Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MET proto-oncogene, receptor tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | plexin A | 0.0025 | 0.0487 | 0.0487 |
Loa Loa (eye worm) | TK protein kinase | 0.027 | 1 | 1 |
Brugia malayi | plexin A | 0.0025 | 0.0487 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.9841 | 0.9841 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0022 | 0.0376 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0169 | 0.0169 |
Schistosoma mansoni | cell adhesion molecule | 0.0022 | 0.0376 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0022 | 0.0376 | 0.0211 |
Echinococcus granulosus | roundabout 2 | 0.0022 | 0.0376 | 0.0211 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0022 | 0.0376 | 0.005 |
Schistosoma mansoni | plexin | 0.0021 | 0.0338 | 0.8992 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0021 | 0.0328 | 0.0328 |
Echinococcus granulosus | plexin a4 | 0.0025 | 0.0487 | 0.0323 |
Echinococcus granulosus | tyrosine protein kinase | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0169 | 0.0169 |
Onchocerca volvulus | 0.0021 | 0.0338 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0338 | 0.0338 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0169 | 0.0169 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0169 | 0.0169 |
Echinococcus multilocularis | tyrosine protein kinase | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0169 | 0.0169 |
Brugia malayi | Plexin repeat family protein | 0.0021 | 0.0338 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0376 | 0.0376 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0016 | 0.0169 | 0.4492 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0376 | 0.0376 |
Schistosoma mansoni | nephrin | 0.0022 | 0.0376 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0016 | 0.0169 | 0.4492 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0376 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0169 | 0.0169 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0016 | 0.0169 | 0.4492 |
Echinococcus multilocularis | plexin a4 | 0.0025 | 0.0487 | 0.0323 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0376 | 0.0376 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.46 uM | Inhibition of recombinant MET kinase domain (unknown origin) | ChEMBL. | 24951334 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.