Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Cathepsin B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Cathepsin B | 335 aa | 326 aa | 34.7 % | |
Onchocerca volvulus | Cathepsin L homolog | Cathepsin B | 335 aa | 316 aa | 25.6 % |
Neospora caninum | hypothetical protein | Cathepsin B | 335 aa | 303 aa | 28.4 % |
Dictyostelium discoideum | cysteine proteinase 3 | Cathepsin B | 335 aa | 275 aa | 28.7 % |
Trypanosoma congolense | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | Cathepsin B | 335 aa | 272 aa | 25.0 % |
Onchocerca volvulus | Cathepsin B-like cysteine proteinase 6 homolog | Cathepsin B | 335 aa | 315 aa | 49.2 % |
Plasmodium knowlesi | knowpain-2 | Cathepsin B | 335 aa | 308 aa | 23.1 % |
Plasmodium berghei | dipeptidyl aminopeptidase 2 | Cathepsin B | 335 aa | 311 aa | 22.5 % |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | Cathepsin B | 335 aa | 288 aa | 26.4 % |
Toxoplasma gondii | preprocathepsin c precursor, putative | Cathepsin B | 335 aa | 272 aa | 24.3 % |
Trypanosoma congolense | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | Cathepsin B | 335 aa | 272 aa | 24.6 % |
Trypanosoma congolense | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | Cathepsin B | 335 aa | 297 aa | 23.6 % |
Plasmodium yoelii | cathepsin c precursor | Cathepsin B | 335 aa | 313 aa | 25.2 % |
Trypanosoma cruzi | cysteine proteinase, putative | Cathepsin B | 335 aa | 276 aa | 26.1 % |
Onchocerca volvulus | Cathepsin B | 335 aa | 275 aa | 24.7 % | |
Dictyostelium discoideum | cysteine proteinase 5 precursor | Cathepsin B | 335 aa | 271 aa | 24.4 % |
Giardia lamblia | Cathepsin L precursor | Cathepsin B | 335 aa | 280 aa | 25.0 % |
Trypanosoma congolense | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | Cathepsin B | 335 aa | 297 aa | 23.6 % |
Schistosoma japonicum | Cathepsin C precursor, putative | Cathepsin B | 335 aa | 289 aa | 28.4 % |
Toxoplasma gondii | cathepsin CPC1 | Cathepsin B | 335 aa | 296 aa | 28.7 % |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | Cathepsin B | 335 aa | 275 aa | 32.7 % |
Schistosoma japonicum | ko:K01275 cathepsin C [EC3.4.14.1], putative | Cathepsin B | 335 aa | 351 aa | 28.5 % |
Plasmodium knowlesi | dipeptidyl aminopeptidase 2, putative | Cathepsin B | 335 aa | 297 aa | 24.6 % |
Trypanosoma congolense | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | Cathepsin B | 335 aa | 271 aa | 25.1 % |
Trypanosoma congolense | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | Cathepsin B | 335 aa | 271 aa | 25.1 % |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | Cathepsin B | 335 aa | 287 aa | 25.1 % |
Plasmodium knowlesi | knowpain-4 | Cathepsin B | 335 aa | 304 aa | 25.3 % |
Trypanosoma congolense | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | Cathepsin B | 335 aa | 271 aa | 24.4 % |
Plasmodium berghei | dipeptidyl aminopeptidase 1, putative | Cathepsin B | 335 aa | 313 aa | 25.6 % |
Cryptosporidium hominis | preprocathepsin c precursor | Cathepsin B | 335 aa | 280 aa | 25.7 % |
Brugia malayi | Cathepsin L-like precursor | Cathepsin B | 335 aa | 312 aa | 25.0 % |
Trypanosoma cruzi | cysteine proteinase, putative | Cathepsin B | 335 aa | 276 aa | 25.7 % |
Dictyostelium discoideum | cathepsin L-like proteinase | Cathepsin B | 335 aa | 322 aa | 26.4 % |
Babesia bovis | cathepsin C precursor, putative | Cathepsin B | 335 aa | 305 aa | 25.9 % |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | Cathepsin B | 335 aa | 286 aa | 26.6 % |
Plasmodium knowlesi | knowpain-3 | Cathepsin B | 335 aa | 301 aa | 22.6 % |
Trypanosoma congolense | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | Cathepsin B | 335 aa | 289 aa | 22.8 % |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | Cathepsin B | 335 aa | 312 aa | 23.7 % |
Trypanosoma congolense | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | Cathepsin B | 335 aa | 270 aa | 25.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0166 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1909 | 0.1909 |
Loa Loa (eye worm) | matrixin family protein | 0.0091 | 0.5283 | 0.5283 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.1909 | 0.1909 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1909 | 0.1909 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.1909 | 0.1909 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0055 | 0.2985 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0007 | 0.00000011673 | 0.00000011673 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0166 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.2985 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0053 | 0.2903 | 0.2903 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.009 | 0.5181 | 0.5181 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0046 | 0.2428 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.2985 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0055 | 0.2985 | 0.2985 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0137 | 0.8181 | 0.8181 |
Echinococcus granulosus | cathepsin b | 0.0166 | 1 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0046 | 0.2428 | 0.2428 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0055 | 0.2985 | 0.5 |
Loa Loa (eye worm) | cathepsin B | 0.0055 | 0.2985 | 0.2985 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0091 | 0.5283 | 0.5283 |
Mycobacterium ulcerans | hydrolase | 0.0046 | 0.2428 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1909 | 0.1909 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2428 | 0.2428 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.2903 | 0.2903 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 1 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0046 | 0.2428 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.1909 | 0.1909 |
Onchocerca volvulus | 0.0053 | 0.2903 | 0.3431 | |
Echinococcus granulosus | cathepsin b | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0038 | 0.1909 | 0.1909 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0055 | 0.2985 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0007 | 0.00000011673 | 0.00000011673 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0137 | 0.8181 | 0.8181 |
Onchocerca volvulus | Matrilysin homolog | 0.0084 | 0.4807 | 1 |
Brugia malayi | Matrixin family protein | 0.0038 | 0.1909 | 0.1909 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0038 | 0.1909 | 0.1909 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0084 | 0.4807 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0007 | 0.00000011673 | 0.00000011673 |
Loa Loa (eye worm) | matrixin family protein | 0.0084 | 0.4807 | 0.4807 |
Toxoplasma gondii | cathepsin B | 0.0055 | 0.2985 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.2985 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 15 uM | Inhibition of bovine spleen cathepsin B using Z-Arg-Arg-AMC as substrate after 30 mins by fluorescence assay | ChEMBL. | 24960234 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.