TDR Targets

Basic information

Technical information

TDR Targets ID: 906775
Name: (4Z)-4-[(2-chlorophenyl)methylidene]-2-(5-met hyl-2-nitrophenyl)-1,3-oxazol-5-one
MW: 342.733 | Formula: C17H11ClN2O4
H donors: 0 H acceptors: 3 LogP: 4.38 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(c(c1)C1=NC(=Cc2ccccc2Cl)C(=O)O1)[N+](=O)[O-]
InChi: 1S/C17H11ClN2O4/c1-10-6-7-15(20(22)23)12(8-10)16-19-14(17(21)24-16)9-11-4-2-3-5-13(11)18/h2-9H,1H3/b14-9-
InChiKey: MGOPXFMHSDTXRQ-ZROIWOOFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4Z)-4-[(2-chlorophenyl)methylene]-2-(5-methyl-2-nitro-phenyl)oxazol-5-one
(4Z)-4-[(2-chlorophenyl)methylene]-2-(5-methyl-2-nitrophenyl)-5-oxazolone
(4Z)-4-(2-chlorobenzylidene)-2-(5-methyl-2-nitro-phenyl)oxazol-5-one
(4Z)-4-[(2-chlorophenyl)methylidene]-2-(5-methyl-2-nitro-phenyl)-1,3-oxazol-5-one
ZINC00178471

