Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Mus musculus | glucokinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase | 465 aa | 473 aa | 29.4 % |
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Plasmodium falciparum | hexokinase | 0.0192 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0192 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0192 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0192 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0192 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0192 | 1 | 0.5 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Plasmodium vivax | hexokinase, putative | 0.0192 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 0.5 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0192 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0192 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0192 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0192 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1468 | 0.1468 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | < 14 microL/min/mg | Intrinsic clearance in human liver microsomes at 1 uM after 30 mins in presence of NADPH | ChEMBL. | 25001129 |
EC50 (binding) | = 1.12 uM | Induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes preincubated for 20 mins followed by glucose challenge measured after 40 mins by Hoechst 33342 staining-based assay | ChEMBL. | 25001129 |
IC50 (binding) | = 0.027 uM | Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein-labeled GK measured after 2 to 4 hrs by AlphaScreen assay | ChEMBL. | 25001129 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.