Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.546 | 0.546 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.0156 | 0.0156 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.546 | 0.546 |
Schistosoma mansoni | loxhd1 | 0.0024 | 0.0156 | 0.0286 |
Schistosoma mansoni | rab6-interacting | 0.0024 | 0.0156 | 0.0286 |
Schistosoma mansoni | rab6-interacting | 0.0024 | 0.0156 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | doublecortin family protein | 0.0024 | 0.0156 | 0.0156 |
Brugia malayi | Doublecortin family protein | 0.0024 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0156 | 0.0156 |
Echinococcus granulosus | tyrosine protein kinase | 0.0244 | 1 | 1 |
Onchocerca volvulus | 0.0024 | 0.0156 | 0.5 | |
Schistosoma mansoni | polycystin 1-related | 0.0024 | 0.0156 | 0.0286 |
Echinococcus multilocularis | tyrosine protein kinase | 0.0244 | 1 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0024 | 0.0156 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0156 | 0.0286 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | TK protein kinase | 0.0244 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0156 | 0.0156 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.3543 | 0.649 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.9873 | 0.9873 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.546 | 1 |
Echinococcus granulosus | RUN | 0.0024 | 0.0156 | 0.0156 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.0156 | 0.0156 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.0156 | 0.0156 |
Echinococcus multilocularis | RUN | 0.0024 | 0.0156 | 0.0156 |
Onchocerca volvulus | 0.0024 | 0.0156 | 0.5 | |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0024 | 0.0156 | 0.0156 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0024 | 0.0156 | 0.0156 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0024 | 0.0156 | 0.5 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.0156 | 0.0156 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 2.1 % | Inhibition of COX1 in human platelets using arachidonic acid as substrate assessed as residual activity at 50 uM preincubated for 15 mins before substrate addition measured after 10 mins | ChEMBL. | 25036790 |
Activity (binding) | = 2.1 % | Inhibition of COX2-mediated PGE2 formation in IL1beta/TNFalpha-stimulated human HeLa cells using arachidonic acid as substrate assessed as residual activity at 50 uM measured after 30 mins by ELISA | ChEMBL. | 25036790 |
Activity (binding) | = 4.2 % | Inhibition of 12-LO-mediated 12-HPETE formation in human platelets using arachidonic acid as substrate assessed as residual activity at 50 uM preincubated for 15 mins before substrate addition measured after 10 mins | ChEMBL. | 25036790 |
Activity (binding) | = 53.7 % | Inhibition of 15-LO1-mediated 15-HPETE formation in human eosinophil using arachidonic acid as substrate assessed as residual activity at 50 uM preincubated for 15 mins before substrate addition measured after 10 mins | ChEMBL. | 25036790 |
IC50 (binding) | = 0.6 uM | Inhibition of partially purified recombinant 5-lipoxygenase (unknown origin) using arachidonic acid as substrate preincubated for 15 mins before substrate addition measured after 10 mins by HPLC analysis | ChEMBL. | 25036790 |
IC50 (binding) | = 3.5 uM | Inhibition of 5-lipoxygenase in human PMNL using arachidonic acid as substrate preincubated for 15 mins before substrate addition measured after 10 mins | ChEMBL. | 25036790 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.