TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 378.421 | Formula: C22H22N2O4
H donors: 1 H acceptors: 1 LogP: 3.51 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)CCN1C2Oc2ccc3c(c2C1)c(C(=O)OC)c([nH]3)C
InChi: 1S/C22H22N2O4/c1-12-19(22(25)27-3)20-16-11-24-9-8-13-10-14(26-2)4-5-15(13)21(24)28-18(16)7-6-17(20)23-12/h4-7,10,21,23H,8-9,11H2,1-3H3
InChiKey: CFROMQQFSYBIHZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholinergic receptor, muscarinic 5	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, muscarinic 3	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, muscarinic 1	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, muscarinic 4	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, muscarinic 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133264	All targets in OG5_133264
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133264	All targets in OG5_133264

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	G-protein coupled receptor	0.0093	0.0089	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1187	0.1187
Brugia malayi	GnHR receptor homolog	0.0093	0.0089	0.0299
Echinococcus granulosus	tm gpcr rhodopsin	0.0093	0.0089	0.0201
Echinococcus granulosus	neuropeptide s receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0312	0.4435	0.4435
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0136	0.094	0.094
Schistosoma mansoni	histamine h1 receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	serotonin receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Brugia malayi	G protein-coupled receptor	0.0093	0.0089	0.0299
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.0239	0.298	0.5
Echinococcus granulosus	somatostatin receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0093	0.0089	0.0089
Loa Loa (eye worm)	neuropeptide F receptor	0.0093	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0093	0.0089	0.0201
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Onchocerca volvulus		0.0136	0.094	1
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0136	0.094	0.3155
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	neuropeptide s receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	neuropeptide F-like receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	growth hormone secretagogue receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	G protein coupled receptor 139	0.0093	0.0089	0.0201
Brugia malayi	Dopamine receptor protein 1	0.0093	0.0089	0.0299
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Loa Loa (eye worm)	G-protein coupled receptor	0.0093	0.0089	0.0089
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0093	0.0089	0.0201
Onchocerca volvulus		0.0136	0.094	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Echinococcus granulosus	dro:myosuppressin receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	hormone sensitive lipase	0.0312	0.4435	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0093	0.0089	0.0299
Schistosoma mansoni	biogenic amine receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	neuropeptide receptor A26	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus granulosus	7tm_1 domain containing protein	0.0093	0.0089	0.0201
Echinococcus multilocularis	neuropeptide Y receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	TYRA-2 protein	0.0093	0.0089	0.0089
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0093	0.0089	0.0201
Brugia malayi	hypothetical protein	0.0093	0.0089	0.0299
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Brugia malayi	RE15519p	0.0093	0.0089	0.0299
Schistosoma mansoni	hypothetical protein	0.0093	0.0089	0.0201
Echinococcus granulosus	neuropeptides capa receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	biogenic amine 5HT receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	orexin receptor type 2	0.0093	0.0089	0.0201
Brugia malayi	Polyprenyl synthetase family protein	0.0239	0.298	1
Plasmodium vivax	geranylgeranyl pyrophosphate synthase	0.0239	0.298	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0093	0.0089	0.0201
Brugia malayi	sulfakinin receptor protein	0.0093	0.0089	0.0299
Echinococcus multilocularis	sex peptide receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0093	0.0089	0.0201
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.0239	0.298	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0089	0.0201
Brugia malayi	hypothetical protein	0.0093	0.0089	0.0299
Echinococcus granulosus	fmrfamide receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	neuropeptides capa receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0093	0.0089	0.0089
Echinococcus granulosus	hypothetical protein	0.0093	0.0089	0.0201
Brugia malayi	Dopamine receptor protein 2	0.0093	0.0089	0.0299
Echinococcus granulosus	neuropeptide Y receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus granulosus	neuropeptide Y receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	allatostatin A receptor	0.0093	0.0089	0.0201
Trypanosoma cruzi	farnesyl pyrophosphate synthase, putative	0.0239	0.298	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0089	0.0201
Echinococcus granulosus	neuropeptide receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	serotonin receptor	0.0093	0.0089	0.0201
Brugia malayi	AKH receptor	0.0093	0.0089	0.0299
Echinococcus multilocularis	g protein coupled receptor	0.0093	0.0089	0.0201
Trypanosoma brucei	farnesyl pyrophosphate synthase	0.0239	0.298	1
