Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glutathione S-transferase, putative | 0.042 | 0.035 | 0.5 |
Trichomonas vaginalis | glutaminyl-tRNA synthetase, putative | 0.0324 | 0 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0668 | 0.1252 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3071 | 1 | 1 |
Echinococcus multilocularis | glutathione S-transferase | 0.042 | 0.035 | 0.2797 |
Echinococcus granulosus | glutathione s transferase mu | 0.042 | 0.035 | 0.2797 |
Echinococcus multilocularis | glutathione s transferase mu | 0.042 | 0.035 | 0.2797 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0668 | 0.1252 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0668 | 0.1252 | 1 |
Echinococcus granulosus | prostaglandin H2 D isomerase | 0.042 | 0.035 | 0.2797 |
Echinococcus multilocularis | prostaglandin H2 D isomerase | 0.042 | 0.035 | 0.2797 |
Echinococcus multilocularis | glutathione S transferase | 0.042 | 0.035 | 0.2797 |
Echinococcus multilocularis | glutathione S transferase | 0.042 | 0.035 | 0.2797 |
Onchocerca volvulus | 0.0324 | 0 | 0.5 | |
Echinococcus granulosus | glutathione S transferase | 0.042 | 0.035 | 0.2797 |
Plasmodium falciparum | glutathione S-transferase | 0.042 | 0.035 | 0.5 |
Echinococcus multilocularis | glutathione S transferase | 0.042 | 0.035 | 0.2797 |
Echinococcus granulosus | glutathione S transferase Mu 1 | 0.042 | 0.035 | 0.2797 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 58 uM | Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay | ChEMBL. | 24913712 |
IZ (functional) | = 17 mm | Antifungal activity against fluconazole-resistant Candida albicans at 100 ug/well after 24 hrs by well diffusion assay | ChEMBL. | 24913712 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.