Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ABL proto-oncogene 1, non-receptor tyrosine kinase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0.0031 | 0.0031 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0008 | 0.0031 | 0.0031 |
Schistosoma mansoni | tyrosine kinase | 0.025 | 0.7475 | 0.7475 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0008 | 0.0031 | 0.0031 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0332 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0008 | 0.0031 | 0.0031 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0154 | 0.4513 | 0.4513 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0008 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | SRC-1 | 0.0008 | 0.0031 | 0.0031 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0254 | 0.7587 | 0.7587 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0332 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0332 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0.0031 | 0.0031 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0008 | 0.0031 | 0.0031 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0332 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0103 | 0.2962 | 0.2962 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0332 | 1 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0008 | 0.0031 | 0.0031 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0008 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.2741 | 0.2741 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0008 | 0.0031 | 0.0031 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0008 | 0.0031 | 0.0031 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0103 | 0.2962 | 0.2962 |
Echinococcus granulosus | c src tyrosine kinase | 0.0008 | 0.0031 | 0.0031 |
Leishmania major | 0.0332 | 1 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0008 | 0.0031 | 0.0031 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0008 | 0.0031 | 0.0031 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0332 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0008 | 0.0031 | 0.0031 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0254 | 0.7587 | 0.7587 |
Brugia malayi | SRC-1 | 0.0008 | 0.0031 | 0.0031 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0332 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0254 | 0.7587 | 0.7587 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0332 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0.0031 | 0.0031 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0.0031 | 0.0031 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of Src kinase (unknown origin) | ChEMBL. | No reference | |
IC50 (binding) | = 136 nM | Inhibition of Abl kinase (unknown origin) | ChEMBL. | No reference |
Inhibition (binding) | = 49 % | Inhibition of Src kinase (unknown origin) at 10 uM | ChEMBL. | No reference |
Inhibition (binding) | = 95 % | Inhibition of Abl kinase (unknown origin) at 10 uM | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.