Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.6709 | 1 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.6709 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.3878 | 0.5455 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.6709 | 1 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.1357 | 0.1409 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.1568 | 0.1747 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.231 | 0.2938 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.3878 | 0.5455 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.1568 | 0.1747 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.1568 | 0.1747 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.3878 | 0.5455 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.1568 | 0.1747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1088 | 0.0977 | 0.5592 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.6709 | 1 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.1568 | 0.1747 | 0.1747 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.1568 | 0.1747 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.1568 | 0.1747 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.6709 | 1 | 0.5 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.1568 | 0.1747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1088 | 0.0977 | 0.5592 |
Leishmania major | DNA topoisomerase ii | 0.1088 | 0.0977 | 0.1791 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.6709 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.1088 | 0.0977 | 0.1791 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.1568 | 0.1747 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.1568 | 0.1747 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.1568 | 0.1747 | 0.1747 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.3878 | 0.5455 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.1568 | 0.1747 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.1568 | 0.1747 | 0.3202 |
Brugia malayi | Probable DNA topoisomerase II | 0.1568 | 0.1747 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.4399 | 0.6292 | 0.6292 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.1088 | 0.0977 | 0.1791 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.1568 | 0.1747 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.1088 | 0.0977 | 0.1791 |
Trypanosoma brucei | DNA topoisomerase ii | 0.3878 | 0.5455 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.1088 | 0.0977 | 0.1791 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.6 nM | Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assay | ChEMBL. | 20138761 |
IC50 (functional) | = 4.9 nM | Antiinflammatory activity against LPS-induced TNFalpha production in human THP1 cells after 3 hrs | ChEMBL. | 20138761 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20138761 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.