Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0179388 | 0.138327 | 0.138327 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0332261 | 0.400572 | 0.332381 |
Schistosoma mansoni | P2X receptor subunit | 0.0224734 | 0.216115 | 0.216115 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0179388 | 0.138327 | 0.0403035 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0158293 | 0.102141 | 0.102141 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0681692 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0681692 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0332261 | 0.400572 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0127041 | 0.0485295 | 0.5 |
Onchocerca volvulus | 0.0158293 | 0.102141 | 0.5 | |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0681692 | 1 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0179388 | 0.138327 | 0.121257 |
Schistosoma mansoni | dihydrofolate reductase | 0.0332261 | 0.400572 | 0.400572 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0681692 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0224734 | 0.216115 | 0.216115 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0332261 | 0.400572 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0681692 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0127041 | 0.0485295 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0332261 | 0.400572 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0332261 | 0.400572 | 0.332381 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0332261 | 0.400572 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0127041 | 0.0485295 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0127041 | 0.0485295 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0681692 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0681692 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0681692 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0127041 | 0.0485295 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0179388 | 0.138327 | 0.0403035 |
Brugia malayi | Dihydrofolate reductase | 0.0332261 | 0.400572 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0332261 | 0.400572 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0127041 | 0.0485295 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0332261 | 0.400572 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 39.7 uM | Cytotoxicity against human THP1 cells infected with intracellular amastigote stage of Leishmania donovani MHOM/ET/67/HU3 | ChEMBL. | 25036797 |
EC50 (functional) | = 2.1 uM | Antitrypanosomal activity against intracellular Trypanosoma cruzi infected in human U2OS cells after 48 hrs by confocal microscopy | ChEMBL. | 25036797 |
EC50 (functional) | = 5.29 uM | Antileishmanial activity against intracellular amastigote stage of Leishmania donovani MHOM/ET/67/HU3 infected in human THP1 cells after 3 days by confocal microscopy | ChEMBL. | 25036797 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania donovani | ChEMBL23 | 25036797 | |
Trypanosoma cruzi | ChEMBL23 | 25036797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.