Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | cathepsin L-like precursor | 0.0143 | 0.1329 | 0.1329 |
Loa Loa (eye worm) | fibroinase | 0.0209 | 0.4176 | 0.3437 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.4176 | 1 |
Plasmodium vivax | vivapain-2 | 0.0209 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.4176 | 0.3437 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0143 | 0.1329 | 0.1329 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.4176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 1 | 1 |
Onchocerca volvulus | 0.0209 | 0.4176 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0209 | 0.4176 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0209 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0143 | 0.1329 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.0143 | 0.1329 | 0.1329 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0209 | 0.4176 | 0.4176 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.4176 | 0.4176 |
Onchocerca volvulus | 0.0209 | 0.4176 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0209 | 0.4176 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0209 | 0.4176 | 0.4176 |
Leishmania major | cathepsin L-like protease | 0.0209 | 0.4176 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.4176 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0138 | 0.1126 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Echinococcus granulosus | cathepsin b | 0.0344 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0344 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.4176 | 0.4176 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0344 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0344 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0143 | 0.1329 | 0.1329 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0209 | 0.4176 | 0.4176 |
Onchocerca volvulus | 0.0209 | 0.4176 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.4176 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0209 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.4176 | 0.4176 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0143 | 0.1329 | 0.3182 |
Echinococcus multilocularis | cathepsin b | 0.0344 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0138 | 0.1126 | 0.1126 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0209 | 0.4176 | 0.4176 |
Entamoeba histolytica | cysteine protease, putative | 0.0209 | 0.4176 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0138 | 0.1126 | 0.1126 |
Leishmania major | cysteine peptidase A (CPA) | 0.0209 | 0.4176 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0344 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.4176 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0209 | 0.4176 | 1 |
Onchocerca volvulus | 0.0209 | 0.4176 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0344 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0344 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0209 | 0.4176 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0209 | 0.4176 | 1 |
Onchocerca volvulus | 0.0209 | 0.4176 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0209 | 0.4176 | 0.4176 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0209 | 0.4176 | 0.3437 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0209 | 0.4176 | 0.4176 |
Echinococcus granulosus | cathepsin l1 | 0.0143 | 0.1329 | 0.1329 |
Echinococcus granulosus | cathepsin b | 0.0344 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0209 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0143 | 0.1329 | 0.1329 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0209 | 0.4176 | 0.4176 |
Onchocerca volvulus | 0.0209 | 0.4176 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0209 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0209 | 0.4176 | 0.3437 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.4176 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.4176 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0209 | 0.4176 | 0.4176 |
Leishmania major | cathepsin L-like protease | 0.0209 | 0.4176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1329 | 0.0228 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0209 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1329 | 0.0228 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0209 | 0.4176 | 0.3437 |
Onchocerca volvulus | Cathepsin L homolog | 0.0209 | 0.4176 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0138 | 0.1126 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0209 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0209 | 0.4176 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0209 | 0.4176 | 0.4176 |
Leishmania major | cathepsin L-like protease | 0.0209 | 0.4176 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0209 | 0.4176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1329 | 0.0228 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0209 | 0.4176 | 0.4176 |
Leishmania major | cathepsin L-like protease | 0.0209 | 0.4176 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0209 | 0.4176 | 0.4176 |
Onchocerca volvulus | Cathepsin F homolog | 0.0209 | 0.4176 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0209 | 0.4176 | 0.4176 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Onchocerca volvulus | 0.0209 | 0.4176 | 1 | |
Loa Loa (eye worm) | cysteine protease | 0.0209 | 0.4176 | 0.3437 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0143 | 0.1329 | 0.1329 |
Onchocerca volvulus | Cathepsin L homolog | 0.0209 | 0.4176 | 1 |
Leishmania major | cathepsin L-like protease | 0.0209 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0143 | 0.1329 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.4176 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0209 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0209 | 0.4176 | 0.4176 |
Giardia lamblia | Cathepsin B precursor | 0.0138 | 0.1126 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.4176 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.4176 | 0.4176 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.4176 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0138 | 0.1126 | 0.2697 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0138 | 0.1126 | 0.2697 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.4176 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.