Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ectonucleotide pyrophosphatase/phosphodiesterase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.2563 | 0.2563 |
Trypanosoma brucei | endonuclease G, putative | 0.0024 | 0 | 0.5 |
Trypanosoma cruzi | endonuclease G, putative | 0.0024 | 0 | 0.5 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0024 | 0 | 0.5 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2563 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0024 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2563 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1553 | 0.6061 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0034 | 0.1553 | 0.6061 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.004 | 0.2563 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2563 | 0.1195 |
Schistosoma mansoni | hypothetical protein | 0.0087 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2563 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2563 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.2563 | 0.2563 |
Echinococcus granulosus | ectonucleotide | 0.0034 | 0.1553 | 0.6061 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2563 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2563 | 1 |
Leishmania major | endonuclease G, putative | 0.0024 | 0 | 0.5 |
Trypanosoma cruzi | endonuclease G, putative | 0.0024 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.2563 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2563 | 0.1195 |
Onchocerca volvulus | 0.0087 | 1 | 1 | |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0087 | 1 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.004 | 0.2563 | 0.2563 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.004 | 0.2563 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.0034 | 0.1553 | 0.6061 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.26 uM | Inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis | ChEMBL. | 20349977 |
Inhibition (binding) | = -5 % | Inhibition of human recombinant C-terminal FLAG-tagged NPP6 expressed in baculovirus-infected Sf9 cells assessed as pNPPC hydrolysis at 10 uM relative to control | ChEMBL. | 20349977 |
Inhibition (binding) | = 9 % | Inhibition of human recombinant C-terminal FLAG-tagged NPP7 expressed in baculovirus-infected Sf9 cells assessed as pNPPC hydrolysis at 10 uM relative to control | ChEMBL. | 20349977 |
Inhibition (binding) | = 17.731 % | Inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis at 30 uM | ChEMBL. | 20349977 |
Inhibition (binding) | = 25.889 % | Inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis at 10 uM | ChEMBL. | 20349977 |
Inhibition (binding) | = 39.616 % | Inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis at 3 uM | ChEMBL. | 20349977 |
Inhibition (binding) | = 60.597 % | Inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis at 1 uM | ChEMBL. | 20349977 |
Inhibition (binding) | = 78.734 % | Inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis at 0.3 uM | ChEMBL. | 20349977 |
Inhibition (binding) | = 80 % | Inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis at 10 uM relative to control | ChEMBL. | 20349977 |
Inhibition (binding) | = 89.403 % | Inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis at 0.1 uM | ChEMBL. | 20349977 |
Inhibition (binding) | = 95.733 % | Inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis at 0.03 uM | ChEMBL. | 20349977 |
Inhibition (binding) | = 97.44 % | Inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis at 0.01 uM | ChEMBL. | 20349977 |
Inhibition (binding) | = 97.866 % | Inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis at 0.003 uM | ChEMBL. | 20349977 |
Ki (binding) | = 1.46 uM | Competitive inhibition of human recombinant C-terminal FLAG-tagged autotaxin expressed in baculovirus-infected Sf9 cells assessed as FS-3 hydrolysis by Michaelis-Menten method | ChEMBL. | 20349977 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.