Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative titin | 0.0047 | 0.1159 | 1 |
Trichomonas vaginalis | NADH dehydrogenase 51 kDa subunit, putative | 0.0033 | 0.0691 | 1 |
Toxoplasma gondii | GDA1/CD39 (nucleoside phosphatase) family protein | 0.003 | 0.0615 | 0.89 |
Echinococcus granulosus | hemicentin 1 | 0.0047 | 0.1159 | 0.1159 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1159 | 0.0579 |
Leishmania major | adenylate kinase, putative | 0.0023 | 0.0381 | 0.5511 |
Brugia malayi | hypothetical protein | 0.0047 | 0.1159 | 1 |
Plasmodium falciparum | apyrase, putative | 0.0323 | 1 | 1 |
Schistosoma mansoni | ATP-diphosphohydrolase 1 | 0.0323 | 1 | 1 |
Giardia lamblia | Adenylate kinase | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0323 | 1 | 1 |
Echinococcus multilocularis | low density lipoprotein receptor (ldl) | 0.0047 | 0.1159 | 0.1159 |
Trypanosoma cruzi | adenylate kinase, putative | 0.0033 | 0.0691 | 1 |
Toxoplasma gondii | GDA1/CD39 (nucleoside phosphatase) family protein | 0.003 | 0.0615 | 0.89 |
Trypanosoma cruzi | adenylate kinase, putative | 0.0023 | 0.0381 | 0.5511 |
Schistosoma mansoni | adenylate kinase | 0.0033 | 0.0691 | 0.0081 |
Plasmodium vivax | adenylate kinase 2, putative | 0.0033 | 0.0691 | 1 |
Wolbachia endosymbiont of Brugia malayi | adenylate kinase | 0.0011 | 0 | 0.5 |
Plasmodium falciparum | adenylate kinase | 0.0033 | 0.0691 | 0.0081 |
Leishmania major | nucleoside phosphatase, putative,guanosine diphosphatase, putative | 0.003 | 0.0615 | 0.89 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0323 | 1 | 1 |
Onchocerca volvulus | 0.0047 | 0.1159 | 1 | |
Echinococcus granulosus | low density lipoprotein receptor ldl | 0.0047 | 0.1159 | 0.1159 |
Echinococcus granulosus | adenylate kinase 2 mitochondrial | 0.0033 | 0.0691 | 0.0691 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0615 | 0.5311 |
Onchocerca volvulus | 0.0047 | 0.1159 | 1 | |
Trypanosoma cruzi | nucleoside phosphatase, putative | 0.003 | 0.0615 | 0.89 |
Echinococcus granulosus | 3'partial|ectonucleoside triphosphate diphosphohydrolase | 0.003 | 0.0615 | 0.0615 |
Trypanosoma brucei | nucleoside diphosphatase, putative | 0.003 | 0.0615 | 0.89 |
Leishmania major | adenylate kinase, putative | 0.0033 | 0.0691 | 1 |
Toxoplasma gondii | Nucleoside-diphosphatase | 0.003 | 0.0615 | 0.89 |
Brugia malayi | Nucleoside-diphosphatase mig-23 | 0.003 | 0.0615 | 0.5311 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0047 | 0.1159 | 1 |
Treponema pallidum | adenylate kinase (adk) | 0.0033 | 0.0691 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1159 | 1 |
Entamoeba histolytica | adenylate kinase | 0.0011 | 0 | 0.5 |
Chlamydia trachomatis | adenylate kinase | 0.0011 | 0 | 0.5 |
Trypanosoma brucei | adenylate kinase, putative | 0.0023 | 0.0381 | 0.5511 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.003 | 0.0615 | 0.0615 |
Schistosoma mansoni | titin | 0.0047 | 0.1159 | 0.0579 |
Schistosoma mansoni | adenylate kinase | 0.0069 | 0.1866 | 0.1333 |
Echinococcus granulosus | ectonucleoside triphosphate diphosphohydrolase | 0.003 | 0.0615 | 0.0615 |
Toxoplasma gondii | GDA1/CD39 (nucleoside phosphatase) family protein | 0.003 | 0.0615 | 0.89 |
Schistosoma mansoni | adenylate kinase | 0.0033 | 0.0691 | 0.0081 |
Toxoplasma gondii | NTPase II | 0.003 | 0.0615 | 0.89 |
Echinococcus multilocularis | hemicentin 1 | 0.0047 | 0.1159 | 0.1159 |
Onchocerca volvulus | 0.0047 | 0.1159 | 1 | |
Trypanosoma cruzi | adenylate kinase 2 | 0.0023 | 0.0381 | 0.5511 |
Echinococcus multilocularis | ectonucleoside triphosphate diphosphohydrolase | 0.0323 | 1 | 1 |
Toxoplasma gondii | adenylate kinase, putative | 0.0033 | 0.0691 | 1 |
Trypanosoma brucei | nucleoside phosphatase, putative | 0.003 | 0.0615 | 0.89 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0047 | 0.1159 | 1 |
Echinococcus granulosus | contactin | 0.0047 | 0.1159 | 0.1159 |
Leishmania major | ATP diphosphohydrolase | 0.003 | 0.0615 | 0.89 |
Onchocerca volvulus | Netrin receptor homolog | 0.0047 | 0.1159 | 1 |
Mycobacterium ulcerans | adenylate kinase | 0.0011 | 0 | 0.5 |
Leishmania major | adenylate kinase 2 | 0.0023 | 0.0381 | 0.5511 |
Trypanosoma cruzi | nucleoside phosphatase, putative | 0.003 | 0.0615 | 0.89 |
Echinococcus multilocularis | adenylate kinase 2, mitochondrial | 0.0033 | 0.0691 | 0.0691 |
Trypanosoma cruzi | adenylate kinase, putative | 0.0033 | 0.0691 | 1 |
Mycobacterium leprae | PROBABLE ADENYLATE KINASE KAD (ATP-AMP TRANSPHOSPHORYLASE) | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | low-density lipoprotein receptor (ldl) | 0.0047 | 0.1159 | 0.0579 |
Onchocerca volvulus | 0.0047 | 0.1159 | 1 | |
Trichomonas vaginalis | NADH dehydrogenase 51 kDa subunit, putative | 0.0033 | 0.0691 | 1 |
Trypanosoma brucei | adenylate kinase, putative | 0.0033 | 0.0691 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.