Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.007 | 0.169 | 0.1599 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.0109 | 0.0109 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0189 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0048 | 0.0109 | 0.0109 |
Toxoplasma gondii | fructose-bisphospatase I | 0.007 | 0.169 | 0.1599 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.0109 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.4386 | 0.8342 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.0109 | 0.0109 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0189 | 1 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.4386 | 0.8342 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.0109 | 0.0109 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.0109 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.0109 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.4386 | 0.8342 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.007 | 0.169 | 0.1599 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0121 | 0.5236 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0121 | 0.5236 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0121 | 0.5236 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.4386 | 0.8342 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.0109 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0189 | 1 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.4386 | 0.8342 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.007 | 0.169 | 0.1599 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0121 | 0.5236 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0189 | 1 | 1 |
Leishmania major | 0.0189 | 1 | 1 | |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 1 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.4386 | 0.8342 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0189 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.007 | 0.169 | 0.1599 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0189 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.0109 | 0.0109 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 995 nM | Inhibition of human liver recombinant FBPase | ChEMBL. | 20045638 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.