Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | formyl peptide receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | 0.0675 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0254 | 0.3494 | 1 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0254 | 0.3494 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0254 | 0.3494 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0675 | 1 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0028 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0028 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | GnHR receptor homolog | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0254 | 0.3494 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0028 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0254 | 0.3494 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0675 | 1 | 1 |
Brugia malayi | Dopamine receptor protein 1 | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0254 | 0.3494 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0254 | 0.3494 | 1 |
Brugia malayi | G protein-coupled receptor | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0254 | 0.3494 | 1 |
Brugia malayi | neuropeptide F receptor | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0254 | 0.3494 | 1 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | putative neuropeptide receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0254 | 0.3494 | 1 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0254 | 0.3494 | 1 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0028 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0254 | 0.3494 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0254 | 0.3494 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0254 | 0.3494 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0254 | 0.3494 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0254 | 0.3494 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0254 | 0.3494 | 1 |
Brugia malayi | Serotonin receptor | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0254 | 0.3494 | 1 |
Brugia malayi | Dopamine receptor protein 2 | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0254 | 0.3494 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0254 | 0.3494 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0254 | 0.3494 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0254 | 0.3494 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0254 | 0.3494 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.059 | 0.8693 | 0.8693 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0675 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0254 | 0.3494 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | G-protein coupled receptor | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0254 | 0.3494 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0028 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0028 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0254 | 0.3494 | 1 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0254 | 0.3494 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 420 nM | Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method | ChEMBL. | 25035262 |
Inhibition (functional) | Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of MMK1-induced calcium mobilization at 1 to 10 uM incubated for 5 mins prior to MMk1 challenge by Fura-2 method | ChEMBL. | 25035262 | |
Inhibition (functional) | Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method | ChEMBL. | 25035262 | |
Kd (functional) | = 16 nM | Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins prior to fMLP challenge by Fura-2 method | ChEMBL. | 25035262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.