Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | glucokinase | Starlite/ChEMBL | References |
Homo sapiens | glucokinase (hexokinase 4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hexokinase family protein | glucokinase | 465 aa | 473 aa | 29.4 % |
Brugia malayi | Hexokinase family protein | glucokinase (hexokinase 4) | 465 aa | 470 aa | 30.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hexokinase family protein | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0192 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.0192 | 1 | 0.5 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0192 | 1 | 0.5 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Trypanosoma brucei | hexokinase | 0.0192 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0192 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0192 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0192 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.1468 | 0.1468 |
Leishmania major | hexokinase, putative | 0.0192 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0192 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0192 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0192 | 1 | 0.5 |
Onchocerca volvulus | 0.0192 | 1 | 1 | |
Echinococcus multilocularis | hexokinase | 0.0192 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0192 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0192 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0192 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0192 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0192 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0192 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | < 14 microL/min/mg | Intrinsic clearance in human liver microsomes at 1 uM after 30 mins in presence of NADPH | ChEMBL. | 25001129 |
EC50 (binding) | = 2.75 uM | Induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes preincubated for 20 mins followed by glucose challenge measured after 40 mins by Hoechst 33342 staining-based assay | ChEMBL. | 25001129 |
IC50 (binding) | = 0.048 uM | Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein-labeled GK measured after 2 to 4 hrs by AlphaScreen assay | ChEMBL. | 25001129 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.