Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | vivapain-2 | 0.0472 | 0.3112 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0472 | 0.3112 | 0.2355 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0951 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0472 | 0.3112 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0325 | 0.099 | 0.099 |
Echinococcus multilocularis | cathepsin b | 0.0951 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0325 | 0.099 | 0.099 |
Entamoeba histolytica | cysteine protease, putative | 0.0472 | 0.3112 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0472 | 0.3112 | 0.3112 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0472 | 0.3112 | 1 |
Onchocerca volvulus | 0.0472 | 0.3112 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0472 | 0.3112 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0472 | 0.3112 | 0.2355 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0472 | 0.3112 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0472 | 0.3112 | 0.3112 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0472 | 0.3112 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0325 | 0.099 | 0.099 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.3112 | 0.2355 |
Leishmania major | cathepsin L-like protease | 0.0472 | 0.3112 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0472 | 0.3112 | 1 |
Leishmania major | cathepsin L-like protease | 0.0472 | 0.3112 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0472 | 0.3112 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0369 | 0.1627 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Onchocerca volvulus | 0.0472 | 0.3112 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0472 | 0.3112 | 0.3112 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0472 | 0.3112 | 1 |
Leishmania major | cathepsin L-like protease | 0.0472 | 0.3112 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0325 | 0.099 | 0.3182 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0472 | 0.3112 | 0.3112 |
Echinococcus multilocularis | cysteine protease | 0.0472 | 0.3112 | 0.3112 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0325 | 0.099 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0951 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0472 | 0.3112 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0472 | 0.3112 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0951 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0472 | 0.3112 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0472 | 0.3112 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0472 | 0.3112 | 0.3112 |
Brugia malayi | cathepsin L-like precursor | 0.0325 | 0.099 | 0.099 |
Brugia malayi | Cathepsin L-like precursor | 0.0325 | 0.099 | 0.099 |
Brugia malayi | Cathepsin L-like precursor | 0.0472 | 0.3112 | 0.3112 |
Leishmania major | cathepsin L-like protease | 0.0472 | 0.3112 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0472 | 0.3112 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0472 | 0.3112 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0472 | 0.3112 | 0.3112 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0472 | 0.3112 | 0.3112 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0472 | 0.3112 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0369 | 0.1627 | 0.1627 |
Leishmania major | cathepsin L-like protease | 0.0472 | 0.3112 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0369 | 0.1627 | 0.5229 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0472 | 0.3112 | 0.3112 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0472 | 0.3112 | 0.3112 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0472 | 0.3112 | 0.3112 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0472 | 0.3112 | 0.3112 |
Onchocerca volvulus | 0.0472 | 0.3112 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0951 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0472 | 0.3112 | 0.2355 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0472 | 0.3112 | 0.3112 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0369 | 0.1627 | 0.5229 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0472 | 0.3112 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0472 | 0.3112 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0951 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0369 | 0.1627 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0472 | 0.3112 | 0.2355 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0472 | 0.3112 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0472 | 0.3112 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0472 | 0.3112 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0472 | 0.3112 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0472 | 0.3112 | 0.3112 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Echinococcus granulosus | cathepsin b | 0.0951 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0472 | 0.3112 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0472 | 0.3112 | 0.3112 |
Leishmania major | cathepsin L-like protease | 0.0472 | 0.3112 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0951 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0472 | 0.3112 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Onchocerca volvulus | 0.0472 | 0.3112 | 1 | |
Onchocerca volvulus | 0.0472 | 0.3112 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0951 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0325 | 0.099 | 0.3182 |
Plasmodium vivax | vivapain-2 | 0.0472 | 0.3112 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0472 | 0.3112 | 0.3112 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0472 | 0.3112 | 0.3112 |
Echinococcus multilocularis | cysteine protease | 0.0472 | 0.3112 | 0.3112 |
Loa Loa (eye worm) | cathepsin B | 0.0369 | 0.1627 | 0.0707 |
Brugia malayi | Cathepsin L-like precursor | 0.0472 | 0.3112 | 0.3112 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0325 | 0.099 | 0.099 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0369 | 0.1627 | 0.1627 |
Echinococcus granulosus | cathepsin l1 | 0.0472 | 0.3112 | 0.3112 |
Onchocerca volvulus | 0.0472 | 0.3112 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0472 | 0.3112 | 0.3112 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0472 | 0.3112 | 0.2355 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0472 | 0.3112 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0472 | 0.3112 | 0.3112 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0951 | 1 | 1 |
Onchocerca volvulus | 0.0472 | 0.3112 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0325 | 0.099 | 0.099 |
Giardia lamblia | Cathepsin B precursor | 0.0369 | 0.1627 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.