Schistosoma mansoni	neuropeptide receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0093	0.0089	0.0201
Echinococcus granulosus	G protein coupled receptor 139	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0136	0.094	0.094
Loa Loa (eye worm)	neuropeptide F receptor	0.0093	0.0089	0.0089
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0093	0.0089	0.0201
Schistosoma mansoni	neuropeptide F-like receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	neuropeptide receptor	0.0093	0.0089	0.0201
Onchocerca volvulus		0.0136	0.094	1
Loa Loa (eye worm)	polyprenyl synthetase	0.0239	0.298	0.298
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	neuropeptide receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0093	0.0089	0.0201
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.0239	0.298	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0093	0.0089	0.0089
Brugia malayi	hypothetical protein	0.0093	0.0089	0.0299
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0089	0.0201
Schistosoma mansoni	amine GPCR	0.0093	0.0089	0.0201
Echinococcus multilocularis	dro:myosuppressin receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	adenoreceptor	0.0093	0.0089	0.0201
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0093	0.0089	0.0201
Schistosoma mansoni	opsin-like receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Schistosoma mansoni	neuropeptide receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	somatostatin receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0089	0.0201
Schistosoma mansoni	hypothetical protein	0.0093	0.0089	0.0201
Plasmodium falciparum	geranylgeranyl pyrophosphate synthase, putative	0.0239	0.298	0.5
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	neuropeptides capa receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Brugia malayi	putative neuropeptide receptor NPR1	0.0093	0.0089	0.0299
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	serotonin receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	biogenic amine receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0089	0.0201
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0093	0.0089	0.0201
Brugia malayi	neuropeptide F receptor	0.0093	0.0089	0.0299
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	tm gpcr rhodopsin	0.0093	0.0089	0.0201
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0093	0.0089	0.0201
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0089	0.0201
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0093	0.0089	0.0201
Brugia malayi	ORL1-like opioid receptor	0.0093	0.0089	0.0299
Echinococcus granulosus	farnesyl pyrophosphate synthase	0.0239	0.298	0.672
Trypanosoma cruzi	UDP-glucoronosyl and UDP-glucosyl transferase, putative	0.0148	0.1187	0.3984
Echinococcus granulosus	tm gpcr rhodopsin	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0093	0.0089	0.0299
Giardia lamblia	Farnesyl diphosphate synthase	0.0239	0.298	0.5
Onchocerca volvulus		0.0136	0.094	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Brugia malayi	hypothetical protein	0.0093	0.0089	0.0299
Schistosoma mansoni	biogenic amine receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	neuropeptide FF receptor 2	0.0093	0.0089	0.0201
Brugia malayi	larval opioid receptor	0.0093	0.0089	0.0299
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0093	0.0089	0.0089
Schistosoma mansoni	hypothetical protein	0.0093	0.0089	0.0201
Brugia malayi	hypothetical protein	0.0093	0.0089	0.0299
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0093	0.0089	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	fmrfamide receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	g protein coupled receptor	0.0093	0.0089	0.0201
Brugia malayi	hypothetical protein	0.0093	0.0089	0.0299
Echinococcus granulosus	hormone sensitive lipase	0.0312	0.4435	1
Schistosoma mansoni	amine GPCR	0.0093	0.0089	0.0201
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0093	0.0089	0.0299
Onchocerca volvulus		0.0136	0.094	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus granulosus	sex peptide receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0093	0.0089	0.0201
Brugia malayi	follicle stimulating hormone receptor	0.0093	0.0089	0.0299
Echinococcus granulosus	biogenic amine 5HT receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Brugia malayi	G-protein coupled receptor	0.0093	0.0089	0.0299
Echinococcus multilocularis	g-protein coupled receptor	0.0093	0.0089	0.0201
Onchocerca volvulus		0.0136	0.094	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	neuropeptide f receptor 76f	0.0093	0.0089	0.0201
Schistosoma mansoni	amine GPCR	0.0093	0.0089	0.0201
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0093	0.0089	0.0089
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Loa Loa (eye worm)	G-protein coupled receptor	0.0093	0.0089	0.0089
Echinococcus granulosus	g-protein coupled receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Schistosoma mansoni	opsin-like receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Mycobacterium tuberculosis	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)	0.0239	0.298	0.5
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0093	0.0089	0.0201
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	g protein coupled receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0093	0.0089	0.0201
Brugia malayi	hypothetical protein	0.0093	0.0089	0.0299
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Entamoeba histolytica	s phingosine-1-phosphate lyase 1, putative	0.0088	0	0.5
