	0.0713
Entamoeba histolytica	cysteine protease, putative	0.0188	0.1422	1
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0871	0.0871
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0059	0.0064	0.0064
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0111	0.0615	0.0615
Schistosoma mansoni	cathepsin F (C01 family)	0.0136	0.0871	0.0871
Brugia malayi	larval opioid receptor	0.0126	0.0773	0.0773
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0111	0.0615	0.0615
Schistosoma mansoni	growth hormone secretagogue receptor	0.0126	0.0773	0.0773
Onchocerca volvulus		0.0126	0.0773	0.5218
Schistosoma mansoni	cathepsin F (C01 family)	0.0188	0.1422	0.1422
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0126	0.0773	0.0773
Entamoeba histolytica	cysteine proteinase 1, putative	0.0111	0.0615	0.4054
Brugia malayi	neuropeptide F receptor	0.0126	0.0773	0.0773
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.1422	0.4419
Brugia malayi	hypothetical protein	0.0126	0.0773	0.0773
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0126	0.0773	0.0773
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0126	0.0773	0.0773
Echinococcus multilocularis	orexin receptor type 2	0.0126	0.0773	0.0713
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1006	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0126	0.0773	0.0713
Brugia malayi	fibroinase precursor	0.0059	0.0064	0.0064
Brugia malayi	G protein-coupled receptor F59B2.13	0.0126	0.0773	0.0773
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Plasmodium vivax	unspecified product	0.0059	0.0064	0.0451
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Echinococcus granulosus	dro:myosuppressin receptor	0.0126	0.0773	0.0713
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.1422	0.3201
Brugia malayi	Dopamine receptor	0.0126	0.0773	0.0773
Schistosoma mansoni	neuropeptide f receptor 76f	0.0126	0.0773	0.0773
Brugia malayi	cathepsin L precursor	0.0059	0.0064	0.0064
Toxoplasma gondii	cathepsin CPL	0.0188	0.1422	0.4419
Trypanosoma cruzi	cysteine proteinase, putative	0.0111	0.0615	0.0615
Echinococcus granulosus	biogenic amine 5HT receptor	0.0126	0.0773	0.0713
Schistosoma mansoni	neuropeptide receptor	0.0126	0.0773	0.0773
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0059	0.0064	0.0064
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.1422	0.3201
Echinococcus multilocularis	cysteine protease	0.0188	0.1422	0.1367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Loa Loa (eye worm)	neuropeptide F receptor	0.0126	0.0773	0.0773
Brugia malayi	ORL1-like opioid receptor	0.0126	0.0773	0.0773
Echinococcus multilocularis	dro:myosuppressin receptor	0.0126	0.0773	0.0713
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.1422	0.4419
Plasmodium vivax	vivapain-1	0.0111	0.0615	0.4322
Schistosoma mansoni	cathepsin C	0.0059	0.0064	0.0064
Echinococcus granulosus	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Onchocerca volvulus		0.0126	0.0773	0.5218
Schistosoma mansoni	neuropeptide F-like receptor	0.0126	0.0773	0.0773
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0126	0.0773	0.5218
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0352	0.3137	1
Echinococcus multilocularis	g protein coupled receptor	0.0126	0.0773	0.0713
Entamoeba histolytica	cysteine proteinase, putative	0.0111	0.0615	0.4054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Schistosoma mansoni	hypothetical protein	0.0126	0.0773	0.0773
Loa Loa (eye worm)	melatonin receptor type 1A	0.0126	0.0773	0.0773
Echinococcus granulosus	g protein coupled receptor	0.0126	0.0773	0.0713
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0126	0.0773	0.0713
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0126	0.0773	0.0713
Echinococcus multilocularis	fmrfamide receptor	0.0126	0.0773	0.0713
Onchocerca volvulus		0.0126	0.0773	0.5218
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0059	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.1422	0.3201
Echinococcus granulosus	g-protein coupled receptor	0.0126	0.0773	0.0713
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0059	0.0064	0.0064
Brugia malayi	Serotonin receptor	0.0126	0.0773	0.0773
Brugia malayi	Papain family cysteine protease containing protein	0.0059	0.0064	0.0064
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Echinococcus granulosus	tm gpcr rhodopsin	0.0126	0.0773	0.0713
