Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | proteasome subunit beta type 1, putative | proteasome (prosome, macropain) subunit, beta type, 8 | 272 aa | 251 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0086 | 0.2604 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0086 | 0.2604 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0308 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0086 | 0.2604 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0086 | 0.2604 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0086 | 0.2604 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0086 | 0.2604 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0086 | 0.2604 | 0.1294 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0308 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0086 | 0.2604 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0086 | 0.2604 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0086 | 0.2604 | 0.5 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0086 | 0.2604 | 0.1294 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0086 | 0.2604 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0308 | 1 | 0.5 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0086 | 0.2604 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0308 | 1 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0086 | 0.2604 | 0.1294 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0086 | 0.2604 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0308 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0308 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0086 | 0.2604 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0086 | 0.2604 | 0.1294 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0308 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0086 | 0.2604 | 0.1294 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.1 nM | Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometry | ChEMBL. | 25006746 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.