Schistosoma mansoni	hypothetical protein	0.0093	0.0089	0.0201
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0093	0.0089	0.0299
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0093	0.0089	0.0201
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0093	0.0089	0.0299
Onchocerca volvulus		0.0136	0.094	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	neuropeptides capa receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	farnesyl pyrophosphate synthase	0.0239	0.298	0.672
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0136	0.094	0.3155
Echinococcus multilocularis	neuropeptide Y receptor	0.0093	0.0089	0.0201
Onchocerca volvulus		0.0136	0.094	1
Brugia malayi	hypothetical protein	0.0093	0.0089	0.0299
Echinococcus multilocularis	neuropeptide receptor A26	0.0093	0.0089	0.0201
Echinococcus granulosus	orexin receptor type 2	0.0093	0.0089	0.0201
Schistosoma mansoni	amine GPCR	0.0093	0.0089	0.0201
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.0239	0.298	0.5
Trichomonas vaginalis	geranylgeranyl diphosphate synthase, putative	0.0239	0.298	0.5
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0136	0.094	0.3155
Brugia malayi	hypothetical protein	0.0093	0.0089	0.0299
Echinococcus granulosus	g protein coupled receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Brugia malayi	neuropeptide F receptor	0.0093	0.0089	0.0299
Brugia malayi	Serotonin receptor	0.0093	0.0089	0.0299
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Brugia malayi	Dopamine receptor	0.0093	0.0089	0.0299
Brugia malayi	putative neuropeptide receptor	0.0093	0.0089	0.0299
Echinococcus multilocularis	fmrfamide receptor	0.0093	0.0089	0.0201
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.0239	0.298	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0093	0.0089	0.0201
Echinococcus granulosus	neuropeptide receptor	0.0093	0.0089	0.0201
Echinococcus granulosus	7TM GPCR rhodopsin	0.0093	0.0089	0.0201
Schistosoma mansoni	amine GPCR	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0093	0.0089	0.0201
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0093	0.0089	0.0089
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	g protein coupled receptor	0.0093	0.0089	0.0201
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0093	0.0089	0.0201
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0593	1	1
Schistosoma mansoni	myosin xvIII	0.0093	0.0089	0.0201
Trypanosoma cruzi	farnesyl pyrophosphate synthase	0.0239	0.298	1
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0312	0.4435	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0093	0.0089	0.0201
Brugia malayi	Melatonin receptor type 1A	0.0093	0.0089	0.0299
Brugia malayi	G protein-coupled receptor F59B2.13	0.0093	0.0089	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Brugia malayi	hypothetical protein	0.0093	0.0089	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus multilocularis	allatostatin A receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	neuropeptide receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	neuropeptide receptor	0.0093	0.0089	0.0201
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0312	0.4435	1
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0312	0.4435	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Echinococcus granulosus	rhodopsin orphan GPCR	0.0093	0.0089	0.0201
Schistosoma mansoni	farnesyl pyrophosphate synthase	0.0239	0.298	0.672
Leishmania major	farnesyl pyrophosphate synthase	0.0239	0.298	1
Echinococcus multilocularis	g protein coupled receptor	0.0093	0.0089	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0089	0.0089
Brugia malayi	Serotonin receptor	0.0093	0.0089	0.0299
Schistosoma mansoni	opsin-like receptor	0.0093	0.0089	0.0201

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 501 nM	Evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]-NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL.	9873472
IC50 (binding)	= 501 nM	Evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]-NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL.	9873472
IC50 (binding)	= 3394 nM	Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]-NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL.	9873472
IC50 (binding)	= 3394 nM	Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]-NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL.	9873472
IC50 (binding)	= 3788 nM	Evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]-NMS binding using membranes in transfected chinese hamster ovarian cell	ChEMBL.	9873472
IC50 (binding)	= 3788 nM	Evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]-NMS binding using membranes in transfected chinese hamster ovarian cell	ChEMBL.	9873472
IC50 (binding)	= 4093 nM	Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]-NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL.	9873472
IC50 (binding)	= 4093 nM	Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]-NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL.	9873472
IC50 (binding)	= 13138 nM	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]-NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL.	9873472
IC50 (binding)	= 13138 nM	Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]-NMS binding using membranes from transfected chinese hamster ovarian cell	ChEMBL.	9873472

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL59939

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 91809