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Echinococcus granulosus	hypothetical protein	0.0126	0.0773	0.0713
Onchocerca volvulus		0.0126	0.0773	0.5218
Loa Loa (eye worm)	fibroinase	0.0188	0.1422	0.1422
Brugia malayi	Cathepsin L-like precursor	0.0188	0.1422	0.1422
Echinococcus granulosus	tm gpcr rhodopsin	0.0126	0.0773	0.0713
Brugia malayi	Papain family cysteine protease containing protein	0.0111	0.0615	0.0615
Schistosoma mansoni	myosin xvIII	0.0126	0.0773	0.0773
Brugia malayi	putative neuropeptide receptor	0.0126	0.0773	0.0773
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0111	0.0615	0.1791
Echinococcus granulosus	neuropeptide receptor A26	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Brugia malayi	cathepsin L-like precursor	0.0136	0.0871	0.0871
Brugia malayi	G-protein coupled receptor	0.0126	0.0773	0.0773
Schistosoma mansoni	cathepsin B (C01 family)	0.0059	0.0064	0.0064
Schistosoma mansoni	neuropeptide receptor	0.0126	0.0773	0.0773
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0059	0.0064	0.0451
Onchocerca volvulus		0.0188	0.1422	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0059	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0126	0.0773	0.0713
Echinococcus multilocularis	cysteine protease	0.0188	0.1422	0.1367
Echinococcus granulosus	somatostatin receptor	0.0126	0.0773	0.0713
Schistosoma mansoni	adenoreceptor	0.0126	0.0773	0.0773
Echinococcus multilocularis	G protein coupled receptor 139	0.0126	0.0773	0.0713
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0126	0.0773	0.0773
Echinococcus granulosus	g protein coupled receptor	0.0126	0.0773	0.0713
Onchocerca volvulus		0.0188	0.1422	1
Schistosoma mansoni	neuropeptide receptor	0.0126	0.0773	0.0773
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0188	0.1422	0.1367
Echinococcus granulosus	cathepsin l1	0.0188	0.1422	0.1367
Echinococcus multilocularis	g-protein coupled receptor	0.0126	0.0773	0.0713
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0059	0.0064	0.0064
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0126	0.0773	0.0713
Onchocerca volvulus	Cathepsin L homolog	0.0188	0.1422	1
Onchocerca volvulus		0.0126	0.0773	0.5218
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Brugia malayi	GnHR receptor homolog	0.0126	0.0773	0.0773
Brugia malayi	hypothetical protein	0.0126	0.0773	0.0773
Brugia malayi	Papain family cysteine protease containing protein	0.0059	0.0064	0.0064
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0126	0.0773	0.0773
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1006	1	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0126	0.0773	0.0773
Brugia malayi	cathepsin F-like cysteine proteinase	0.0059	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0064	0.0064
Brugia malayi	hypothetical protein	0.0126	0.0773	0.0773
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1006	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0188	0.1422	0.4419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0188	0.1422	0.4419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.1422	0.3201
Schistosoma mansoni	hypothetical protein	0.0126	0.0773	0.0773
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0188	0.1422	0.1367
Echinococcus multilocularis	sex peptide receptor	0.0126	0.0773	0.0713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0136	0.0871	0.2627
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0126	0.0773	0.0773
Giardia lamblia	Cathepsin B precursor	0.0352	0.3137	1
Onchocerca volvulus		0.0136	0.0871	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0111	0.0615	0.4054
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0126	0.0773	0.0773
Plasmodium vivax	serine-repeat antigen (SERA)	0.0059	0.0064	0.0451
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0352	0.3137	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0059	0.0064	0.0064
Echinococcus granulosus	neuropeptide FF receptor 2	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Echinococcus multilocularis	allatostatin A receptor	0.0126	0.0773	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0126	0.0773	0.0773
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0126	0.0773	0.0713
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0188	0.1422	0.1422
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0059	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0773	0.0773

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 906758