Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.4386 | 0.8342 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0189 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.4386 | 0.8342 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.4386 | 0.8342 |
Brugia malayi | glutathione reductase | 0.0048 | 0.0109 | 0.0109 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.4386 | 0.8342 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.0109 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.0109 | 0.0109 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.5236 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.007 | 0.169 | 0.1599 |
Leishmania major | 0.0189 | 1 | 1 | |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.0109 | 0.0109 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.007 | 0.169 | 0.1599 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.5236 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.5236 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.0109 | 0.0109 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0189 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0189 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0189 | 1 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.4386 | 0.8342 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0189 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.007 | 0.169 | 0.1599 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.0109 | 0.5 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.007 | 0.169 | 0.1599 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.0109 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.0109 | 0.0109 |
Toxoplasma gondii | fructose-bisphospatase I | 0.007 | 0.169 | 0.1599 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.0109 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0189 | 1 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.4386 | 0.8342 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.5236 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 995 nM | Inhibition of human liver recombinant FBPase | ChEMBL. | 20045638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.