Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 26 % | Displacement of [3H]N6-R-phenylisopropyladenosine from human A1AR expressed in CHO cells at 10 uM after 60 mins by scintillation counting analysis | ChEMBL. | 24969016 |
Inhibition (binding) | = 41 % | Displacement of [3H]2-[p-(2-carboxyethyl)phenyl-ethylamino]-5'-N-ethylcarboxamido-adenosine from human A2aAR expressed in HEK293 cells at 10 uM after 60 mins by scintillation counting analysis | ChEMBL. | 24969016 |
Ki (binding) | = 7.31 nM | Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from human A3AR expressed in CHO cells after 60 mins by scintillation counting analysis | ChEMBL. | 24969016 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.