Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | folate hydrolase (prostate-specific membrane antigen) 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | similar to transferrin receptor | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Candida albicans | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Schistosoma japonicum | ko:K01301 glutamate carboxypeptidase II [EC3.4.17.21], putative | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_128101 | All targets in OG5_128101 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3554 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1359 | 0.3632 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0131 | 0.012 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1359 | 0.3632 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3554 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.3554 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3554 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3554 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3554 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1359 | 0.3632 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3554 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.3554 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1359 | 0.3632 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1359 | 0.3632 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0175 | 0.0163 |
Schistosoma mansoni | dihydrofolate reductase | 0.3554 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1359 | 0.3632 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.012 nM | Inhibition of human recombinant N-terminal Avi-tagged glutamate carboxypeptidase 2 extracellular domain (44 to 750 amino acids) using pteroyl-di-L-glutamate substrate by HPLC method | ChEMBL. | 24954515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.