Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | NPC1-like 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | aminopeptidase N | 0.0242 | 0.2363 | 0.2661 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0157 | 0.1243 | 0.4578 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0242 | 0.2363 | 1 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0085 | 0.0297 | 0.0335 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0242 | 0.2363 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0242 | 0.2363 | 0.2129 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0085 | 0.0297 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0242 | 0.2363 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0822 | 1 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0242 | 0.2363 | 0.2129 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0085 | 0.0297 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.058 | 0.6814 | 0.7674 |
Loa Loa (eye worm) | hypothetical protein | 0.0737 | 0.888 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0242 | 0.2363 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.1414 | 0.1151 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0085 | 0.0297 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0822 | 1 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0157 | 0.1243 | 0.4578 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0121 | 0.0767 | 0.2272 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0242 | 0.2363 | 0.2129 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0242 | 0.2363 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0119 | 0.0742 | 0.0459 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0242 | 0.2363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0297 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0297 | 0.0335 |
Onchocerca volvulus | 0.0822 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1243 | 0.14 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0242 | 0.2363 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.0112 | 0.0647 | 0.0361 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0242 | 0.2363 | 0.2129 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0242 | 0.2363 | 1 |
Onchocerca volvulus | 0.0242 | 0.2363 | 0.2129 | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0157 | 0.1243 | 0.0975 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.0742 | 0.0459 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.1414 | 0.1151 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0665 | 0.7934 | 0.8935 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.0742 | 0.0459 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0242 | 0.2363 | 0.2129 |
Toxoplasma gondii | aminopeptidase N protein | 0.0085 | 0.0297 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0742 | 0.0836 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0242 | 0.2363 | 0.2129 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0242 | 0.2363 | 1 |
Brugia malayi | hypothetical protein | 0.0242 | 0.2363 | 0.2129 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0085 | 0.0297 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0242 | 0.2363 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1243 | 0.14 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0242 | 0.2363 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0112 | 0.0647 | 0.0361 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0085 | 0.0297 | 0.0335 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0085 | 0.0297 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0242 | 0.2363 | 0.2129 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0242 | 0.2363 | 0.2129 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0242 | 0.2363 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0242 | 0.2363 | 1 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0085 | 0.0297 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0242 | 0.2363 | 0.2129 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0297 | 0.0335 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0242 | 0.2363 | 1 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0242 | 0.2363 | 0.2129 |
Brugia malayi | Peptidase family M1 containing protein | 0.0242 | 0.2363 | 0.2129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 3.4 uM | Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy | ChEMBL. | 24928400 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.