Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | proteasome subunit beta type 1, putative | proteasome (prosome, macropain) subunit, beta type, 8 | 272 aa | 251 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0086 | 0.2604 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0086 | 0.2604 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0308 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0086 | 0.2604 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0308 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0086 | 0.2604 | 0.1294 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0086 | 0.2604 | 0.1294 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0086 | 0.2604 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0086 | 0.2604 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0308 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0086 | 0.2604 | 0.1294 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0086 | 0.2604 | 0.5 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0086 | 0.2604 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0086 | 0.2604 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0086 | 0.2604 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0086 | 0.2604 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0308 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0086 | 0.2604 | 0.1294 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0086 | 0.2604 | 0.1294 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0086 | 0.2604 | 0.5 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0308 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0086 | 0.2604 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0308 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0086 | 0.2604 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0308 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 244 nM | Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometry | ChEMBL. | 25006746 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.