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0307	0.0634	0.1951
Brugia malayi	Papain family cysteine protease containing protein	0.0304	0.0622	0.0592
Trypanosoma cruzi	major cysteine proteinase, putative	0.0238	0.0354	0.0323
Echinococcus granulosus	cathepsin b	0.2629	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0373	0.0898	0.0868
Echinococcus granulosus	cathepsin L	0.0304	0.0622	0.0592
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0519	0.1488	0.4722
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0599	0.181	0.4763
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0599	0.181	0.4763
Entamoeba histolytica	cysteine proteinase 2	0.0304	0.0622	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Echinococcus multilocularis	cathepsin b	0.2629	1	1
Echinococcus multilocularis	cysteine protease	0.0519	0.1488	0.146
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2629	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0304	0.0622	0.0592
Echinococcus multilocularis	cathepsin b	0.2629	1	1
Echinococcus granulosus	cathepsin l1	0.0519	0.1488	0.146
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.0519	0.1488	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0519	0.1488	0.4722
Echinococcus granulosus	cathepsin L cysteine protease	0.0304	0.0622	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0373	0.0898	0.0868
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Schistosoma mansoni	cathepsin F (C01 family)	0.0519	0.1488	0.146
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0922	0.3115	0.3093
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0519	0.1488	0.146
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0304	0.0622	0.1914
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0519	0.1488	0.146
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.2629	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0519	0.1488	0.146
Onchocerca volvulus		0.0519	0.1488	1
Plasmodium vivax	vivapain-1	0.0304	0.0622	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0599	0.181	0.4763
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0519	0.1488	1
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0519	0.1488	0.146
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0922	0.3115	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0852	0.2833	0.281
Onchocerca volvulus		0.0519	0.1488	1
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0304	0.0622	0.0592
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.015	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0519	0.1488	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0304	0.0622	0.4054
Brugia malayi	cathepsin L-like precursor	0.0373	0.0898	0.0868
Onchocerca volvulus	Cathepsin L homolog	0.0519	0.1488	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0304	0.0622	0.1914
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0922	0.3115	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0307	0.0634	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0373	0.0898	0.0868
Toxoplasma gondii	cathepsin CPL	0.0519	0.1488	0.4722
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0307	0.0634	0.1951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0519	0.1488	0.4722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.015	0	0.5
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0452	0.122	0.1191
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.015	0	0.5
Giardia lamblia	Cathepsin B precursor	0.0922	0.3115	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0304	0.0622	0.0592
Trypanosoma cruzi	cysteine peptidase, putative	0.0599	0.181	0.1783
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0519	0.1488	0.4722
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0307	0.0634	0.1951
Trypanosoma cruzi	cysteine protease, putative	0.0304	0.0622	0.0592
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0922	0.3115	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0519	0.1488	1
Loa Loa (eye worm)	hypothetical protein	0.0373	0.0898	0.0868
Trypanosoma cruzi	cysteine peptidase, putative	0.0599	0.181	0.1783
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0307	0.0634	0.1951
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0519	0.1488	0.4722
Onchocerca volvulus		0.0373	0.0898	0.5946
Loa Loa (eye worm)	ctsf protein	0.0519	0.1488	0.146
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0304	0.0622	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0519	0.1488	0.146
Trypanosoma cruzi	cysteine peptidase, putative	0.0519	0.1488	0.146
Onchocerca volvulus		0.0519	0.1488	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0519	0.1488	0.4722
Entamoeba histolytica	cysteine proteinase, putative	0.0304	0.0622	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Onchocerca volvulus		0.0519	0.1488	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Leishmania major	cathepsin L-like protease	0.0599	0.181	0.1977
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0599	0.181	0.4763
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Echinococcus granulosus	cathepsin b	0.2629	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0304	0.0622	0.0592
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2629	1	1
Echinococcus granulosus	cysteine protease	0.0304	0.0622	0.0592
Onchocerca volvulus		0.0519	0.1488	1
Echinococcus multilocularis	cysteine protease	0.0519	0.1488	0.146
Trypanosoma cruzi	cruzipain precursor, putative	0.0599	0.181	0.1783
Loa Loa (eye worm)	hypothetical protein	0.2629	1	1
Giardia lamblia	Cathepsin B precursor	0.0922	0.3115	1
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0373	0.0898	0.0868
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0307	0.0634	0.1951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0599	0.181	0.4763
Entamoeba histolytica	cysteine proteinase, putative	0.0519	0.1488	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0304	0.0622	0.0592
Trypanosoma cruzi	cysteine peptidase, putative	0.0599	0.181	0.1783
Plasmodium vivax	vivapain-2	0.0519	0.1488	1
Brugia malayi	Cathepsin L-like precursor	0.0373	0.0898	0.0868
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0519	0.1488	0.146
Giardia lamblia	Cathepsin B precursor	0.0922	0.3115	1
Plasmodium vivax	vivapain-3	0.0304	0.0622	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0304	0.0622	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2629	1	1
Echinococcus multilocularis	cathepsin L	0.0304	0.0622	0.0592
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.2629	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0304	0.0622	0.0592
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0304	0.0622	0.0592
Onchocerca volvulus		0.0519	0.1488	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0304	0.0622	0.0592
Toxoplasma gondii	cathepsin B	0.0922	0.3115	1
Echinococcus granulosus	cathepsin l1	0.0373	0.0898	0.0868
Brugia malayi	Cathepsin L-like precursor	0.0519	0.1488	0.146
Echinococcus multilocularis	cathepsin L cysteine protease	0.0519	0.1488	0.146
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0519	0.1488	0.4722
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0307	0.0634	0.1951
Leishmania major	cathepsin L-like protease	0.0599	0.181	0.1977
Plasmodium vivax	unspecified product	0.0304	0.0622	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0599	0.181	0.4763
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0519	0.1488	0.146
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0373	0.0898	0.2808
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0519	0.1488	0.146
Brugia malayi	Papain family cysteine protease containing protein	0.0519	0.1488	0.146
Onchocerca volvulus	Cathepsin F homolog	0.0519	0.1488	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0599	0.181	0.4763
Plasmodium vivax	vivapain-2	0.0519	0.1488	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0307	0.0634	0.4133
Entamoeba histolytica	cysteine proteinase, putative	0.0373	0.0898	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0599	0.181	0.4763
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0599	0.181	0.4763
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Treponema pallidum	fructose-bisphosphate aldolase	0.0307	0.0634	0.5
Loa Loa (eye worm)	cysteine protease	0.0519	0.1488	0.146
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0599	0.181	0.4763
Loa Loa (eye worm)	fibroinase	0.0519	0.1488	0.146
Onchocerca volvulus		0.0519	0.1488	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0519	0.1488	0.4722
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0519	0.1488	0.4722
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0307	0.0634	0.1951
Entamoeba histolytica	cysteine proteinase, putative	0.0304	0.0622	0.4054
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0519	0.1488	0.146
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0519	0.1488	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0519	0.1488	0.146
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0519	0.1488	0.146
Entamoeba histolytica	cysteine proteinase, putative	0.0304	0.0622	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0373	0.0898	0.0868
Loa Loa (eye worm)	cathepsin B	0.0922	0.3115	0.3093
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0519	0.1488	0.4722
Entamoeba histolytica	cysteine protease, putative	0.0304	0.0622	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0373	0.0898	0.2808
Entamoeba histolytica	cysteine proteinase, putative	0.0519	0.1488	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0307	0.0634	0.4133
Giardia lamblia	Fructose-bisphosphate aldolase	0.0307	0.0634	0.1951
Loa Loa (eye worm)	hypothetical protein	0.0519	0.1488	0.146
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0922	0.3115	0.3093
Brugia malayi	Cathepsin L-like precursor	0.0519	0.1488	0.146
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0599	0.181	0.4763
Schistosoma mansoni	cathepsin F (C01 family)	0.0519	0.1488	0.146
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0519	0.1488	0.4722
Leishmania major	cathepsin L-like protease	0.0599	0.181	0.1977
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0519	0.1488	0.4722

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 906775